Adult growth hormone deficiency (GHD) is a multifactorial disorder in which pituitary dysfunction associated with pituitary adenomas or their treatment plays a major role. The introduction of recombinant growth hormone (GH) for the treatment of GHD has opened up new treatment avenues but has also raised concerns about possible untoward long-term metabolic effects of GH, such as the potential effec

Popular Abstract in Swedish Uppsatsskrivningen i läroverket har ofta beskrivits på ett negativt sätt: ensidig ämnesgivning, onaturliga skrivsituationer och bristfällig förberedande undervisning. Syftet med denna avhandling är att ta reda på om denna bild av praktiken haft en motsvarighet i teorin eller om det i stället funnits mer ambitiösa och varierade mål för skrivträningen. De material som redThis dissertation is about the goals that existed for Swedish essay writing in grammar schools from the start of the nineteenth century to the 1960s. The point of departure is the contrast between the negative image often painted of this essay writing and the positive picture painted of writing tuition before this period (classical rhetoric) and after it (process-oriented writing with the emphasis

A reduced protein model with five to six atoms per amino acid and five amino acid types is developed and tested on a three-helix-bundle protein, a 46-amino acid fragment from staphylococcal protein A. The model does not rely on the widely used Go approximation, which ignores non-native interactions. We find that the collapse transition is considerably more abrupt for the protein A sequence than fo

Studiecirklar har haft en stor betydelse för arbetarrörelsen, liksom för många andra folkrörelser, under 1900-talet. De var viktiga verktyg för att kunna vara samhällsengagerad och vara med och ta ansvar för det man ansåg vara av ett gemensamt intresse. Att vara med och ta ett ansvar för det gemensamt angelägna och besätta politiska poster runt om i kommunerna krävde kunskap om den kommunala verks

Myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis (EAE) is an inflammatory disease in rats that closely mimics many clinical and histopathological aspects of multiple sclerosis. Non-MHC quantitative trait loci regulating myelin oligodendrocyte glycoprotein-induced EAE have previously been identified in the EAE-permissive strain, DA, on rat chromosomes 4,10,15, a

Background: Clearance of tissue granulocytes is central to the resolution of airway inflammation. To date the focus has been on apoptotic mechanisms of cell removal and little attention has been given to alternative processes. The present study explores transepithelial migration as a mechanism of cell clearance. Method: Guinea pig tracheobronchial airways where eosinophils are constitutively pres

The reconstruction of extensive tracheal defects is still an unsolved challenge for thoracic surgery. Tissue engineering is a promising possibility to solve this problem through the generation of an autologous tracheal replacement from patients' own tissue. Therefore, this study investigated the potential of three different coculture systems, combining human respiratory epithelial cells and human

Stories that the audience can influence (such as computer games and other interactive multimedia), in contrast to 'traditional' stories (such as books and cinema), present a challenge to fields which take narrative (story) as their study object. What is the difference between these two kinds of stories? Earlier theories have focused on differences in media, structure, or the audience's physical ac

Latent autoimmune diabetes in adults (LADA) is a special form of diabetes that is clinically similar to type 2 diabetes but with positivity for pancreatic autoantibodies. The frequency of LADA patients among all patients diagnosed as type 2 varies between 6-50% in various populations. The frequency is higher in younger age groups. It is clear, however, that the frequency of autoimmune diabetes amo

Purpose: To study the effect of inhaled corticosteroid (ICS) on bone mineral density (BMD) in an observational longitudinal study. Methods: In 1995-97, as part of the Nord-Trondelag Health Study, Norway, 10,941 subjects aged 20yr or more, either reporting asthma diagnosis/asthma-related symptoms or randomly selected, were interviewed, underwent spirometry and had their forearm BMD assessed. Among

According to a previous study, 8% of all children in Dalby primary care district were chronically ill. The impact of the illness on the children's well-being was investigated using parental questionnaires. No difference in socio-demographic variables was found between responders (70%) and non-responders. The study comprised 98 index and 168 control children. Comfort and well-being in school and pr

The effect of core polarization on the oscillator strength for the resonance transition in neutral zinc is investigated using the multiconfiguration Hartree Fock approach. The use of model potentials and corrections to the dipole operator is compared to a method, where the core polarization is represented by including configuration state functions, with one hole in the 3d core subshell in the CI-e

In a 24-year sub-sample taken from a 42-year period of study (1950-1991), hip fracture incidence was analysed from a defined catchment area within one hospital. During this time, 8,256 hip fractures occurred in a generated risk population of 1,915,571 person-years. Crude incidence increased three-fold in women and five-fold in men. In men, the age-specific increase was twice as large as the age dr

Objectives To develop flexible classifiers that predict malignancy in adnexal masses using a large database from nine centers. Methods The database consisted of 1066 patients with at least one persistent adnexal mass for which a large amount of clinical and ultrasound data were recorded. The outcome of interest was the histological classification of the adnexal mass as benign or malignant. The out