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Lung Mast Cells Have a High Constitutive Expression of Carboxypeptidase A3 mRNA That Is Independent from Granule-Stored CPA3
The mast cell granule metalloprotease CPA3 is proposed to have important tissue homeostatic functions. However, the basal CPA3 mRNA and protein expression among mast cell populations has remained poorly investigated. Using a novel histology-based methodology that yields quantitative data on mRNA and protein expression at a single-cell level, the present study maps CPA3 mRNA and protein throughout
Carolina Uppenberg, I husbonden bröd och arbete. Kön, makt och kontrakt i det svenska tjänstefolkssystemet 1730-1860 : Gothenburg Studies in Economic History 20 (Göteborg: Avdelningen för ekonomisk historia, 2018). 313 pp.
Recension av avhandlingDissertation review
Critical challenges in implementing sustainable transport policy in Stockholm and Gothenburg
This paper explores the mental-models of Swedish planners in order to understand the extent to which they support the ideals of sustainable transport. Focussing on three critical challenges: forecast-led versus vision-led planning; tackling congestion; and, public acceptability; the findings, drawn from in-depth interviews, demonstrate mostly advanced thinking. However, implementation can be at od
Regulation of HPV16 Early Gene Expression
Human papillomavirus type 16 (HPV16) is the most common high-risk type and isassociated with more than 50% cervical cancer cases as well as a number of headand neck cancer cases. The life cycle of HPV16 is strictly linked to celldifferentiation in the squamous epithelium with expression of the HPV16 earlygenes. The oncoproteins E6 and E7 are essential for preventing apoptosis andinducing prolifera
Methodology for developing reduced reaction mechanisms, and their use in combustion simulations
Combustion, present in a vast majority of energy and material production as well as in transportation, represents a foundation of our modern society. To improve and optimize the applications relying on combustion demand a high level of knowledge, and an ability to simulate the combustion process. To do so three-dimensional Computational Fluid Dynamic (CFD) combustion simulations can be used, whereCombustion, present in a vast majority of energy and material production as well as in transportation, represents a foundation of our modern society. To improve and optimize the applications relying on combustion demand a high level of knowledge, and an ability to simulate the combustion process. To do so three-dimensional Computational Fluid Dynamic (CFD) combustion simulations can be used, where
Investigating agency: methodological and empirical challenges
The promise of connecting agency and structure in studies of regional development is to disentangle causal effects and to better understand to what extent and how individuals, groups of individuals, and organisations can shape regional trajectories. This is not without challenges because agency and structure are deep theoretical constructs, which are not easily translated into empirical research.
Distinct mechanisms of resistance to fulvestrant treatment dictate level of ER independence and selective response to CDK inhibitors in metastatic breast cancer
BACKGROUND: Resistance to endocrine treatment in metastatic breast cancer is a major clinical challenge. Clinical tools to predict both drug resistance and possible treatment combination approaches to overcome it are lacking. This unmet need is mainly due to the heterogeneity underlying both the mechanisms involved in resistance development and breast cancer itself.METHODS: To study the complexity
Uppresaren och Upprätthållaren : om kolonnfigurerna i Lunds domkyrkas krypta
Identification of Extracellular Matrix Proteins Secreted by Human Dermal Fibroblasts Cultured in 3D Electrospun Scaffolds
The appreciation that cell interactions in tissues is dependent on their three dimensional (3D) distribution has stimulated the development of 3D cell culture models. We constructed an artificial 3D tumour by culturing human breast cancer JIMT-1 cells and human dermal fibroblasts (HDFs) in a 3D network of electrospun polycaprolactone fibres. Here, we investigate ECM components produced by the cell
Human epidermal growth factor receptor-3 expression is regulated at transcriptional level in breast cancer settings by junctional adhesion molecule-a via a pathway involving beta-catenin and foxa1
The success of breast cancer therapies targeting the human epidermal growth factor receptor-2 (HER2) is limited by the development of drug resistance by mechanisms including upregulation of HER3. Having reported that HER2 expression and resistance to HER2-targeted therapies can be regulated by Junctional Adhesion Molecule-A (JAM-A), this study investigated if JAM-A regulates HER3 expression. Expre
A Static-99R Validation Study on Individuals With Mental Disorders : 5 to 20 Years of Fixed Follow-Up After Sexual Offenses
‘The Static-99R is one of the most commonly used risk assessment instruments for individuals convicted of sexual offenses. It has been validated for use on many populations, but few studies specifically target and describe individuals with mental disorders. Additionally, research on the discriminative properties (how well the instrument separates recidivists from non-recidivists) of the instrument
A novel mouse monoclonal antibody c42 against c-terminal peptide of alpha-1-antitrypsin
The C-terminal-fragments of alpha1-antitrypsin (AAT) have been identified and their diverse biological roles have been reported in vitro and in vivo. These findings prompted us to develop a monoclonal antibody that specifically recognizes C-36 peptide (corresponding to residues 359–394) resulting from the protease-associated cleavage of AAT. The C-36-targeting mouse mono-clonal Immunoglobulin M (I
Driven quadrature and spin squeezing in a cavity-coupled ensemble of two-level states
The generated magnitude of quadrature squeezing in a cavity-coupled ensemble, which is continuously driven using a coherent off-axis field, is theoretically explored. Using a truncated set of equations of motion derived from a Dicke Hamiltonian, steady-state quadrature squeezing of the cavity field is numerically calculated to approach a limit of -3dB, while frequency-modulated quadrature squeezin
A Local Barycentric Version of the Bak–Sneppen Model
We study the behaviour of an interacting particle system, related to the Bak–Sneppen model and Jante’s law process defined in Kennerberg and Volkov (Adv Appl Probab 50:414–439, 2018). Let N≥ 3 vertices be placed on a circle, such that each vertex has exactly two neighbours. To each vertex assign a real number, called fitness (we use this term, as it is quite standard for Bak–Sneppen models). Now f
Remissyttrande: Promemorian En utvidgad möjlighet för hovrätter att avgöra tvistemål på handlingarna
Modersmålsundervisningens bidrag till interkulturell skolutveckling : Språksynens betydelse och modersmålslärarnas potentialer
Runaway stars masquerading as star formation in galactic outskirts
In the outskirts of nearby spiral galaxies, star formation is observed in extremely low gas surface densities. Star formation in these regions, where the interstellar medium is dominated by diffuse atomic hydrogen, is difficult to explain with classic star formation theories. In this letter, we introduce runaway stars as an explanation for this observation. Runaway stars, produced by collisional d
Generation of the human pluripotent stem-cell-derived astrocyte model with forebrain identity
Astrocytes form functionally and morphologically distinct populations of cells with brain-region-specific properties. Human pluripotent stem cells (hPSCs) offer possibilities to generate astroglia for studies investigating mechanisms governing the emergence of astrocytic diversity. We established a method to generate human astrocytes from hPSCs with forebrain patterning and final specification wit
BCAT1 decreases the sensitivity of cancer cells to cisplatin by regulating mTOR-mediated autophagy via branched-chain amino acid metabolism
Cisplatin is one of the most effective chemotherapy drugs and is widely used in the treatment of cancer, including hepatocellular carcinoma (HCC) and cervical cancer, but its therapeutic benefit is limited by the development of resistance. Our previous studies demonstrated that BCAT1 promoted cell proliferation and decreased cisplatin sensitivity in HCC cells. However, the exact role and mechanism