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Protocol for extracting and evaluating activity distributions in rat electrocorticograms with principal component analysis and k-nearest neighbor

Principal component analysis (PCA) and k-nearest neighbor (kNN) can be applied to extract and compare activity distributions from electrocorticogram (ECoG) signals across recorded neural activity. Here, we present a protocol for recording ECoG activity from the neocortex of rats and applying PCA and kNN on the recorded data. This protocol allows for comparison between different types of cortical a

Global activity distribution in the cortex: A look on how a global network handles information and perturbations

Studies on cortical function have been a cornerstone in research trying to understand our brains for a long time. For many years now a basic feature of cortical processing has been the idea of a functional localization, with different areas or even neurons in the cortex having clear, individual, functions. This idea has been challenged from the outset, and with new methods to study the cortex the

Nasogastric tube after oesophagectomy and risk of anastomotic leak : a Nordic, multicentre, open-label, randomised, controlled, non-inferiority trial

BACKGROUND: Oesophagectomy, a corner stone in curative treatment of oesophageal cancer, is a complex procedure with high complication rates. Postoperative gastric tube decompression is debated and some centres are abandoning routine nasogastric (NG) tube use. We hypothesised that postoperative NG tube removal is non-inferior to five days of NG tube decompression, with regard to the risk of anastom

Fabrication of Fragment Antibody–Enzyme Complex as a Sensing Element for Immunosensing

Antibody–enzyme complexes (AECs) are ideal molecular recognition elements for im-munosensing applications. One molecule possesses both a binding ability to specific targets and catalytic activity to gain signals, particularly oxidoreductases, which can be integrated into rapid and sensitive electrochemical measurements. The development of AECs using fragment antibodies rather than intact antibodie

Omental preservation versus omentectomy in curative-intent gastrectomy for gastric cancer : Swedish population-based cohort study

BACKGROUND: Omentectomy has traditionally been performed in gastric cancer surgery, but omental preservation has become increasingly common. It is unclear whether omentectomy leads to additional survival benefit compared with omental preservation. This nationwide population-based cohort study aimed to assess survival and surgical outcomes comparing omental preservation to omentectomy in curative-i

Development of tetravalent antibody–enzyme complexes employing a lactate oxidase and the application to electrochemical immunosensors

Antibody–enzyme complexes (AECs) are ideal for immunosensing. Although AECs using antibody fragments can be produced by bacterial hosts, their low affinity limits their sensing applications. We have improved the affinity of AECs by combining two antibodies using Catcher/Tag systems; however, it requires multiple antibodies and an enzyme production process. In this study, to realize the production

Engineered single chain variable fragments (scFvs) with improved pH-dependent kinetics for use in continuous biosensor applications

One challenge in the continuous monitoring of insulin lies with the unavailability of a high-affinity biological recognition element (BRE) with kinetic parameters sufficient to track fluctuating concentrations of insulin in vivo. An approach to overcome this limitation is to engineer a high-affinity BRE to selectively modulate its binding kinetics in response to an external signal. Herein, we desi

Embodied Oscillative Ethics : A Framework for Participatory Ethics in Body Mapping Research

This article presents an innovative participatory approach to the ethical aspects of conducting body mapping research. Drawing from experiences from an earlier project with digital sex workers, we examine how body mapping, when integrated with what we term “embodied oscillative ethics,” creates opportunities for meaningful collaboration and knowledge co-creation while addressing complex ethical ch

Long-term visual outcome and retinal function with and without intravitreal treatments in eyes with central retinal vein occlusion

PurposeTo investigate long-term effects of intravitreal injections on visual outcome, retinal function and structure in eyes with central retinal vein occlusion (CRVO eyes) and macular oedema and compare with untreated CRVO eyes to determine the long-term effects of anti-vascular endothelial growth factor on photoreceptor cell function.MethodsA retrospective study of 38 eyes from 38 CRVO patients.

Narrative of Refugeeness in Sweden : Shifting representations over time

This study examines shifts in Swedish media representations of refugees over three decades by analyzing coverage of refugees from Yugoslavia (1992), Syria (2015), and Ukraine (2022) in the newspaper Dagens Nyheter. Through frame analysis, the research reveals how media narratives reconcile Sweden’s humanitarian self-image with increasingly restrictive refugee policies. While institutional responsi

Shear force capacity of cross laminated timber beams : Numerical investigations of fracture behaviour

This paper deals with numerical investigations of cross laminated timber (CLT) beams. Previous investigations have revealed discrepancies between experimental test results and suggested design methods regarding shear force capacity of such beams. To gain further understanding of the failure behaviour and the shear force capacity, nonlinear finite element analyses have been performed, using a cohes

To Practice What You Preach : Sweden's Feminist Foreign Policy in Diplomatic Work

Between 2014 and 2022, Sweden introduced a feminist foreign policy (FFP), which entailed a “systematic gender equality perspective throughout foreign policy”. This chapter focuses on how FFP was practiced and implemented by officials at Swedish Embassies around the world. Using a framework of practice theory, implementation theory and feminist institutionalism, the overarching questions guiding th

Corruption in Context : Institutions, Infrastructure and Economic Development

Corruption is one of the most pressing and systemic issues of the 21st century,significantly hindering sustainable socio-economic development acrossnations. It undermines trust in authorities and legal institutions, which inturn diminishes investment activities, restricts entrepreneurial growth, andexacerbates social inequality. Kazakhstan, as a country actively working tomodernize public administ

Assessment of water fluxes under the dual threat of changes in land cover and climate variability in the Brazilian Cerrado biome

Study region: The Brazilian wooded Cerrado biome is a tropical savanna, over 50 % of which has been converted to agricultural land. Study focus: We evaluated changes in water balance variables (surface flux, evaporation, soil-water storage, infiltration, groundwater recharge, and root uptake) due to climate change. The study included (i) calibration and validation of the Hydrus model through obser

Att synliggöra elevers litterära repertoarer och möjliggöra text-till-berättelsekopplingar

Syftet med artikeln är att bidra med ny kunskap om hur en lektionsdesign, som tar utgångspunkt i litterära aspekter, kan möjliggöra utveckling av elevers läsförståelse i åk 4. En learning study med utgångspunkt i de litterära aspekterna: karaktärsbeskrivning, miljöbeskrivning, handling och tema genomfördes i tre klasser i årskurs 4 med 60 elever och tre lärare. Det empiriska materialet består av tThe article aims to provide new knowledge regarding how a teaching design, based on literary concepts, makes possible a deeper development of pupils’ reading comprehension in grade 4. A Learning study focusing on the literary concepts: character, setting, plot and themes was conducted in three classes in year 4 with 60 participating pupils and three participating teachers. The empi-rical material

Migration in the Gulf Cooperation Council Countries : Dynamics, Trends and Challenges

The Gulf Cooperation Council (GCC) countries have experienced significant migration trends in recent decades, with a heavy reliance on foreign labour, particularly from Southern Asia. As of 2024, the GCC hosts 25 million migrants, with Southern Asians constituting a significant proportion. This demographic reality has shaped the region's socio-economic structure, with expatriates dominating the pr

”Lager på lager” : Att möjliggöra och synliggöra kommunikativa, kreativa och narrativa kompetenser

I studien tillämpas en undervisningsdesign som sätter berättelser i olika uttrycksformer i centrum bland elever i lågstadiets årskurs 1. Syftet med studien är att undersöka lärares och elevers upplevelser och erfarenheter av att arbeta med undervisningsdesignen för att bidra med kunskap om hur undervisning med berättelsen i centrum kan möjliggöra och synliggöra elevers kommunikativa, kreativa och In the study, a teaching design that focuses on stories in various forms of expression is applied in the first-grade classroom. The aim of the study is to examine teachers’ and pupils’ experiences of working with this teaching design in order to contribute with knowledge regarding how story-centred teaching can make possible and make visible pupils’ communicative, creative, and narrative competenc

En väv av förståelse : Mellanstadieelevers utsagor om sin fiktionsläsning

Syftet med artikeln är att illustrera vilka litterära iakttagelser några elever i årskurs fyra ger uttryck för när de läser berättelsen ”Draken med de röda ögonen” av Astrid Lindgren (1980) och hur dessa iakttagelser kan bidra med kunskap om vad som kan utgöra utgångspunkt och tas tillvara när en Litteraturundervisning planeras och genomförs på mellanstadiet. Datamaterialet består av nio semi-struThe aim of the article is to illustrate which literary observations nine pupils in year four express when they read the story "The Dragon with the Red Eyes" by Astrid Lindgren (1980), and how these observations can contribute with knowledge regarding what the lessons can be based on, and which aspects can be used when literature education is planned and carried out in middle school. The data mater

Re-creating (hi)stories : Social and cultural empowerment

In response to the challenge to educate democratic citizens and prepare them for life in a global and digital world, a teaching design that focuses on stories that re-claim a place in the literary tradition for groups of people who have been marginalised or silenced in literary classics has been developed and implemented in the upper secondary EFL classroom. The aim of this article is to analyse e