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Context: Continuous experimentation (CE) is used by many companies with internet-facing products to improve their business models and software solutions based on user data. Some companies deliberately adopt a systematic experiment-driven approach to software development while some companies use CE in a more ad-hoc fashion. Objective: The goal of this study is to identify factors for success in CE
Reconstructions of past land use and related land-cover changes at local and regional scales are needed to evaluate the potential long-term impacts of land use on the coastal waters of the Baltic Sea. In this purpose, we selected the Gamleby area at the Swedish Baltic Sea coast for a case study. We use a new, high resolution pollen record from a small lake (Lillsjön) located 3.6 km NNW of the bay
Swelling is the most fundamental property of graphite oxides (GO). Here, a structural study of Brodie graphite oxide (BGO) swelling in a set of long chain 1-alcohols (named C11 to C22 according to the number of carbons) performed using synchrotron radiation X-ray diffraction at elevated temperatures is reported. Even the longest of tested alcohols (C22) is found to intercalate BGO with enormous ex
Background: A growing evidence base supports the use of autologous haematopoietic stem cell transplantation (aHSCT) for treatment of relapsing-remitting multiple sclerosis (RRMS), but it has not yet been integrated into most national clinical guidelines. The objective of this study was to assess efficacy and safety when aHSCT is implemented in routine healthcare. Methods: We assessed 231 patients
Fire has the potential to create significant impacts on the built environment. Managing this impact is sometimes pursued without consideration of the interface between the natural and technological worlds. However, as society has recognized the impacts of technological development on environmental sustainability, the need for sustainable and resilient development has emerged. To facilitate sustain
Background: Respiratory virus infections are main triggers of asthma exacerbations. Tezepelumab, an anti-TSLP mAb, reduces exacerbations in patients with asthma, but the effect of blocking TSLP on host epithelial resistance and tolerance to virus infection is not known. Aim: To examine effects of blocking TSLP in patients with asthma on host resistance (IFNβ, IFNλ, and viral load) and on the airwa
Background and purpose — Antibiotic-loaded bone cement (ALBC) and systemic antibiotic prophylaxis (SAP) have been used to reduce periprosthetic joint infection (PJI) rates. We investigated the use of ALBC and SAP in primary total knee arthroplasty (TKA). Patients and methods — This observational study is based on 2,971,357 primary TKAs reported in 2010–2020 to national/regional joint arthroplasty
An emissions barrier was used in premises with indoor air complaints due to emissions from the buildings in question. The emissions comprised chlorophenols/chloroanisoles and polycyclic aromatic hydrocarbons (PAH) from treated wood, volatile organic compounds (VOC) from PVC flooring and/or the glue used to paste the flooring onto a concrete slab, and radon from radium-containing aerated concrete.
Learning outcomes: This case study covers different concepts related to leadership. It should help students analyze business situations from a leader’s perspective. By the end of this case study, students would be able to understand the role and the characteristics of leadership during a crisis using the 11 dimensions of character framework, map leadership personalities using the HEXACO model to u
Measurements of the production of electrons from heavy-flavour hadron decays in pp collisions at s = 13 TeV at midrapidity with the ALICE detector are presented down to a transverse momentum (p T) of 0.2 GeV/c and up to p T = 35 GeV/c, which is the largest momentum range probed for inclusive electron measurements in ALICE. In p-Pb collisions, the production cross section and the nuclear modificati
A new, more precise measurement of the Λ hyperon lifetime is performed using a large data sample of Pb-Pb collisions at sNN=5.02 TeV with ALICE. The Λ and Λ¯ hyperons are reconstructed at midrapidity using their two-body weak decay channel Λ→p+π- and Λ¯→p¯+π+. The measured value of the Λ lifetime is τΛ=[261.07±0.37(stat.)±0.72(syst.)] ps. The relative difference between the lifetime of Λ and Λ¯, w
Average nucleotide identity analysis, based on whole genome sequences of 115 strains previously identified as Aerococcus urinae, an emerging uropathogen, discriminates at least six unique genomic taxa. The whole genome analysis affords clearer species boundaries over 16S rRNA gene sequencing and traditional phenotypic approaches for the identification and phylogenetic organization of Aerococcus sp
The transverse-momentum (pT) spectra and coalescence parameters B2 of (anti)deuterons are measured in p-p collisions at s=13 TeV for the first time in and out of jets. In this measurement, the direction of the leading particle with the highest pT in the event (pTlead>5 GeV/c) is used as an approximation for the jet axis. The event is consequently divided into three azimuthal regions, and the jet s
The azimuthal (Δ φ) correlation distributions between heavy-flavor decay electrons and associated charged particles are measured in pp and p–Pb collisions at sNN=5.02 TeV. Results are reported for electrons with transverse momentum 4 < pT< 16 GeV / c and pseudorapidity | η| < 0.6 . The associated charged particles are selected with transverse momentum 1 < pT< 7 GeV / c , and relative pseudorapidit
Cocaine and amphetamine-regulated transcript (CART) is expressed in pancreatic islet cells and neuronal elements. We have previously established insulinotropic actions of CART in human and rodent islets. The receptor for CART in the pancreatic beta cells is unidentified. We used RNA sequencing of Cartpt knockdown (KD) INS-1 832/13 cells and identified GPR162 as the most Cartpt-regulated receptor.
Introduction: High convection volumes in hemodiafiltration (HDF) result in improved survival; however, it remains unclear whether it is achievable in all patients. Methods: CONVINCE, a randomized controlled trial, randomized patients with end-stage kidney disease 1:1 to high-dose HDF versus high-flux hemodialysis (HD) continuation. We evaluated the proportion of patients achieving high-dose HDF ta
A search for vector-like leptons in multilepton (two, three, or four-or-more electrons plus muons) final states with zero or more hadronic τ-lepton decays is presented. The search is performed using a dataset corresponding to an integrated luminosity of 139 fb−1 of proton-proton collisions at a centre-of-mass energy of 13 TeV recorded by the ATLAS detector at the LHC. To maximize the separation of
Instrumental variable methods are often used for parameter estimation in the presence of confounding. They can also be applied in stochastic processes. Instrumental variable analysis exploits moment equations to obtain estimators for causal parameters. We show that in stochastic processes one can find such moment equations using an integrated covariance matrix. This provides new instrumental varia
The identification of b-jets, referred to as b-tagging, is an important part of many physics analyses in the ATLAS experiment at the Large Hadron Collider and an accurate calibration of its performance is essential for high-quality physics results. This publication describes the calibration of the light-flavour jet mistagging efficiency in a data sample of proton–proton collision events at s=13 Te
