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Effects of Prostate-Specific Antigen Testing on Familial Prostate Cancer Risk Estimates.

Background Family history is a strong risk factor for prostate cancer. The aim of this study was to investigate whether increased diagnostic activity is related to the incidence of prostate cancer among brothers of men with prostate cancer. Methods Data were from the nationwide population-based Prostate Cancer Database Sweden (PCBaSe Sweden), which includes data from the National Prostate Cancer R

THE EFFECT OF REDUCED BREAST COMPRESSION IN BREAST TOMOSYNTHESIS: HUMAN OBSERVER STUDY USING CLINICAL CASES.

The aim of this study was to investigate whether the compression force used with conventional mammography can be reduced with breast tomosynthesis (BT), without adversely affecting the visualisation of normal and pathological structures. Forty-five women were examined with BT using full (same as for 2D mammography) and half compression force. Both examinations were performed with the same acquisit

Polyamine homoeostasis.

The polyamines are essential for a variety of functions in the mammalian cell. Although their specific effects have not been fully elucidated, it is clear that the cellular polyamines have to be kept within certain levels for normal cell function. Polyamine homoeostasis in mammalian cells is achieved by a complex network of regulatory mechanisms affecting synthesis and degradation, as well as memb

Distance bounds for an ensemble of LDPC convolutional codes

An ensemble of (J, K) -regular low-density parity-check (LDPC) convolutional codes is introduced and existence-type lower bounds on the minimum distance dL, of code segments of finite length L and on the free distance dfree are derived. For sufficiently large constraint lengths v, the distances are shown to grow linearly with v and the ratio dL/v approaches the ratio dfee/v for large L. Moreover,

Metabolism of sphingolipids in the gut and its relation to inflammation and cancer development.

Sphingolipids are abundant in the microvillar membrane of intestinal epithelial cells where they are essential for structural integrity and may act as receptors for toxins, virus and bacteria. Metabolism of dietary and membrane sphingolipids in the intestine generates ceramide, sphingosine, sphingosine-1-phosphate, and ceramide-1-phosphate, via the action of alkaline sphingomyelinase, neutral cera

Chemical sensing with laser spectroscopy

Laser spectroscopic techniques constitute powerful tools for chemical sensing. Atoms and molecules can be identified and quantified by their specific spectral signatures and the strength of the signals. A wide variety of methods for establishing spectroscopic contact with the species exist: absorption, emission, fluorescence, Raman scattering, acousto-optic, and opto-galvanic phenomena can be empl

Biological effects of a disposable, canisterless negative pressure wound therapy system.

Objective: Recent developments of negative pressure wound therapy (NPWT) systems have focused on making pumps smaller, lighter, and more portable. The recently introduced PICO system manages wound fluid through a highly breathable film within the dressing, thereby negating the need for a canister, which allows greater mobility and patient concordance. The aim of this study is to compare the biolog

Development and Application of Single-Ended Picosecond Laser Diagnostics

Popular Abstract in Swedish Föreställ dig ett stort rum med bara en liten fyrkantig, ungefär tio centimeter stor, öppning på en av väggarna. Rummet har fem meter långa väggar och är flera meter högt. Golv, tak och alla andra väggar är helt utan öppningar och är inte genomskinliga. Man misstänker att temperaturen varierar mycket så att det kan vara varmt i en del av rummet och kallt i en annan. DärLight detection and ranging (lidar), a method for nonintrusive, single-ended, and range resolved measurements, has been developed and applied for combustion related diagnostics. Employing picosecond laser pulse durations and detectors providing temporal resolution on the order of picoseconds, lidar has been applied successfully for both quantitative temperature- and species concentration measureme

Some structural properties of convolutional codes over rings

Convolutional codes over rings have been motivated by phase-modulated signals. Some structural properties of the generator matrices of such codes are presented. Successively stronger notions of the invertibility of generator matrices are studied, and a new condition for a convolutional code over a ring to be systematic is given and shown to be equivalent to a condition given by Massey and Mittelho

High risk of azoospermia in men treated for childhood cancer.

Summary Childhood cancer survivors (CCS) have an increased risk of impaired spermatogenesis, but data regarding the disease- and treatment-related risk factors of azoospermia are scarce. Such information is crucial both for counselling CCS and for selecting patients for testicular tissue cryopreservation. The proportion of azoospermic men in CCS was 18% [95% confidence interval (CI): 12-26], speci

Stable Homogeneous Gel for Molecular-Sieving of DNA Fragments in Capillary Electrophoresis

A polyacrylamide gel crosslinked with allyl-b-cyclodextrin can be used repeatedly for several weeks for the separation of DNA fragments, since bubbles are not generated during a run. Allyl-b-cyclodextrin can easily be synthesized in one step from allylglycidylether and b-cyclodextrin. The plate numbers for DNA fragments, up to about 1500 bp, are high: for the 21 separation of pBR322/HaeIII fragmen