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Domain swapping is observed for many proteins with flexible conformations. This phenomenon is often associated with the development of conformational diseases. Importantly, domain swapping has been observed for human cystatin C (HCC), a protein capable of forming amyloid deposits in brain arteries. In this study, the ability of short exposure to high-intensity X-ray radiation to induce domain swap
Ecological compensation is the latest member of a growing family of concepts aimed at reducing degradation of environmental quality. This and other concepts of the family – like ecosystem services, green infrastructure, and nature-based solutions – have been subject to a range of different interpretations and subsequent implementation practices. The result is a complex governance system with uncle
BACKGROUND: Up to a third of prostate cancer patients fail curative treatment strategies such as surgery and radiation therapy in the form of biochemical recurrence (BCR) which can be predictive of poor outcome. Recent clinical trials have shown that men experiencing BCR might benefit from earlier intervention post-radical prostatectomy (RP). Therefore, there is an urgent need to identify earlier
INTRODUCTION: Heterogeneity of segmentation protocols for medial temporal lobe regions and hippocampal subfields on in vivo magnetic resonance imaging hinders the ability to integrate findings across studies. We aim to develop a harmonized protocol based on expert consensus and histological evidence.METHODS: Our international working group, funded by the EU Joint Programme-Neurodegenerative Diseas
OBJECTIVES: The Movember Foundation launched the Global Action Plan Prostate Cancer Active Surveillance (GAP3) initiative to create a global consensus on the selection and monitoring of men with low-risk prostate cancer (PCa) on active surveillance (AS). The aim of this study is to present data on inclusion and follow-up for AS in this unique global AS database.PATIENTS AND METHODS: Between 2014 a
In this study, six approaches were used to characterize hydrological changes in the Čepkeliai wetland complex (southeast Lithuania), namely (i) local water-table measurements (WTM), (ii) testate amoebae analysis, (iii) tree-ring width (TRW) series, (iv) peat stratigraphic data, (v) (hydro-) meteorological data (precipitation and river runoff), and (vi) a diachronic analysis of aerial photographs a
CONTEXT: Androgen deprivation therapy (ADT) is the backbone of treatment for advanced prostate cancer. However, castration-resistant prostate cancer (CRPC) nearly invariably develops through a range of different molecular mechanisms accompanied by progression to a more aggressive phenotype.OBJECTIVE: To understand the key molecular mechanisms leading to CRPC and the functional implications of this
BACKGROUND: Abiraterone acetate, a drug that blocks endogenous androgen synthesis, plus prednisone is indicated for metastatic castration-resistant prostate cancer. We evaluated the clinical benefit of abiraterone acetate plus prednisone with androgen-deprivation therapy in patients with newly diagnosed, metastatic, castration-sensitive prostate cancer.METHODS: In this double-blind, placebo-contro
The injection strategy is commonly manipulated to control the stratification level to simultaneously achieve a low pollutant emission and a high efficiency in internal combustion engines. This paper reports on a joint experimental and numerical study of the emission characteristics and engine performance in a heavy-duty direct-injection compression ignition (DICI) engine operating in the HCCI and
THE DISPLACEMENT rate is given for a mode III crack growing in a steady state under dynamic conditions. The material is assumed to be visco-plastic and high strain rates are considered. A regular perturbation expansion is performed. First-order perturbing strains are, with one exception, square root singular near the crack-tip. For overstress exponents less, or equal to 2, a reasonably large regioTHE DISPLACEMENT rate is given for a mode III crack growing in a steady state under dynamic conditions. The material is assumed to be visco-plastic and high strain rates are considered. A regular perturbation expansion is performed. First-order perturbing strains are, with one exception. square root singular near the crack-tip. For overstress exponents less. or equal to 2, a reasonably large regio
Active surveillance (AS) is broadly described as a management option for men with low-risk prostate cancer, but semantic heterogeneity exists in both the literature and in guidelines. To address this issue, a panel of leading prostate cancer specialists in the field of AS participated in a consensus-forming project using a modified Delphi method to reach international consensus on definitions of t
The fracture process of a laminate is analysed. The laminate is a material used for packaging.It consists of a thin aluminium foil with a polymer coating. In both materials, the fractureprocesses are supposed to be dominantly localized plastic deformation. A Barenblatt regionis supposed to spread ahead of the crack tip. This region is analysed in its cross planeinvoking plane deformation conditionThe conditions for crack arrest at speeds down to below 0.1 of the Rayleigh-wave speed are examined. The elastic energy release rate is assumed to be balanced by the deformation work in a viscoplastic continua and the energy release rate in a fracture process region. Fractographic show that a small fraction of the surface is created through ductile rupture. Even though the fraction represents only
Absence epilepsy (AE) is classified as a genetic generalized epilepsies. WAG/Rij strain of rats are regarded one of the most validated models of absence epilepsy. Studies point out the existence of hyperexcitable focus in somatosensory cortex of these rats, which has been attributed to the deficits in the GABAergic system. In the current study, we studied the changes of calcium binding proteins (C
