Introduction: Both decreased levels of brain-derived neurotrophic factor (BDNF) and hypothalamic–pituitary–adrenal (HPA) axis dysregulation may be involved in the pathophysiology of suicidal behaviour, as well as cognitive symptoms of depression. Pre-clinical and clinical studies have shown interactions between HPA-axis activity and BDNF, but this has not been studied in a clinical cohort of suici

Micromolar concentrations of the biologically active oestrogen 17beta-oestradiol reduce agonist-induced force in vascular preparations through an unidentified mechanism. The aim of the present study was to investigate the importance of oestrogen receptor beta (ERbeta) for oestrogen-induced vascular relaxation. 17beta-oestradiol was added to aortic rings from ERbeta knock-out (-/-) and wild-type (+

When deploying networked computing-based applications, proper resource management of the server-side resources is essential for maintaining quality of service and cost efficiency. The work presented in this thesis is based on six papers, all investigating problems that relate to resource management of server-based systems. Using a queueing system approach we model the performance of a database sys

Denna avhandling består av fyra delstudier som undersöker hur internetreklam påverkar barns visuella uppmärksamhet. Syftet med studierna var att ta reda på om barn distraherades av internetreklam när de interagerade med webbsidor med hjälp av en vanlig webbläsare. Varje delstudie undersökte hur en specifik uppsättning variabler och faktorer gemensamt bidrog till att predicera hur barnen betraktadeThis dissertation consists of four eye-tracking studies that investigate how salient online advertising and children's level of executive function contributes to their advert distraction. In Study 1, children aged 9 were instructed to surf freely on the internet while all advert material appearing on-screen was registered. The analyses examined how perceptual prominence in each online advert was r

We present a new SAH guided approach to subdividing triangles as the scene is coarsely partitioned into smaller sets of spatiallycoherent triangles. Our triangle split approach is integrated into the partitioning stage of a fast BVH construction algorithm, butmay as well be used as a stand alone pre-split pass. Our algorithm significantly reduces the number of split triangles comparedto previous m

Aims/hypothesis: Genome-wide association studies (GWAS) have identified more than 65 genetic loci associated with risk of type 2 diabetes. However, the contribution of distorted parental transmission of alleles to risk of type 2 diabetes has been mostly unexplored. Our goal was therefore to search for parent-of-origin effects (POE) among type 2 diabetes loci in families. Methods: Families from the

This is the protocol for a review and there is no abstract. The objectives are as follows: To assess whether heparin treatment (both UFH and LMWH) in preterm and term newborn infants with diagnosed thrombosis reduces the rate of mortality and morbidity. The intervention will be compared to placebo or no treatment. In addition, the safety of heparin therapy (both UFH and LMWH) will be assessed for

Background: The study focuses on three questions related to the clinical usefulness of microdialysis in severe brain trauma: (1) How frequently is disturbed cerebral energy metabolism observed in various types of lesions? (2) How often does the biochemical pattern indicate cerebral ischaemia and mitochondrial dysfunction? (3) How do these patterns relate to mortality? Method: The study includes 21

Two different cDNAs, homologous to genes for rotenone-insensitive NADH dehydrogenases of bacteria and yeast, were isolated from potato. The encoded proteins, called NDA and NDB, have calculated molecular masses of 55 and 65kDa, respectively. The N-terminal parts show similarity to mitochondrial targeting peptides and the polypeptides are in vitro imported into potato mitochondria. Import processin

Acinetobacter baumannii is a Gram-negative bacterial pathogen responsible for a range of nosocomial infections. The recent rise and spread of multidrug-resistant A. baumannii clones has fueled a search for alternative therapies, including bacteriophage endolysins with potent antibacterial activities. A common feature of these lysins is the presence of a highly positively charged C-terminal domain

Introduction There is a consensus that factors released by the placenta to maternal circulation, including TNF-α, play a key role in activating the maternal endothelium in pregnancies with preeclampsia (PE). Dual perfusion preserves the structural organization of the placenta to a greater degree than other in vitro systems and has been used by our group and others to examine placental pathophysiol

During locomotion we can use information in the retinal flow field to judge whether we will pass to the left or right of an object in the scene (heading). We can also use information in retinal flow to judge whether an object is moving relative to the scene (flow parsing). Both judgements rely on the brain identifying optic flow (global patterns of retinal motion that are characteristic of self-mo

This paper studies the problem of determining the absolute pose of a perspective camera observing a scene through a known refractive plane, the flat boundary between transparent media with different refractive indices. Efficient minimal solvers are developed for the 2D, known orientation and known rotation axis cases, and near-minimal solvers for the general calibrated and unknown focal length cas

In this study, batch biohydrogen production by co-digestion of raw rice straw and activated sewage sludge was investigated with different inoculum heat treatment, pH, S/X ratio (based on VS) and substrate sizes under mesophilic condition. In order to achieve a high bio-hydrogen yield and methanogens activity inhibition, heat treatment of inoculum was optimized at different exposure times (30, 45 &