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Down-regulation of S100C is associated with bladder cancer progression and poor survival

PURPOSE: The goal of this study was to identify proteins down-regulated during bladder cancer progression.EXPERIMENTAL DESIGN: By using comparative proteome analysis and measurement of mRNA, we found a significant down-regulation of S100C, a member of the S100 family of proteins, in T24 (grade 3) as compared with RT4 (grade 1) bladder cancer cell lines. Moreover, quantification of the mRNA level r

Expression of HER3, HER4 and their ligand heregulin-4 is associated with better survival in bladder cancer patients

The epidermal growth factor system has been associated to prognosis in patients with bladder cancer based mainly on the expression of the epidermal growth factor (EGF) receptor 1 (EGFR) and HER2 and their activating ligands. Since limited information exists concerning the expression of other parts of the EGF system, we examined the expression of the receptors HER3 and HER4 and their activating lig

Identification of differentially expressed proteins during human urinary bladder cancer progression

Comparative proteome analysis was performed between RT4 (grade-1) and T24 (grade-3) bladder cancer cell lines, in an attempt to identify differentially expressed proteins during bladder cancer progression. Among those relatively abundant proteins, seven spots changed more than two-fold reproducibly and identified by peptide mass fingerprinting using mass spectrometry and database search. We found

Towards Exploring Toxin-Antitoxin Systems in Geobacillus: A Screen for Type II Toxin-Antitoxin System Families in a Thermophilic Genus

The toxin-antitoxin (TA) systems have been attracting attention due to their role in regulating stress responses in prokaryotes and their biotechnological potential. Much recognition has been given to type II TA system of mesophiles, while thermophiles have received merely limited attention. Here, we are presenting the putative type II TA families encoded on the genomes of four Geobacillus strains

(Re-)shaping regional economies : Regional innovation system dynamics and new industrial path development

This dissertation explores the complexities of regional economic restructuring. It casts a light on how regional environments are ‘reconfigured’ in relation to the transformation of existing regional industries and the development of new ones. More specifically, the aim is to advance our understanding of regional innovation system (RIS) reconfiguration in relation to new regional industrial path d

From Simple to Composite Agency : On Kirk Ludwig’s From Individual to Plural Agency

According to Kirk Ludwig, only primitive actions are actions in a primary and non-derivative sense of the term ‘action’. Ludwig takes this to imply that the notion of collective action is a façon de parler – useful perhaps, but secondary and derivative. I argue that, on the contrary, collective actions are actions in the primary and non-derivative sense. First, this is because some primitive actio

Is There a Need to Integrate Human Thermal Models with Weather Forecasts to Predict Thermal Stress?

More and more people will experience thermal stress in the future as the global temperature is increasing at an alarming rate and the risk for extreme weather events is growing. The increased exposure to extreme weather events poses a challenge for societies around the world. This literature review investigates the feasibility of making advanced human thermal models in connection with meteorologic

The Effect of Canthotomy on Blood Perfusion During the Repair of Lower Eyelid Defects

PURPOSE: Canthotomy is frequently used to mobilize extra tissue when repairing larger lower eyelid defects. The aim of this study was to explore the effect of canthotomy on blood perfusion and oxygen tension.METHODS: Eight pigs underwent a wedge resection of the lower eyelid and canthotomy (with cantholysis involving the lateral palpebral artery). The wedge resection was performed 8, 6, and 4 mm f

Measuring originality in science

Originality has self-evident importance for science, but objectively measuring originality poses a formidable challenge. We conceptualise originality as the degree to which a scientific discovery provides subsequent studies with unique knowledge that is not available from previous studies. Accordingly, we operationalise a new measure of originality for individual scientific papers building on the

Very Integrated Program (VIP): health promotion for patients with alcohol and drug use disorders

Behandling av patienter med alkohol- eller drogberoende är en komplex flerstegsprocess som behandlar både substansberoende och co-morbiditeter. Riskfyllda livsstilar, inklusive tobaksrökning, otillräcklig fysisk aktivitet och ohälsosam kost, som kan förvärra hälsotillståndet och själva beroendebehandlingen, är mycket vanligt bland dessa patienter. Det komplexa hälsofrämjande programmet (Very IntegTreatment of patients with alcohol or drug use disorders is a complex multistage process addressing the substance addiction and co-morbidities. The risky lifestyles, including tobacco smoking, insufficient physical activity and unhealthy diet, which can aggravate health condition as well as addiction treatment itself, are very common among these patients. The complex health promotion (Very Integra

Family history of cancer and subsequent risk of cancer : A large-scale population-based prospective study in Japan

Family history (FH) of cancer is an important factor of increased risk of several cancers. Although the association between FH of cancer and concordant cancer risk has been reported in many previous epidemiological studies, no comprehensive prospective study with adjustment for lifestyle habits has evaluated the association of FH of cancer and concordant cancer risk. We investigated the associatio

Life expectancy and disease burden in the Nordic countries : results from the Global Burden of Diseases, Injuries, and Risk Factors Study 2017

BACKGROUND: The Nordic countries have commonalities in gender equality, economy, welfare, and health care, but differ in culture and lifestyle, which might create country-wise health differences. This study compared life expectancy, disease burden, and risk factors in the Nordic region.METHODS: Life expectancy in years and age-standardised rates of overall, cause-specific, and risk factor-specific

Dealing with accountability in project selection

The purpose of this study is to present a framework to assess how project individuals deal with accountability in project selection. The framework is designed based on project selection and accountability literature and empirical data. Empirical data was collected through semi-structured interviews with project individuals working at organizations operating in information technology and working wi

Lowering blood homocysteine with folic acid based supplements : Meta-analysis of randomised trials

Objective: To determine the size of reduction in homocysteine concentrations produced by dietary supplementation with folic acid and with vitamins B-12 or B-6. Design: Meta-analysis of randomised controlled trials that assessed the effects of folic acid based supplements on blood homocysteine concentration. Multivariate regression analysis was used to determine the effects on homocysteine concentr

Nonconfinement Structure Revealed in Dion–Jacobson Type Quasi-2D Perovskite Expedites Interlayer Charge Transport

Dion–Jacobson (DJ) type 2D perovskites with a single organic cation layer exhibit a narrower distance between two adjacent inorganic layers compared to the corresponding Ruddlesden–Popper perovskites, which facilitates interlayer charge transport. However, the internal crystal structures in 2D DJ perovskites remain elusive. Herein, in a p-xylylenediamine (PDMA)-based DJ perovskite bearing bifuncti