Background: Aβ42/Aβ40 ratios in cerebrospinal fluid (CSF) and blood are reduced in preclinical Alzheimer’s disease (AD), but their temporal and correlative relationship with cerebral Aβ pathology at this early disease stage is not well understood. In the present study, we aim to investigate such relationships using App knock-in mouse models of preclinical AD. Methods: CSF, serum, and brain tissue

Gunnar Broberg, professor emeritus i idé- och lärdomshistoria vid Lunds universitet, gick ur tiden lördagen den 30 april 2022 i en ålder av 79 år.

Sweden has an ambitious plan to fully decarbonise district heating by 2030 and to contribute with negative emissions of greenhouse gases in 2050. The vagaries of the energy market associated with climate, political, and social changes entail cross-sectoral integration that can fulfill these national targets. Fifth-generation district heating and cooling (5GDHC) is a relatively new concept of distr

Tungsten is a prime candidate material for use in plasma facing components in nuclear fusion reactors. This would entail weathering extreme conditions, such as high thermal loads and particle bombardment. It is of vital importance to understand how tungsten mechanically responds to these conditions, and how it is impacted by the defects that form. The current communication considers how the mechan

Cambodia in 2022 was at the crossroads of the past and the future. Preparations were under way for the imminent power handover to a new generation of Cambodian People’s Party (CPP) leaders, most of whom are scions of the incumbent government. The era of the military fighter generation of CPP leaders led by Prime Minister Hun Sen was drawing to an end, which necessitated the reflection on and the c

Previous research indicates that firms pay a premium to poach workers from exporting firms if experience working for an internationally engaged firm reduces trade costs. Because international experience is less valuable to non-exporters, we would expect to see differences in recruitments between firms that are internationally engaged and those that serve only the domestic market. Moreover, increas

Background: Bioactive adrenomedullin (bio-ADM) is a vasoactive peptide with a key role in reducing vascular hyperpermeability and improving endothelial stability during infection, but it also has vasodilatory properties. Bioactive ADM has not been studied in conjunction with acute respiratory distress syndrome (ARDS), but it has recently been shown to correlate with outcomes after severe COVID-19.

The discovery of ferroelectricity in CMOS-compatible oxides, such as doped hafnium oxide, has opened new possibilities for electronics by reviving the use of ferroelectric implementations on modern technology platforms. This thesis presents the ground-up integration of ferroelectric HfO2 on a thermally sensitive III-V nanowire platform leading to the successful implementation of ferroelectric tran

This paper investigates the use of self-funded commitment contracts to support individuals in achieving their goals of increased physical activity. We compare the effect of soft (non-incentivised) commitment contracts with hard (incentivised) contracts using a randomised experiment with 1629 members of a large gym in Stockholm, Sweden. We find a significant positive impact of being offered a hard

Molecular oxygen is essential for most living species. Consequently, hypoxic or ischemic conditions are major cellular stressors and prominent pathological features in ischemic stroke. Stroke is a global health problem and remains the second leading cause of death or disability worldwide. Current management of the disease focuses on rapid reperfusion by thrombolysis or thrombectomy but these thera

Flank wear VBmax remains one of the most essential and used metrics for measuring tool wear. VBmax is used to characterize tool wear rate, machinability of materials, the quality of machined surface. While VBmax measures the size of wear scar, the shape of the tool wear remains less used but not the least applicable for such characterization. However, quantification of the wear shape requires a mo

OBJECTIVE: To explore how lifestyle and demographic, socioeconomic and disease-related factors are associated with supervised exercise adherence in an osteoarthritis (OA) management programme and their ability to explain exercise adherence.METHODS: A cohort register-based study on participants from the 'Swedish Osteoarthritis Registry' who attended the exercise part of a nationwide Swedish OA mana