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Reducing levels of the aggregation-prone Aβ peptide that accumulates in the brain with Alzheimer's disease (AD) has been a major target of experimental therapies. An alternative approach may be to stabilize the physiological conformation of Aβ. To date, the physiological state of Aβ in brain remains unclear, since the available methods used to process brain tissue for determination of Aβ aggregate
A large number of human diseases are caused by chronic tissue injury with fibrosis potentially leading to organ failure. There is a need for more effective anti-fibrotic therapies. Congenital muscular dystrophy type 1A (MDC1A) is a devastating form of muscular dystrophy caused by laminin α2 chaindeficiency. It is characterized with early inflammation and build-up of fibrotic lesions, both in patie
In pristine Sphagnum-dominated peatlands, (di)nitrogen (N2) fixing (diazotrophic) microbial communities associated with Sphagnum mosses contribute substantially to the total nitrogen input, increasing carbon sequestration. The rates of symbiotic nitrogen fixation reported for Sphagnum peatlands, are, however, highly variable, and experimental work on regulating factors that can mechanistically exp
Vad är en kompetensportfölj? En samling arbetsprover som visar upp den egna kompetensen? En elektronisk plattform för dokumentlagring? En övning i reflektion och utveckling? I denna rapport samlas erfarenheter från medarbetare vid Lunds universitet som under perioden 2015–2016 har arbetat med kompetensportföljer – för studenter och lärare. Rapporten redovisar resultat från tre delprojekt: • Utveck
Stroke is the leading cause of disability in developed countries and among the major causes of death worldwide. During a stroke, neurons deprived of their normal metabolic substrates cease to function in seconds and show signs of structural damage after only a few minutes which result in the impairment of sensory and motor function. Loss of function after stroke is due to neuronal death and irreve
Under de senaste åren har en doktorand ockuperat den akademiska ledningscentralen och skisserat ett antal renoveringar med mål att förändra premisserna för arbetet med breddad rekrytering av studenter från studieovana hem. Utgångpunkten för renoveringarna är att rikta blicken mot de villkor och strukturer, som ’de studieovana’ möter och istället för att fokusera på hur ’De’ ska anpassas till ’Oss’Over the past few years a Ph.D. student has occupied the academic command centre and sketched a number of renovations in order to change the university’s ongoing work to broaden the recruitment of students from homes with no study habit. The point of departure of the renovations is to direct attention to the terms and structures that people with backgrounds different than the academic norm are sup
Phase diagrams are useful tools to study the phase equilibria of nanowire materials systems because the growth of nanowires is accompanied by phase formation and phase transition. We have modeled the phase equilibria of the As-Au-Ga ternary system by means of the CALPHAD method. This method is a well-established semi-empirical technique for thermodynamic modeling in which Gibbs energy functions wi
A grating compressor is characterized using the dispersion scan technique and a reference piece of glass. The procedure yields both the spectral phase of the ultrashort pulses and the dispersion of the compressor itself.
The harm that pathogens cause to hosts during infection, termed virulence, varies across species from negligible to a high likelihood of rapid death. Classic theory for the evolution of virulence is based on a trade-off between pathogen growth, transmission and host survival, which predicts that higher within-host growth causes increased transmission and higher virulence. However, using data from
A general scaling formalism for nonlinear light-matter interactions in gases is presented and experimentally verified. The formalism enables to conveniently extrapolate nonlinear phenomena, such as filamentation or high-order harmonic generation, to new laser parameters.
We present the development of an instantaneous multispectral imaging technique exploiting spatially modulated light. Each encoded excitation source produces an image with a predefined position in the Fourier domain, allowing them to be separated computationally.
Purpose: The vast majority of previous studies suggest that there is no relationship between the acceptable noise level (ANL) and pure-tone hearing thresholds reported as the average pure-tone hearing thresholds (pure-tone average). This study aims to explore (a) the relationship between hearing thresholds at individual frequencies and the ANL and (b) a measure of the slope of the audiogram and AN
Designing highly integrated and efficient MIMO antennas for mobile handset is challenging, especially for low frequency bands below 1 GHz. In this work, by analyzing and manipulating the characteristic modes of a mobile handset, we propose a low profile dual-band MIMO antenna with high integration ability. Both antennas cover a bandwidth of 100 MHz at the center frequency of 0.9 GHz. The isolation
Large areas of peatlands have worldwide been drained to facilitate agriculture, which has adverse effects on the environment and the global climate. Agriculture on rewetted peatlands (paludiculture) provides a sustainable alternative to drainage-based agriculture. One form of paludiculture is the cultivation of Sphagnum moss, which can be used as a raw material for horticultural growing media. Und
Inputs of salt spray to the blanket bogs, due to their proximity to the coast and the predominant westerly winds from the Atlantic Ocean. To test this hypothesis we carried out an ecohydrological field study at a large blanket bog in the western part of Connemara, Ireland. We described peat profiles in two transects and sampled pore water from peat at different depths. The water samples were analy
