Statement of Purpose: Lung cancer is the leading cause of cancer-related deaths and efficient therapies remain elusive. One emerging approach is to use nanoparticles (NPs) that are designed to specifically target malignant cells (1). Such targeting increases on-site drug doses and reduces systemic side effects. A common target in lung tumors is epidermal growth factor receptor (EGFR). Here, we ex

Evacuation times can be shortened in fire scenarios if people choose appropriate routes. Way-finding systems can be used to aid this process, thus their effectiveness needs to be evaluated. In the present study, the way-finding evacuation systems of the Future Circular Collider (FCC) of the European Organization for Nuclear Research (CERN) are investigated as its evacuation design presents several

This article is situated in the context of an intensified discourse within which academic developers are being asked to provide evidence of impact, and argues that theoretical models currently used are imprecise and fail to capture the variation in outcomes from professional development activities. Through reference to previous research on how teachers' thinking can be described in relation to var

Pedestrian dynamics is concerned with understanding the movement patterns that arise in places where more than one person walks. Relating theoretical models to data is a crucial goal of research in this field. Statistical model fitting and model selection are a suitable approach to this problem and here we review the concepts and literature related to this methodology in the context of pedestrian

This paper provides an overview of Subtask B: Tools and methods for solar design, of IEA SHC Task 41: Solar energy and architecture, 2009-2012. The focus of this Subtask was on identifying obstacles that architects are facing when implementing passive and active solar strategies in their design, especially during the early design phase (EDP) of building projects. The results of this Subtask also a

The impact of seven shading devices on daylight quality in a south-oriented office was investigated by simulations with Radiance at three specific times on three sunny days. Daylight quality was assessed for a large number of desk positions by considering simple performance indicators: the absolute and relative work plane illuminance and the absolute and relative luminance of surfaces. The results

BACKGROUND: Patients with a high ventricular rate during atrial fibrillation (AF) are at increased risk of receiving inappropriate implantable cardioverter defibrillator shocks. The objective was to demonstrate the feasibility of high frequency atrioventricular-nodal stimulation (AVNS) to reduce the ventricular rate during AF to prevent inappropriate implantable cardioverter defibrillator shocks.M

Males of both juveniles and adults had significantly longer wings than females, the difference between the sexes being c5.5%. Using wing length as the only criterion, between 97.4% and 88.6% of juveniles and between 98.0% and 93.4% of adults can be unambiguously sexed during autumn/winter. Individuals measured during their second or later autumn/winter had significantly longer wings than those mea

This paper argues that the concept of whistleblowing could best be understood as part of a larger regime of disclosure that includes personal revelations, truth-telling, leaking, informing, snitching and whistleblowing. Disclosure regimes are about knowledge that escapes. This paper discusses the conditions for this escaped knowledge and some of the consequences for organizations and communities.

It is a common belief that embedded expanding inclusions are subjected to an internal homogeneous compressive hydrostatic stress. Still, cracks that appear in precipitates that occupy a larger volume than the original material, are frequently observed. The appearance of cracks has since long been regarded as a paradox. In the present study it is shown that matrix materials that increases its volum

The fracture behaviour of ferritic/ferritic martensitic steels in Ductile to Brittle Transition (DBT) region is well captured by Master Curve approach, except in the upper region of transition due to ductile tearing prior to cleavage. The fracture toughness behavior in the upper region of DBT is generally censored by Master Curve. In this work the Master Curve approach is modified to extend its a

The assessment of fracture behaviour of ferritic/ferritic martensitic steels in Ductile to Brittle Transition (DBT) region iscrucial for shallower cracks. In this work the fracture behavior of In-RAFM steels isinvestigated with systematically varying a/W using Master Curve approach. This a/W effect is investigated using σ∗-V∗approach by calculating the active volume at simulated crack front. It i