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Inactivation of promoter 1B of APC causes partial gene silencing: evidence for a significant role of the promoter in regulation and causative of familial adenomatous polyposis

Familial adenomatous polyposis (FAP) is caused by germline mutations in the adenomatous polyposis coli (APC) gene. Two promoters, 1A and 1B, have been recognized in APC, and 1B is thought to have a minor role in the regulation of the gene. We have identified a novel deletion encompassing half of this promoter in the largest family (Family 1) of the Swedish Polyposis Registry. The mutation leads to

Chronic widespread pain is associated with slower cognitive processing speed in middle-aged and older European men

Evidence from clinic-based studies suggests that the fibromyalgia syndrome (FMS) is associated with impairment in cognitive function though the mechanism is unclear. The aim of this analysis was to determine whether there is a similar association between chronic widespread pain (CWP), a cardinal feature of FMS, and impaired cognition in a community setting. Men (n = 3369, 40-79 years) were recruit

Relaxation effects in MRI-based quantification of fat content and fatty acid composition.

Purpose: To investigate various sources of bias in MRI-based quantification of fat fraction (FF) and fatty acid composition (FAC) using chemical shift-encoded techniques. Methods: Signals from various FFs and FACs and individual relaxation rates of all signal components were simulated. From these signals, FF and FAC parameters were estimated with and without correction for differences in individua

Classification of Eating Disturbance in Children and Adolescents: Proposed Changes for the DSM-V

Childhood and adolescence are critical periods of neural development and physical growth. The malnutrition and related medical complications resulting from eating disorders such as anorexia nervosa (AN), bulimia nervosa (BN) and eating disorder not otherwise specified may have more severe and potentially more protracted consequences during youth than during other age periods. The consensus opinion

Manufacturer brands versus private brands: Hoch's strategic framework and the Swedish food retail sector

The purpose of this study was to contribute to the knowledge of how manufacturer brands choose and can choose to defend themselves vis-à-vis introduction of private brands by retailers. The study adopts the same research approach as a Dutch empirical study (Verhoef, P. C., E. J. Nijssen, and L. M. Sloot. 2002. “Strategic Reactions of National Brand Manufacturers Towards Private Labels – An Empiric

Method for High Accuracy Multiplicity Correlation Measurements

A novel method for measuring particle multiplicity correlations is presented. The method takes reduced acceptance and detection efficiency into account, in a purely statistical manner. The method does therefore not require any information from simulations - only knowledge of the detectors capability. The method provides the ability to measure forward-backward particle multiplicity correlations wit

Magnetic properties of MnSb inclusions formed in GaSb matrix directly during molecular beam epitaxial growth

Despite of intensive search for the proper semiconductor base materials for spintronic devices working at room temperature no appropriate material based on ferromagnetic semiconductors has been found so far. We demonstrate that the phase segregated system with MnSb hexagonal inclusions inside the GaSb matrix, formed directly during the molecular beam epitaxial growth reveals the ferromagnetic prop

The carbon budget of the northern cryosphere region

The northern cryosphere is undergoing substantial warming of permafrost and loss of sea ice. Release of stored carbon to the atmosphere in response to this change has the potential to affect the global climate system. Studies indicate that the northern cryosphere has been not only a substantial sink for atmospheric CO2 in recent decades, but also an important source of CH4 because of emissions fro

The oxygen dimer in Si: Its relationship to the light-induced degradation of Si solar cells?

It is widely believed that the light induced degradation of crystalline silicon solar cells is due to the formation of a BsO2i recombination center created by the optically excited migration of the oxygen dimer (charge-state-driven motion). In this letter the concentration dependence of the neutral state of O-2i on [O-i] in p- and n-type Cz-Si has been determined using infrared absorption. A syste

Charged kaon femtoscopic correlations in pp collisions at root s=7 TeV

Correlations of two charged identical kaons (KchKch) are measured in pp collisions at root s = 7 TeV by the ALICE experiment at the Large Hadron Collider (LHC). One-dimensional (KKch)-K-ch correlation functions are constructed in three multiplicity and four transverse momentum ranges. The (KKch)-K-ch femtoscopic source parameters R and lambda are extracted. The (KKch)-K-ch correlations show a slig

The impact of catch-and-release on the foraging behaviour of pike (Esox lucius) when released alone or into groups

A commonly practiced method intended to reduce mortality from recreational fisheries is mandatory (e.g., small fish protected by minimum-size limits) or voluntary catch-and-release (C&R), where fish are caught with hook and line and released alive on the assumption that fish survive unharmed. C&R can, however, have both lethal and sub-lethal consequences for fish, with altered behaviour se

Accelerating crystal plasticity simulations using GPU multiprocessors

Crystal plasticity models are often used to model the deformation behavior of polycrystalline materials. One major drawback with such models is that they are computationally very demanding. Adopting the common Taylor assumption requires calculation of the response of several hundreds of individual grains to obtain the stress in a single integration point in the overlying FEM structure. However, a

Smoking and the risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition

Background: Smoking is not associated with prostate cancer incidence in most studies, but associations between smoking and fatal prostate cancer have been reported. Methods: During 1992 and 2000, lifestyle information was assessed via questionnaires and personal interview in a cohort of 145112 European men. Until 2009, 4623 incident cases of prostate cancer were identified, including 1517 cases of

Increased risk of cirrhosis and hepatocellular cancer during long-term follow-up of patients with biopsy-proven NAFLD.

Abstract Objective. Our aims were to investigate the natural history of biopsy-proven non-alcoholic fatty liver disease (NAFLD) in Sweden, its associated complications, the clinical and biochemical factors associated with more advanced liver disease and the survival rate with a mean follow-up time of 27 years. Material and methods. All subjects participating in the population-based prospective coh

Catalytically Active Silica Nanoparticle-Based Supramolecular Architectures of Two Proteins - Cellobiose Dehydrogenase and Cytochrome c on Electrodes

Artificial nanobiomolecular architectures that follow natural examples in protein assembly become more and more important from basic and applied points of view. Our study describes the investigation on cellobiose dehydrogenase (CDH), cytochrome c (cyt c), and silica nanoparticles (SiNP's) for the construction of fully catalytically active supramolecular architectures on electrodes. We report on in