Abnormal loading of the knee due to injuries or obesity is thought to contribute to the development of osteoarthritis (OA). Small animal models have been used for studying OA progression mechanisms. However, numerical models to study cartilage responses under dynamic loading in preclinical animal models have not been developed. Here we present a musculoskeletal finite element model of a rat knee j

OBJECTIVE: To combine prospective cohort studies, by including HLA harmonization, and estimate risk of islet autoimmunity and progression to clinical diabetes.RESEARCH DESIGN AND METHODS: For prospective cohorts in Finland, Germany, Sweden, and the U.S., 24,662 children at increased genetic risk for development of islet autoantibodies and type 1 diabetes have been followed. Following harmonization

Erfarenheterna av att arbeta digitalt är nu många och användbara. Pandemin slog hårt, men den har också lett till att digitala barnsjukdomar kunnat utrotas, skriver de två forskarna Claire Hoolohan och Tullia Jack.

This Applied Optics feature issue on laser applications to chemical, security, and environmental analysis (LACSEA) highlights papers presented at the LACSEA 2020 Seventeenth Topical Meeting sponsored by The Optical Society (OSA).

Postural control and vestibular and eye motor function were evaluated in 7 postlingually deaf patients before cochlear implantation as vibration toward the calf muscles or galvanic electrical stimulation of the vestibular nerves perturbed stance. The patients were compared with 21 control subjects. Vibration-induced bodysway was increased in the patients compared to the normals. Galvanic stimulati

The prompt production of the charm baryon Λ+c and the Λ+c/D0 production ratios were measured at midrapidity with the ALICE detector in pp and p-Pb collisions at √sNN=5.02 TeV. These new measurements show a clear decrease of the Λ+c/D0 ratio with increasing transverse momentum (pT) in both collision systems in the range 2

The magnitude and distribution of China's terrestrial carbon sink remain uncertain due to insufficient constraints at large scales, whereby satellite data offer great potential for reducing the uncertainty. Here, we present two carbon sink estimates for China constrained either by satellite CO2 column concentrations (XCO2) within the Global Carbon Assimilation System or by remotely sensed soil moi

Scholars of world politics have recently devoted growing attention to the inner workings of international organizations. While this research strand has considerably enhanced our knowledge on the impact of international bureaucracies on global policy-making, their interplay with transnational actors has not been analyzed in much detail. Against this backdrop, the present article addresses the quest

The new species Begonia markiana is described and illustrated. It is similar to B. cathcartii but can easily be distinguished by a lamina with a dark central spot and a densely pilose upper surface in combination with a short dorsal capsule wing. A phylogenetic analysis based on three chloroplast regions placed the new species together with other continental species in section Platycentrum. Both m

This protocol describes the design and use of CRISPRi-mediated transcriptional silencing in human iPSCs, for loss-of-function studies in brain development research. The protocol avoids single cell selection, thereby eliminating side effects of clonal expansion and sites of viral integration. We also describe a neural progenitor differentiation protocol and discuss the challenges of target-specific

This letter proposes a co-designed millimeter-wave (mm-wave) and sub-6GHz antenna system. The antenna system consists of four 28GHz mm-wave arrays with reconfigurable radiation patterns and two sub-6GHz antennas fed with two corner capacitive coupling elements (CCEs). Each corner CCE is formed by the connected ground planes of two mm-wave arrays in the shared-aperture configuration. The two CCEs a

Sufficiency has long been marginalized in the public and political sustainability discourse. Since attempts to reduce CO2 emissions in the long term have so far fallen short of expectations, sufficiency has recently approached the forefront of scientific and social debates about a »good life«. In addition to a strict reduction target, the sufficiency strategy promises psychological well-being and

Background/Objective: The frequencies of non-susceptibility against common antibiotics among pneumococci vary greatly across the globe. When compared to other European countries antibiotic resistance against penicillin and macrolides has been uncommon in Sweden in recent years. Multidrug resistance (MDR) is, however, of high importance since relevant treatment options are scarce. The purpose of th

Rapporten redogör för en fallstudie om hur tillgänglighetsproblem i flerfamiljshus förorsakade av trappsteg kan lösas på nya och bättre sätt. Fyra hus byggda 1959-1966 valdes ut för att ingå i fallstudien. Tre var typiska för flerfamiljshus i Sverige som saknar hissar. Det fjärde huset hade efterinstallerade hissar. Fallens entrémiljöer utvärderades på en undersökande nivå med tillgänglighetsinven

People (re)act differently when facing the pandemic. Multiple opinions about COVID-19 and related issues prevail, both in personal meetings and in (social) media. This article aims to illuminate different ideal types and handling strategies in early stages of the pandemic. A thematic Braun and Clark, and Weber inspired analysis of qualitative data from an international web-based survey was carried