Convection-enhanced delivery as a means to deliver therapeutic drugs directly to the brain has shown limited clinical efficacy, primarily attributed to the phenomena of backflow, in which the infused fluid flows preferentially along theshaft catheter rather than forward into the tissue. We have previously developed a finite element model of backflow that includes both material and geometric nonlin

During the late 19th and the early 20th century there was an unprecedented development in medical research. Tissue and cell culture rapidly developed into areas with many contributing scientists. The same is true for tissue transplantation. When these achievements are described afterwards in a historical context and a mainline development is constructed, there are researchers whose pioneering work

This paper seeks to determine the decision-making route relating to hedonic and environmental motivation in green innovation adoption and to show how two similar green innovations can motivate consumers differently. It also aims to determine the effect of domain-specific innovativeness (DSI) on emotions and green identity on environmental motivations. The paper focuses on two types of green transp

An environmentally friendly and inexpensive silica source, sodium silicate solution, was applied to synthesize a free-standing mesoporous silica film at the air/liquid interface, exploiting the co-assembly of cetyltrimethylammonium bromide and polyethylenimine. The effect of the composition of the solution used for the film formation on the mesostructure of the as-synthesized silica films, charact

Background Bothgenetic and lifestyle factors contribute to the risk of type 2 diabetes, but the extent to which there is a synergistic effect of the 2 factors is unclear. The aim of this study was to examine the joint associations of genetic risk and diet quality with incident type 2 diabetes. Methods and findings We analyzed data from 35,759 men and women in the United States participating in the

Quantum phases can be classified by topological invariants, which take on discrete values capturing global information about the quantum state1–13. Over the past decades, these invariants have come to play a central role in describing matter, providing the foundation for understanding superfluids5, magnets6,7, the quantum Hall effect3,8, topological insulators9,10, Weyl semimetals11–13 and other p

Aim: To examine adherence, performance, and safety of self-administered aerobic endurance exercise when exercise intensity was prescribed and self-monitored with the Borg RPE scale in patients with chronic kidney disease (CKD), and the relationship between performed exercise and change in walking distance. Materials and Methods: 97 men and 50 women (age 66 ± 14 years, measured GFR 22 ± 8 mL/min/1.

The formation of sustainable entrepreneurial ecosystems to foster sustainable entrepreneurship in regional and national levels has become an increasing phenomenon. Therefore, the research stream of sustainable entrepreneurial ecosystems is gaining relevance in the sustainable entrepreneurship literature. What has been missing, however, is an empirical analysis of stakeholder collaborations in sust

Ammonia (NH3) is a promising carbon-free energy carrier. Co-firing of ammonia in solid fuel-fired facilities is a feasible solution to reduce carbon dioxide (CO2) emissions. Solid fuels, such as coal and biomass, contain various trace elements, such as alkali metals and sulfur, which are released to the gas phase during combustion. Experimental characterization and modeling are used to study the p

Syftet med det här kapitlet är att belysa grundläggande villkor för organiseringen av diakonala insatser i Svenska kyrkans församlingar. Vi kommer i första hand fokusera på sådana villkor som rör verksamheten i sig men teologiska förutsättningar berörs också. Vi kommer att konstatera att det i stort saknas riktlinjer för organiseringen av församlingarnas diakoni. Arbetets organisering skiljer sig

This paper considers the unfolding of Smart Specialisation Strategy (RIS3) in one of Europe’s innovation-leading metropolitan regions: Stockholm, Sweden. Theoretically, it contributes to debates around change agency and reflects more broadly, which implications arise for metropolitan innovation-leader regions and which are of more generic nature. It argues that actor endowments, dense networks, ex

The health limit values for PM10 concentration which are presently in force cannot be met on many heavily polluted streets in German conurbations. Soot filters, bans on motorised traffic during certain time periods and areas or for specific vehicle classes, speed limits and other measures are meant to lead to a substantial reduction of the pollution. This article compares the effects of the mentio

Accurate maps of past land cover and human land use are necessary for studying the impact of anthropogenic land-cover changes, such as deforestation, on the climate. The maps of past land cover should ideally be separated into naturally occurring vegetation and human-induced changes, thereby enabling the quantification of the effect of human land use on the past climate. We developed a Bayesian hi