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Resilience

Resilience is a concept that is both foundational and, at the same time, relentlessly controversial in sustainability science. It is supposed to both provide a fundamental insight into how complex adaptive systems behave—an insight with substantial normative consequences—and serve as an interdisciplinary bridge linking the disparate worlds of the natural and the social sciences. Yet the concept of

Interdisciplinarity

Sustainability science is fundamentally an interdisciplinary venture, but what does this interdisciplinarity imply in practice? And how can, and should, we think about interdisciplinarity more generally? These are important philosophical and methodological questions for sustainability science, the answers to which remain at least partially out of sight for a variety of reasons. This chapter has th

Knowing how : Estate Management, Practical Knowledge, and Agency among Aristocratic Women in Early Modern Sweden

In the seventeenth Century, Swedish aristocratic women successfully acted as managers of landed estates, mills and iron works, and exerted agency in politics. Making qualified decisions and overseeing complex enterprises, their actions in many ways contradicted the prevailing patriarchal ideology. While explanations for this agency have stressed several intersecting factors, the role of learning a

Outcome of a multi-modal CBT-based treatment program for chronic school refusal

School refusal (SR) can have several negative consequences, but effective treatments are available. When chronic, school absence requires comprehensive treatment. This study evaluates an intervention for SR based on a Cognitive Behavioral Therapy (CBT) model, Hemmasittarprogrammet (HSP). Attendance, anxiety, depression, quality of life, and emotional and behavioral symptoms were measured at pre-tr

Reducing the Complexity of LDPC Decoding Algorithms: An Optimization-Oriented Approach

This paper presents a structured optimization framework for reducing the computational complexity of LDPC decoders. Subject to specified performance constraints and adaptive to environment conditions, the proposed framework leverages the adjustable performance-complexity tradeoffs of the decoder to deliver satisfying performance with minimum computational complexity. More specifically, two constra

Weber’s value spheres, functional differentiation, and Zetterberg’s Many-Splendored Society

Weber's notion of value spheres is famous but underdeveloped as a theory framework. Prominent sociologists have shown that it can be used as a unifying force in functionalist differentiation theory, and as a tool in the analysis of modernity. One of the theorists in this tradition is Hans L. Zetterberg, who throughout his varied career remained attached to the idea of society as composed of six va

OmicLoupe : facilitating biological discovery by interactive exploration of multiple omic datasets and statistical comparisons

Background: Visual exploration of gene product behavior across multiple omic datasets can pinpoint technical limitations in data and reveal biological trends. Still, such exploration is challenging as there is a need for visualizations that are tailored for the purpose. Results: The OmicLoupe software was developed to facilitate visual data exploration and provides more than 15 interactive cross-d

Prevalence of germline pathogenic variants in 22 cancer susceptibility genes in Swedish pediatric cancer patients

Up to 10% of pediatric cancer patients harbor pathogenic germline variants in one or more cancer susceptibility genes. A recent study from the US reported pathogenic variants in 22 out of 60 analyzed autosomal dominant cancer susceptibility genes, implicating 8.5% of pediatric cancer patients. Here we aimed to assess the prevalence of germline pathogenic variants in these 22 genes in a population-

Digitally Assisted Adaptive Non-Linearity Suppression Scheme for RF front ends

This paper presents a robust and low-complexity non-linearity suppression scheme for radio frequency (RF) transceiver building blocks to efficiently mitigate intermodulation distortion. The scheme consists of tunable RF components assisted by an auxiliary path equipped with an adaptive digital signal processing algorithm to provide the tuning control. This proposed concept of digitally-assisted tu

Assessing the quality of water used for vegetable irrigation in Tamale Metropolis, Ghana

This paper assesses water quality that is used for vegetable irrigation in Tamale Metropolis, Ghana. A mixed-method of research design was employed in this study to collect and analyze the data based on survey instruments. The paper found that Escherichia coli (E. coli) that is usually used as an indicator of water contamination and heavy metals exist in all taken water samples. The mean concentra

Impact of COVID-19 in paediatric early-phase cancer clinical trials in Europe : A report from the Innovative Therapies for Children with Cancer (ITCC) consortium

Introduction: Data regarding real-world impact on cancer clinical research during COVID-19 are scarce. We analysed the impact of the COVID-19 pandemic on the conduct of paediatric cancer phase I–II trials in Europe through the experience of the Innovative Therapies for Children with Cancer (ITCC). Methods: A survey was sent to all ITCC-accredited early-phase clinical trial hospitals including ques

A Phase I study of inotuzumab ozogamicin in pediatric relapsed/refractory acute lymphoblastic leukemia (ITCC-059 study)

This Phase I study investigated the recommended Phase II dose (RP2D) of inotuzumab ozogamicin (InO), a CD22-directed antibody-drug conjugate, in pediatric patients with multiple-relapsed/refractory (R/R) CD22-positive acute lymphoblastic leukemia (ALL). Patients (≥1-<18 years) received three InO doses (Days 1, 8, 15) per course. Dose-escalation was based on dose-limiting toxicities (DLT) during Co

A new tool to assess Clinical Diversity In Meta-analyses (CDIM) of interventions

Objective: To develop and validate Clinical Diversity In Meta-analyses (CDIM), a new tool for assessing clinical diversity between trials in meta-analyses of interventions. Study design and setting: The development of CDIM was based on consensus work informed by empirical literature and expertise. We drafted the CDIM tool, refined it, and validated CDIM for interrater scale reliability and agreeme

Synthesis of large-area rhombohedral few-layer graphene by chemical vapor deposition on copper

Rhombohedral-stacked few-layer graphene (FLG) displays peculiar electronic properties that could lead to phenomena such as high-temperature superconductivity and magnetic ordering. To date, experimental studies have been mainly limited by the difficulty in isolating rhombohedral FLG with thickness exceeding 3 layers and device-compatible size. In this work, we demonstrate the synthesis and transfe

On the solar air heater thermal enhancement and flow topology using differently shaped ribs combined with delta-winglet vortex generators

A numerical investigation has been conducted to study the convective heat transfer enhancement and friction loss behaviors for turbulent flow by using arrays of differently shaped ribs combined with delta-winglet vortex generators (DWVGs) pair on the absorber plate of a solar air heater. Four transverse vortex generators arrays, i.e., 90° continuous ribs, 90° truncated ribs, 60° V-shaped continuou