A high resolution capillary electrophoresis method is developed for monitoring enzymatic reactions catalyzed by glycosyltransferases. Under inverted electroosmotic flow conditions at pH 2.5, the method quantifies UDP, UDP-Gal, UDP-Glc, and UDP-GlcNAc in the range of 10 to 150 μM. Enzyme activity of α-1,3-galactosyltransferase was determined by monitoring the formation of UDP subproduct formed in t

The spatial patterns of precipitation regarding physiography and atmospheric circulations in the Lake Urmia Basin have been investigated. Daily rainfall time series for the 50 most reliable precipitation stations for the period 1980-2010 were analyzed to detect the regional precipitation pattern. To identify rainfall homogeneous regions, principal component analysis was applied to the precipitatio

This contribution deals with investigations on enhanced Fischer–Burmeister nonlinear complementarity problem (NCP) functions applied to a rate-dependent laminate-based material model for ferroelectrics. The framework is based on the modelling and parametrisation of the material’s microstructure via laminates together with the respective volume fractions. These volume fractions are treated as inter

AIM: To assess the absolute and relative educational inequalities in mortality from hip and non-hip fractures in Skåne region, Sweden.METHODS: We conducted a population-based open cohort study. People aged 30-99 years, resident in the region during 1998-2013 ( n = 999, 148) were followed until death, their 100th birthday, relocation outside Skåne, or the end of 2014. We obtained individual-level d

We typically judge that hasteners are causes of what they hasten, while delayers are not causes of what they delay. These judgements, I suggest, are sensitive to an underlying metaphysical distinction. To see this, we need to pay attention to a relation that I call positive security-dependence, where an event E security-depends positively on an earlier event C just in case E could more easily have

Purpose: To assess mean change in visual acuity (VA) overall and stratified by baseline VA after 1 and 2 years’ treatment with aflibercept in a real-life setting. Methods: This was an observational cohort study using nationwide data from the Swedish Macula Register. Treatment-naïve patient eyes with wet age-related macular degeneration and prescribed aflibercept from January 2013 to December 2014

Glatiramer acetate (GA) is used for the treatment of relapsing-remitting multiple sclerosis (MS) and can suppress experimental autoimmune encephalomyelitis in animals. Effective GA treatment is associated with the induction of anti-inflammatory T(H)2 responses and antigen-specific expansion of CD25(+)/Foxp3(+) Tregs through the modulation of antigen-presenting cells. Here, we show that intravenous

This thesis deals with the development and application of laser-based techniques, for gas phasecharacterization/gas imaging in heterogeneous catalysis. Two techniques are presented: planar laser-induced fluorescence (PLIF) and degenerate four wave mixing (DFWM).This thesis is mainly focused on PLIF for the visualization of CO2 and CO in the vicinity of a catalyst during CO oxidation reaction at se

This paper focuses on the effects of sanctions on Swedish firms' sales across markets, as well as sanctions’ effects on their domestic production. As a case study, the paper uses sanctions imposed on Russia and by Russia in 2014. The results suggest that the total costs of these sanctions due to a drop in sales for Swedish firms amounts to around 1 billion SEK in 2013 prices, which implies a rathe

Compared to class relations, gender relations in high sex ratio contexts are understudied. Drawing on data from a survey conducted in rural southern Shaanxi, China, in 2014–2015, this article aims to assess if the section of the never-married male population who wishes to marry but face difficulties in achieving this goal is more or less gender equal in their attitudes than married men and, if so,

The high variability in the hydrological regime of the Eastern Hydrological Region (EHR) of Northeast Brazil often results in floods and droughts, leading to serious socio-economic issues. Therefore, this work aimed to investigate connections between spatiotemporal hydrological variability of the EHR and large-scale climate phenomena. Multivariate statistical techniques were applied to relate clim

Aims: We tested whether parental alcohol use disorder (AUD) predicted adult offspring's likelihood of marriage and marriage to an AUD-affected spouse; whether effects differed as a function of the sex or number of affected parents; and whether they were robust to confounders. Design: Sex-stratified Cox and logistic regression models. Setting: Sweden. Participants: A total of 1 171 070 individuals

This paper tests the null hypothesis of no horizontal inequity in delivery of health care by use of count data hurdle models and Swedish micro data. It differs from most earlier work in three principal ways: First, the tests are carried out separately for physician and hospital care; second, the tests are carried out separately for the probability of seeking care and the amount of care received (g

In this note the veil of ignorance approach is tested as a basis for empirically determining the shape of the social welfare function for QALYs. An experiment is carried out where the participants choose between different societies that differ with respect to per capita QALYs and the distribution of QALYs. The answers are analyzed using logistic regression analysis, According to the results the re

SPI1 (also known as PU.1) is a dominant but transient regulator in early T-cell precursors and a potent transcriptional controller of developmentally important pro-T-cell genes. Before T-lineage commitment, open chromatin is frequently occupied by PU.1, and many PU.1 sites lose accessibility when PU.1 is later down-regulated. Pioneering activity of PU.1 was tested in this developmentally dynamic c

Purpose Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis, with a 5-year survival of, 10% because of diffuse symptoms leading to late-stage diagnosis. That survival could increase significantly if localized tumors could be detected early. Therefore, we used multiparametric analysis of blood samples to obtain a novel biomarker signature of early-stage PDAC. The signature was derived from

Drug-related problems in the elderly is intended to serve as a source of information and clinical support in geriatric pharmacotherapy for students as well as all health care professionals, e.g. physicians, nurses and pharmacists. Pharmacotherapy is of great importance to all mankind. Drugs are however powerful and must be handled appropriately. This is especially important for elderly patients. D

Only three days after the beginning of the nuclear catastrophe in Fukushima, Japan, on 11 March 2011, the German government ordered 8 of the country's 17 existing nuclear power plants (NPPs) to stop operating within a few days. In summer 2011 the government put forward a law - passed in parliament by a large majority - that calls for a complete nuclear phase-out by the end of 2022. These governmen

Most experimental and numerical investigations of high-pressure homogenizers assume that the valve is fed with a constant flowrate. However, technical homogenizers use piston pumps with either 3 or 5 pistons (production- and pilot-scale machines) or a single piston (laboratory-scale machines). This results in flow pulsation. It is still unknown to what extent this influences valve hydrodynamics. M