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Background: Human breast cancer most frequently originates within a well-defined anatomical structure referred to as the terminal duct lobular unit (TDLU). This structure is endowed with its very own lobular fibroblasts representing one out of two steady-state fibroblast subtypes—the other being interlobular fibroblasts. While cancer-associated fibroblasts (CAFs) are increasingly appreciated as co

The discovery of collective effects in small collision systems has spurred a renewed interest in hadronization models, and is also a source for collective effects all the way to large collision systems, where they are usually ascribed to the creation of a Quark–Gluon Plasma. In this topical mini-review, the microscopic model for string interactions, based on the Lund string hadronization model, de

John L. Schellenberg has suggested that we should guide the evolution of religion towards the goal of discovering the truth about transcendent reality. I argue that we need some way of discerning progress if this project is to be practically feasible. I explore what discernible progress would require in some possible future scenarios. Focus lies on scenarios involving improved cognitive contact wi

Purpose: To describe the rationale and design of the VOYAGER (NCT05476926) study, which aims to investigate the safety and effectiveness of faricimab and the Port Delivery System with ranibizumab (PDS) for neovascular age-related macular degeneration (nAMD) or diabetic macular edema (DME) in clinical practice. VOYAGER also aims to understand drivers of clinical practice treatment outcomes by gaini

We report on the precise radial velocity follow-up of TOI-544 (HD 290498),ã bright K star ( V = 10.8), which hostsã small transiting planet recently disco v ered by the Trãnsiting Exoplanet Survey Satellite (TESS) . We collected 122 high-resolution High Accuracy Radial velocity Planet Searcher (HARPS)ãnd HARPS-N spectra to spectroscopically confirm the transiting planetãnd measure its mass. The ne

Investigation of the dynamics of colloids in bulk can be hindered by issues such as multiple scattering and sample opacity. These challenges are exacerbated when dealing with inorganic materials. In this study, we employed a model system of Akaganeite colloidal rods to assess three leading dynamics measurement techniques: 3D-(depolarized) dynamic light scattering (3D-(D)DLS), polarized-differentia

This work investigates the impact of pilot flame and fuel composition on the structures and stabilization of swirling turbulent premixed methane/hydrogen/air flames in a lab-scale gas turbine model combustor. Simultaneous measurements of the velocity field and OH radicals distribution in the combustor were conducted using particle imaging velocimetry (PIV) and planar laser-induced fluorescence (PL

Globally we are facing a complex web of grand challenges that are impacting the lived environment, our development pathways, and wider quality of life. Urban environments serve as a key context around which these grand challenges are not only experienced while also providing multiple opportunities to reduce environmental impacts and resource consumption; improve health outcomes; eradicate poverty;

Avhandlingen är en sammanläggning av fyra artiklar om universell utformning i praktiken. Att designa för alla människor är en vägledande princip som Sveriges riksdag och regering beslutat om som del av implementeringen av FN:s konvention om rättigheter för personer med funktionsnedsättning. Avhandlingen bidrar med kunskap om förståelse, genomförande och samskapande gällande universell utformning. The thesis is a compilation of four articles and deals with Universal design in practice. This concept for designing for all is according to the Swedish Parliament and Government a guiding principle for the society. It is part of the implementation of the UN Convention on the Rights of Persons with Disabilities. The thesis contributes with knowledge about the understanding, implementation and co-c

To complete a new Swedish railway line in a much shorter timeframe than today, alter natives to the traditional methods need to be explored. One option is the use of prefabricated concrete slabs elevated on piers, analogous to the concept used in China for building new railways in record time (He et al., 2017). The method has the advantage of directly tackling the barrier effects exhibited by trad

When I intend to J, I may be wrong about what I intend but not about who intendsit. In this sense, action intentions appear immune to error. A standard explanationof this immunity is that the subject of the intention is not represented in the contentof the intention in the first place. When I think that we intend to J, it seems obviousthat I can misjudge who ‘we’ are. This may seem to indicate tha

Across the world, so-called warlord democrats (WDs) – former military or political leaders of armed groups who subsequently enter formal electoral politics – strongly influence the dynamics and trajectory of post-civil war politics. However, scholarship on war-to-peace transitions and post-conflict politics have often failed to pay attention to the agency of these important actors. This article re

Denna studie undersöker hur äldreboenden presenterade sina verksamheter på Instagram under covid-19-pandemins första år, genom kvalitativ analys av fyra intervjuer med företrädare för äldreboenden, samt 1748 bilder från två Instagramkonton.Resultatet visar att medan boendenas företrädare i intervjuerna beskrev år 2020 som kaosartat, presenterades livet på äldreboendena på Instagram som aktivt och

BackgroundThe problem with substandard and falsified (SF) medical products may grow in high-income countries when e-commerce of medicines increases. Unauthorized websites offer medicines of insufficient quality. This underscores the importance of evaluating how the problem with SF medical products can be prevented from escalating. However, little is known about what knowledge and experience profes

How may a “craft-orientation” facilitate a shift toward an ecologically sustainable economy that does not perceive the pursuit of economic growth as a self-evident good? Responding to this question, this paper is rooted in the argument that efforts to increase economic growth collide with ecological sustainability goals and pose a substantial threat to human prosperity. Drawing on key insights fro

Ensuring that the existing social inequalities of the current energy system are not transferred to the new system is crucial for the transition towards a low-carbon economy. This is the domain of energy justice—a normative and evaluative framework that has been applied extensively throughout the past decade for understanding the perspective of disadvantaged energy users. However, less attention ha

Money is central to capitalism and to our many sustainability crises. Could we remake money so as to advance sustainable economies and fair societies? A growing number of scholars, politicians, and activists think we can, and they are doing it from the bottom up. This book examines how grassroots groups, municipalities and radical crypto-entrepreneurs are remaking money by designing and organising