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The effect of amyloid associated proteins on the expression of genes involved in amyloid-beta clearance by adult human astrocytes

Astrocytes appear to be important mediators in the clearance of amyloid beta1-42 (A beta), the key component of senile plaques characteristic of Alzheimer's disease (AD). Recently, we found the amyloid associated proteins (AAPs) alpha 1-antichymotrypsin (ACT), apolipoprotein J and E (ApoJ and ApoE) and a mixture of serum amyloid P (SAP) and C1q (SAP-C1q) to modify A beta-uptake by human astrocytes

Update on the management of pancreatic cancer: Surgery is not enough.

Pancreatic ductal adenocarcinoma (PDAC) represents the fourth cause of death in cancer and has a 5-year survival of < 5%. Only about 15% of the patients present with a resectable PDAC with potential to undergo "curative" surgery. After surgery, local and systemic recurrence, is though very common. The median survival of resected patients with adjuvant chemotherapy after surgery is only 20-23 mo. T

Dynamical self-stabilization of the Mott insulator: Time evolution of the density and entanglement entropy of out-of-equilibrium cold fermion gases

The time evolution of the out-of-equilibrium Mott insulator is investigated numerically through calculations of space-time-resolved density and entropy profiles resulting from the release of a gas of ultracold fermionic atoms from an optical trap. For adiabatic, moderate and sudden switching-off of the trapping potential, the out-of-equilibrium dynamics of the Mott insulator is found to differ pro

Oral and faecal lactobacilli and their expression of mannose-specific adhesins in individuals with and without IgA deficiency

Lactobacilli are present in the intestine and oral cavity of most adults. Secretory IgA in mucosal secretions may provide carbohydrate receptors for bacterial adhesins. Here, oral and faecal samples from 33 IgA-deficient individuals and 34 controls were cultured for lactobacilli, which were identified using species-specific PCR or partial 165 rDNA sequencing and tested for expression of mannose-sp

Palaeogeographic, climatic and tectonic change in southeastern Australia: the Late Neogene evolution of the Murray Basin

The Murray Basin is a low-lying but extensive intracratonic depocentre in southeastern Australia, preserving an extraordinary record of Late Neogene sedimentation. New stratigraphic and sedimento-logic data allow the long-term evolution of the basin to be re-evaluated and suggest a significant role for: (1) tectonism in controlling basin evolution, and (2) progressive and step-wise climatic change

Nano-plastics in the aquatic environment.

The amount of plastics released to the environment in modern days has increased substantially since the development of modern plastics in the early 1900s. As a result, concerns have been raised by the public about the impact of plastics on nature and on, specifically, aquatic wildlife. Lately, much attention has been paid to macro- and micro-sized plastics and their impact on aquatic organisms. Ho

Cystatin C properties crucial for uptake and inhibition of intracellular target enzymes.

To elucidate the molecular requirements for cancer cell internalization of the extracellular cysteine protease inhibitor cystatin C, 12 variants of the protein were produced and used for uptake experiments in MCF-7 cells. Variants with alterations in the cysteine cathepsin binding region ((Δ1-10)-, K5A-, R8G-, (R8G,L9G,V10G)-, (R8G,L9G,V10G, W106G)-, and W106G-cystatin C) were internalized to a ve

Transverse thermal stresses in concrete box cross-sections due to climatic exposure

Spatial and temporal temperature variations in a concrete structure due to variations in the surrounding climate will produce movements which, if restrained, may induce stresses in the structure. To get a better understanding of transverse thermal stresses due to climatic effects in concrete box cross-sections, the FE simulations in this study have been performed using extensive climatic input dat

The Cambrian–Ordovician transition in dysoxic facies in Baltica— diverse faunas and carbon isotope anomalies

The Cambrian–Ordovician boundary interval in Scandinavia is characterized by largely endemic trilobite species and fossil-meager intervals within the Alum Shale Formation. Previous investigations of this interval in Scandinavia, based on drill cores, are rather sketchy. In order to characterize the faunal signature in a largely dysoxic setting during this time interval, as well as providing biostr

Characterization of the New Serum Protein Reference Material ERM-DA470k/IFCC: Value Assignment by Immunoassay

BACKGROUND: The availability of a suitable matrix reference material is essential for standardization of the immunoassays used to measure serum proteins. The earlier serum protein reference material ERM-DA470 (previously called CRM470), certified in 1993, has led to a high degree of harmonization of the measurement results. A new serum protein material has now been prepared and its suitability in

Phase field modelling of stress corrosion

The evolution of surfaces exposed to an aggressive environment and mechanical load is studied. This is a process of stress corrosion that leads to pitting, crack initiation and growing cracks. In conventional fracture analyses a known or a postulated crack is required. A serious complication is that a large part of the lifetime of a crack or a surface flaw is spent during the initiation of the cra

Acceptance and importance of clinical pharmacists' LIMM-based recommendations.

Objective The objective of this study was to evaluate the quality of the clinical pharmacy service in a Swedish hospital according to the Lund Integrated Medicine Management (LIMM) model, in terms of the acceptance and clinical significance of the recommendations made by clinical pharmacists. Method The clinical significance of the recommendations made by clinical pharmacists was assessed for a ra

Local Unfolding and Aggregation Mechanisms of SOD1: A Monte Carlo Exploration.

Copper, zinc superoxide dismutase 1 (SOD1) is a ubiquitous homodimeric enzyme, whose misfolding and aggregation play a potentially key role in the neurodegenerative disease amyotrophic lateral sclerosis (ALS). SOD1 aggregation is thought to be preceded by dimer dissociation and metal loss, but the mechanisms by which the metal-free monomer aggregates remain incompletely understood. Here we use imp

Addition of infliximab compared with addition of sulfasalazine and hydroxychloroquine to methotrexate in early rheumatoid arthritis: 2-year quality-of-life results of the randomised, controlled, SWEFOT trial.

OBJECTIVE: To compare EuroQol 5-Dimensions (EQ-5D) utility and quality-adjusted life-years (QALYs) in patients with early, methotrexate (MTX) refractory rheumatoid arthritis (RA), randomised to addition of infliximab (IFX) or sulfasalazine and hydroxychloroquine (SSZ+HCQ). METHODS: RA-patients with symptoms 3.2 were randomised to addition of IFX or SSZ+HCQ and followed for 21 months. EQ-5D profile

Societal costs of hearing disorders: A systematic and critical review of literature.

Objective: The objective of this study was to perform a critical and systematic literature review of studies on societal costs due to hearing disorders. Design: We used predefined search terms and inclusion/exclusion criteria. Systematic searches were conducted in Medline, Cochrane Library, Google Scholar, and other relevant websites. The review included studies written in English or Swedish b