In order to study the effect of different intensities of anti-vitamin K treatment on coagulation parameters, 23 patients with venous thromboembolism were given, after the initial treatment period, warfarin at doses giving an International Normalised Ratio of 1.3-2.0 for 4 weeks, and of 1.1-1.3 for another 4 weeks. Blood samples were taken at the end of each of these periods and 4 weeks after the e

The aim of this study was to develop a simple experimental methodology and to develop a mechanistic model to characterize the release mechanism from pellets developing cracks during the release process with special focus on osmotic effects. The release of remoxipride from pellets coated with an ethyl cellulose film was chosen as a case study. Dose release experiments at different bulk osmotic pres

Purpose: Evaluation of the possibilities of reducing the accumulation of radiolabeled streptavidin in radiosensitive organs by extracorporeal affinity adsorption (ECAT). Experimental Design: Rats were injected with biotinylated antibody and subjected to removal of the antibodies from the circulation by ECAT 24 h after injection (avidin column). Animals were then injected with In-111-1,4,7,10-tetra

P element-mediated mutagenesis has been used to disrupt an estimated 25% of genes essential for Drosophila adult viability. Mutation of all genes in the fly genome, however, poses a problem, because P elements show significant hotspots of integration. In addition, advanced screening scenarios often require the use of P element-based tools like the generation of germ-line mosaics using FLP recombin

Simulations of a cumulonimbus cloud observed in the Cirrus Regional Study of Tropical Anvils and Cirrus Layers-Florida Area Cirrus Experiment (CRYSTAL-FACE) with an advanced version of the Explicit Microphysics Model (EMM) are presented. The EMM has size-resolved aerosols and predicts the time evolution of sizes, bulk densities and axial ratios of ice particles. Observations by multiple aircraft i

Both reduction in tidal volume (VT) and alveolar recruitment may be important to limit ventilator-associated lung injury during mechanical ventilation of patients with the acute respiratory distress syndrome (ARDS). The aim of this study was to assess the risk of alveolar derecruitment associated with VT reduction from 10 to 6 ml/kg. Whether this VT-related derecruitment could be reversed, either

Near- and mid-infrared absorption spectra of pure water and aqueous 1.0 g/dL glucose solutions in the wavenumber range 8000-950 cm(-1) were measured in the temperature range 30-42 C in steps of 2 degreesC. Measurements were carried out with an FT-IR spectrometer and a variable pathlength transmission cell controlled within 0.02 degreesC. Pathlengths of 50 mum and 0.4 mm were used in the mid- and n

Optical properties of human whole blood were investigated in vitro at 633 nm using a double integrating sphere set-up, The blood flow was maintained at a constant rate through a flow cell while continuously heating the blood at 0.2-1.1 degrees C/min from approximately 25 to 55 degrees C in a heat exchanger, A small, but rather abrupt decrease in the scattering asymmetry factor (g-factor) of 1.7 +/

The structure of the oxygen-induced p(4x4) reconstruction of Ag(111) is determined by a combination of scanning tunneling microscopy, surface x-ray diffraction, core level spectroscopy, and density functional theory. We demonstrate that all previous models of this surface structure are incorrect and propose a new model which is able to explain all our experimental findings but has no resemblance t

This paper describes a system to create animated 3D scenes of car accidents from written reports. The text-to-scene conversion process consists of two stages. An information extraction module creates a tabular description of the accident and a visual, simulator generates and animates the scene. We outline the overall structure of the text-to-scene conversion and the template structure. We then des

In many studies, particularly in the field of systems biology, it is essential that identical protein sets are precisely quantified in multiple samples such as those representing differentially perturbed cell states. The high degree of reproducibility required for such experiments has not been achieved by classical mass spectrometry-based proteomics methods. In this study we describe the implement

The conformational state of the pi-conjugated polyfluorene poly[9,9-bis(2-ethylhexyl)fluorene-2,7-diyl] is reconsidered. Contrary to the general opinion, this helical polymer is shown to organize in a giant repeat consisting of 21 monomer units. The length of the unit cell of 16.97 nm is suggested.

Presence of Stachybotrys chartarum in indoor environments has been linked to building-associated disease, however, the causative agents are unknown. Verrucarol (VER) and trichodermol (TRID) are hydrolysis products of some major S. chartarum mycotoxins, i.e. macrocyclic trichothecenes and trichodermin. We optimized gas chromatography-mass spectrometry (GC-MS) methods for detecting VER and TRID in S

Methods for measuring diffusion coefficients in gels are reviewed, and their capacities, limitations and requirements are briefly discussed. With four of these methods, i.e., the diaphragm cell, uptake/release from beads, holographic laser interferometry and nuclear magnetic resonance (FT-PGSE), a comparison is made with regard to accuracy and precision. The comparison is based on a number of stud

Rising atmospheric CO2 and temperatures are probably altering ecosystem carbon cycling, causing both positive and negative feedbacks to climate. Below-ground processes play a key role in the global carbon (C) cycle because they regulate storage of large quantities of C, and are potentially very sensitive to direct and indirect effects of elevated CO2 and temperature. Soil organic matter pools, roo

Using a variety of dedicated surface sensitive techniques, we studied the interaction of hydrogen with bare and adsorbate modified RuO2(110) surfaces on the atomic scale. Hydrogen interacts strongly with the undercoordinated O atoms, thereby forming hydroxyl groups and passivating available oxygen species on the oxide surface, for instance, for the catalytic CO oxidation reaction. Temperature prog

Second forerunner approximations to the transmission and reflection kernels for a temporally dispersive, nonmagnetic, isotropic slab are obtained. Numerical results are presented for two different dispersion models and are compared with the second forerunner approximations. Finally, transmission and reflection kernels are used to reconstruct the first susceptibility moments of the material of the