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Controlling inventories in omni/multi-channel distribution systems with variable customer order-sizes

The fast growth of e-commerce and omni/multi-channel retailing brings new challenges for efficient inventory management. One such challenge concerns service differentiation across channels when upstream central warehouses satisfy both direct customer demand and replenishment orders from downstream retailers. Motivated by industry collaboration, we address this issue by developing a combined stock

Planar laser-induced imaging of CH3 for high resolution single-shot reaction-zone visualization in premixed methane/air flames over broad stoichiometric ratios

We report a novel approach for single-shot planar imaging of CH3 radicals in premixed methane and air flames. A 213 nm beam from the 5th harmonic of an Nd:YAG laser was resonantly absorbed by the CH3 radicals, which were excited to the highly pre-dissociative upper level and dissociated to H2 and CH (X), as the main dissociation channel. The CH radicals were consequently excited by a 388 nm beam f

Lack of autoantibodies against collagen and related proteins in collagenous colitis

INTRODUCTION: Collagenous colitis (CC) is a common cause of chronic diarrhea and is characterized by a subepithelial thickened collagen layer in the colonic mucosa. It shares many of the characteristics found in autoimmune diseases, but no autoantibodies have been identified. In CC, an imbalance in collagen turnover is evident. The purpose of the present study was to investigate whether any collag

Investigating out-of-plane strength & stiffness of a nailed glulam connection

During March 2020 a large-span arena, Tarfalahallen, collapsed. The main load-bearing girders with a 54 m span were high and slender glulam trussed beams, supported from below by a cable system via vertical struts. Investigations concluded that the failure was initiated by out-of-plane buckling of the struts and slender beam, in spite of lateral stabilization by steel roof sheeting at the top edge

Assessing the accuracy of [18F]PSMA-1007 PET/CT for primary staging of lymph node metastases in intermediate- and high-risk prostate cancer patients

Background: [18F]PSMA-1007 is a promising tracer for integrated positron emission tomography and computed tomography (PET/CT). Objective: Our aim was to assess the diagnostic accuracy of [18F]PSMA-1007 PET/CT for primary staging of lymph node metastasis before robotic-assisted laparoscopy (RALP) with extended lymph node dissection (ePLND). Design, Setting and Participants: The study was a retrospe

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Public and private policies typically consider the construction of infrastructure the most appropriate response to the problems of water scarcity and water disputes. However, infrastructure in itself not always is the solution. In this context we have the following questions: What are the logics behind the construction and implementation of water infrastructure? Why water infrastructures are not a

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The phenomena of landgrabbing and monopolizing of water sources have gained increasing attention in recent years. Nevertheless, very few studies have dealt with the problem of the grabbing and concentration of resources from an ethnographic perspective that would make it possible to illustrate the different ways in which dispossession takes place, as well as its concrete mechanisms and effects in

A Review of Progress and Applications in Wood Quality Modelling

Purpose of Review: Producing wood of the right quality is an important part of forest management. In the same way that forest growth models are valuable decision support tools for producing desired yields, models that predict wood quality in standing trees should assist forest managers to make quality-influenced decisions. A challenge for wood quality (WQ) models is to predict the properties of po

Leading the Pathway : How Unicamp Is Implementing Sustainable Practices in the Energy Sector in Its Campuses?

Universities are powerful drivers to create and advance knowledge on sustainable development. Furthermore, they can be used as a controlled environment to apply innovative technologies and approaches. This process also embraces industry and government, in the triple helix innovation model, as in the University of Campinas (Unicamp), Brazil—one of the best Latin American universities (3rd)—and imme

Bone Turnover Marker Profiling and Fracture Risk in Older Women : Fracture Risk from Age 75 to 90

Purpose: A major challenge in osteoporosis is to identify individuals at high fracture risk. We investigated six bone turnover markers (BTMs) to determine association with specific fracture types; the time-frame for risk prediction and whether these are influenced by age at assessment. Methods: Population-based OPRA cohort (n = 1044) was assessed at ages 75, 80, 85 and fractures documented for up

Obesogenic Diets Cause Alterations on Proteins and Theirs Post-Translational Modifications in Mouse Brains

Obesity constitutes a major global health threat and is associated with a variety of diseases ranging from metabolic and cardiovascular disease, cancer to neurodegeneration. The hallmarks of neurodegeneration include oxidative stress, proteasome impairment, mitochondrial dysfunction and accumulation of abnormal protein aggregates as well as metabolic alterations. As an example, in post-mortem brai

Performance of αSynuclein RT-QuIC in relation to neuropathological staging of Lewy body disease

Currently, there is a need for diagnostic markers in Lewy body disorders (LBD). α-synuclein (αSyn) RT-QuIC has emerged as a promising assay to detect misfolded αSyn in clinically or neuropathologically established patients with various synucleinopathies. In this study, αSyn RT-QuIC was used to analyze lumbar CSF in a clinical cohort from the Swedish BioFINDER study and postmortem ventricular CSF i

Interventions in Adults With Repaired Coarctation of the Aorta

BACKGROUND: Coarctation of the aorta coexists with other cardiac anomalies and has long-term complications, including recoarctation, which may require intervention after the primary coarctation repair. This study aims to clarify the prevalence of and risk factors for interventions related to the coarctation complex as well as late mortality in a large contemporary patient population. METHODS AND R

Tree migration in the dynamic, global vegetation model LPJ-GM 1.1 : efficient uncertainty assessment and improved dispersal kernels of European trees

The prediction of species geographic redistribution under climate change (i.e. range shifts) has been addressed by both experimental and modelling approaches and can be used to inform efficient policy measures on the functioning and services of future ecosystems. Dynamic global vegetation models (DGVMs) are considered state-of-the art tools to understand and quantify the spatio-temporal dynamics o

The underlying mechanisms of sports injuries in Paralympic Goalball – a mixed-method study

Objective Data from the Paralympic Games indicate a fluctuating injury incidence in the Paralympic sport Goalball, but the mechanisms behind have not been explored. The aims of this study were to; i) quantitatively analyze Goalball injuries reported in the London 2012 and Rio 2016 Paralympic Games, ii) qualitatively explain the differences between both Games, and iii) qualitatively assess general

Finite element model of mechanical imaging of the breast

Purpose: Malignant breast lesions can be distinguished from benign lesions by their mechanical properties. This has been utilized for mechanical imaging in which the stress distribution over the breast is measured. Mechanical imaging has shown the ability to identify benign or normal cases and to reduce the number of false positives from mammography screening. Our aim was to develop a model of mec

The validity and reliability of the Swedish version of the Satisfaction with appearance scale for individuals with systemic sclerosis

Background: Systemic sclerosis (SSc) can lead to visible changes in appearance which could generate concerns among patients. Thus, valid questionnaires that capture these concerns are valuable to identify and communicate appearance concerns. Objective: To determine aspects of the validity and reliability of the Swedish version of the Satisfaction with Appearance scale for individuals with SSc (SWA

Risk of non-fatal suicide attempt in individuals with substance use disorder : the roles of aggregate genetic liability and environmental exposures in a Swedish population-based cohort

Background and Aims: Substance use disorder (SUD) is related to widespread adverse consequences, including higher suicidality. Shared genetic liability has been demonstrated between SUD and suicidality. Here, we measured the factors that contribute to increased risk of non-fatal suicide attempt among individuals with SUD by focusing upon aggregate genetic risks and both childhood and past-year env