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Custom-made 3D-printed cup-cage implants for complex acetabular revisions : evaluation of pre-planned versus achieved positioning and 1-year migration data in 10 patients

Background and purpose — The use of custom-made 3D-printed titanium implants for the reconstruction of large acetabular defects has been successively introduced in the last decade. In an observational cohort study we evaluated the agreement between preoperatively planned and actually achieved cup-cage position as well as 1-year follow-up migration of the cup-cage component. Patients and methods —

Recognition of maturity-onset diabetes of the young in China

Aims/Introduction: Given that mutations related to maturity-onset diabetes of the young (MODY) are rarely found in Chinese populations, we aim to characterize the mutation spectrum of MODY pedigrees. Materials and Methods: Maturity-onset diabetes of the young candidate gene- or exome-targeted capture sequencing was carried out in 76 probands from unrelated families fulfilling the clinical diagnost

Generalized LDPC Codes with Convolutional Code Constraints

Braided convolutional codes (BCCs) are a class of spatially coupled turbo-like codes that can be described by a (2), (3)-regular compact graph. In this paper, we introduce a family of (d v , d c )-regular GLDPC codes with convolutional code constraints (CC-GLDPC codes), which form an extension of classical BCCs to arbitrary regular graphs. In order to characterize the performance in the waterfall

Who Killed Utopia? : Cult Conspiracy Drama and a Television Imaginary

This article focuses on the production and reception of television drama, specifically the case study of conspiracy thriller Utopia. The empirical research is based on 21 production interviews with the makers of the drama and 56 interviews with audience members and fans of the drama. The concept of the television imaginary is used as an analytical lens for investigating the various ways television

Significance of EGFR/HER2 Expression and PIK3CA Mutations in Giant Cell Tumour of Bone Development

Giant Cell Tumour of Bone (GCTB) is a rare bone tumour. Locally aggressive and recurrent, it might evolve into pulmonary metastases. Our present work is aimed at investigating the involvement of the epidermal growth factor receptor (ErbB) family and its downstream effectors in the development and recurrence of GCTB. For this purpose, we used a cohort of 32 GCTB patients and we evaluated the clinic

Imaging in gynecological disease (18) : clinical and ultrasound characteristics of urinary bladder malignancies

Objective: To describe the clinical and ultrasound characteristics of urinary bladder malignancies diagnosed on transvaginal ultrasound in women presenting with suspected gynecological problems. Methods: This was a multicenter retrospective study of women with a histological diagnosis of urinary bladder malignancy that was suspected on transvaginal ultrasound examination. The cases were collected

Photoresponses in the radiolar eyes of the fan worm Acromegalomma vesiculosum

Fan worms (Annelida: Sabellidae) possess compound eyes and other photoreceptors on their radiolar feeding tentacles. These eyes putatively serve as an alarm system that alerts the worm to encroaching threats, eliciting a rapid defensive retraction into their protective tube. The structure and independent evolutionary derivation of these radiolar eyes make them a fascinating target for exploring th

Crystal Structure of Non-Structural Protein 10 from Severe Acute Respiratory Syndrome Coronavirus-2

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), causing Coronavirus Disease 19 (COVID-19), emerged at the end of 2019 and quickly spread to cause a global pandemic with severe socio-economic consequences. The early sequencing of its RNA genome revealed its high similarity to SARS, likely to have originated from bats. The SARS-CoV-2 non-structural protein 10 (nsp10) displays high sequ

Warming weathers changes the chemical composition of oat hulls

The current threats of climate change are driving attention away from the petrochemical industry towards more sustainable and bio‐based production processes for fuels and speciality chemicals. These processes require suitable low‐cost starting material. One potential material assessed here is the oat hull. Its overall chemical composition has so far not been fully characterized. Furthermore, it is

Durability and design parameters of a Steel/PEEK gear pair

The parameters necessary for the reliable design of PEEK gears were determined. The effect of a steel gear's surface on the polymer gear's wear was investigated. Values for the wear coefficient of a steel/PEEK gear pair in dry and lubricated conditions are proposed. Testing showed that, on average, grease lubrication extends the lifespan of PEEK gears by a factor of 1.23, while the additional trea

The role of beliefs, expectations and values in decision-making favoring climate change adaptation : implications for communications with European forest professionals

Beliefs, expectations and values are often assumed to drive decisions about climate change adaptation. We tested hypotheses based on this assumption using survey responses from 508 European forest professionals in 10 countries. We used the survey results to identify communication needs and the decision strategies at play, and to develop guidelines on adequate communications about climate change adBeliefs, expectations and values are often assumed to drive decisions about climate change adaptation. We tested hypotheses based on this assumption using survey responses from 508 European forest professionals in 10 countries. We used the survey results to identify communication needs and the decision strategies at play, and to develop guidelines on adequate communications about climate change ad

Agile product development process transformation to support advanced one-of-a-kind manufacturing : International Journal of Computer Integrated Manufacturing

ABSTRACT Increased competition in the global market has forced companies to diversify their product ranges to meet the customers? changing needs and adopt product development strategies for mass customization or even one-of-a-kind production, which inevitably requires designing modular products. Product modularity is achieved via platform-based systems, in which various combinations of different m

Deterministic Lateral Displacement : Challenges and Perspectives

The advent of microfluidics in the 1990s promised a revolution in multiple industries from healthcare to chemical processing. Deterministic lateral displacement (DLD) is a continuous-flow microfluidic particle separation method discovered in 2004 that has been applied successfully and widely to the separation of blood cells, yeast, spores, bacteria, viruses, DNA, droplets, and more. Deterministic

Novel Methods for the Quantification of Dipeptidyl Peptidase 3 (DPP3) Concentration and Activity in Human Blood Samples

BACKGROUND: The ubiquitously expressed dipeptidyl peptidase 3 (DPP3) is involved in protein metabolism, blood pressure regulation, and pain modulation. These diverse functions of DPP3 are attributed to the degradation of bioactive peptides like angiotensin II. However, because of limitations in currently available assays for determination of active DPP3 in plasma, the exact physiological function

Insulin secretion : The nitric oxide controversy

Nitric oxide (NO) is a gas that serves as a ubiquitous signaling molecule participating in physiological activities of various organ systems. Nitric oxide is produced in the endocrine pancreas and contributes to synthesis and secretion of insulin. The potential role of NO in insulin secretion is disputable – both stimulatory and inhibitory effects have been reported. Available data indicate that e

The Gospel of Matthew as an Argument

This study indicates valuable contributions of narrative criticism and rhetorical criticism. Together with the traditional historical-critical approach, these methods can help us toward an interpretation that lets us better understand the purpose and the function of the gospel-story. One purpose is for it to function as an argument in favour of the standpoint that Jesus is the Son of God, the MessThis study indicates valuable contributions of narrative criticism and rhetorical criticism. Together with the traditional historical-critical approach, these methods can help us toward an interpretation that lets us better understand the purpose and the function of the gospel-story. One purpose is for it to function as an argument in favour of the standpoint that Jesus is the Son of God, the Mess