Background: Severe eosinophilic asthma is a high-burden disease. Mepolizumab has been effective in several randomized clinical trials. However, such success might not be applicable to patients treated in usual clinical practice. The objectives of this article are to evaluate the efficacy of mepolizumab in severe uncontrolled eosinophilic asthma under usual clinical practice, and to determine chara

Conservation organizations are increasingly applying adaptive capacity assessments in response to escalating climate change impacts. These assessments are essential to identify climate risks to ecosystems, prioritize management interventions, maximize the effectiveness of conservation actions, and ensure conservation resources are allocated appropriately. Despite an extensive literature on the top

We have learnt several lessons from the Nordic countries. The management of natural resources can explain a notable part of their success, but it would be naive to extract from the chapters in this book a recipe laying out a path to success for countries with abundant natural resources.

Climate change will have a progressively increasing impact on environmental degradation and environmentally dependent socio-economic systems with potential to cause substantial population displacement. The key concerns in Less Developed Countries (LDCs) will include serious threats to food security and health, considerable economic decline, inundation of coastal areas, and degradation of land and

Addictive disorders are characterized by cognitive, behavioral, and neurological impairments caused by dysregulations of brain structure that can extend well beyond early withdrawal in the months and years of recovery. The present study aimed to examine the efficacy of neurofeedback rehabilitation on anxiety in methamphetamine abusers. The sample consisted of 14 male methamphetamine drug addicts w

Recurrent pregnancy loss (RPL), defined as three or more consecutive miscarriages, is hypothesized to share some of the same pathogenic factors as placenta-associated disorders. It has been hypothesized that a defect implantation causes pregnancy loss, while a partially impaired implantation may lead to late pregnancy complications. The aim of this retrospective register-based cohort study was to

In the 1930s and 1940s, Ukraine experienced political violence on an unprecedented scale. Political violence by the Soviet government and the German occupation authorities resulted in the death of millions, through starvation, deportations, and massacres, and left wounds which still have not fully healed. Independently of the Soviets and Nazis, mass political violence was carried out also by the O

Introduction: Decline in physical function varies substantially across older individuals due to several extrinsic modifiable factors such as dietary patterns, physical activity and social support. We aimed to determine the association of these factors and their interaction with mobility and muscle strength decline. Methods: We analyzed data from 1686 functionally healthy individuals aged 60 + from

The impact of age and 24-h ambulatory blood pressure (ABPM) on arterial stiffness and carotid intima-media thickness (cIMT) in ischemic stroke patients younger than 60 years of age is poorly explored. A total of 385 acute ischemic stroke patients (aged 49.6±9.7 years, 68% men) were prospectively included and grouped in younger (15–44 years, n = 93) and middle-aged (45–60 years, n = 292). Arterial

We report the observation of photoluminescence emission from airborne gold, silver, and copper nanoparticles. A continuous wave 532 nm laser was employed for excitation. Photoluminescence from gold nanoparticles carried in a nitrogen gas flow was both spectrally resolved and directly imaged in situ using an intensified charge-coupled device camera. The simultaneously detected Raman signal from the

The possibility of suddenly ionized molecules undergoing extremely fast electron hole (or hole) dynamics prior to significant structural change was first recognized more than 20 years ago and termed charge migration. The accurate probing of ultrafast electron hole dynamics requires measurements that have both sufficient temporal resolution and can detect the localization of a specific hole within

Dragonflies are highly skilled and successful aerial predators that are even capable of selectively attending to one target within a swarm. Detection and tracking of prey is likely to be driven by small target motion detector (STMD) neurons identified from several insect groups. Prior work has shown that dragonfly STMD responses are facilitated by targets moving on a continuous path, enhancing the

Obstructive sleep apnea (OSA) is common in patients with coronary artery disease (CAD), in which inflammatory activity has a crucial role. The manifestation of OSA varies significantly between individuals in clinical cohorts; not all adults with OSA demonstrate the same set of symp-toms; i.e., excessive daytime sleepiness (EDS) and/or increased levels of inflammatory biomarkers. The further explor