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A new rectal model for dosimetry applications

A revised geometric representative model of the lower part of the colon, including the rectum, the urinary bladder and prostate, is proposed for use in the calculation of absorbed dose from injected radiopharmaceuticals. The lower segment of the sigmoid colon as described in the 1987 Oak Ridge National Laboratory mathematical phantoms does not accurately represent the combined urinary bladder/rect

Drug-related problems in the elderly - Interventions to improve the quality of pharmacotherapy

Popular Abstract in Swedish Läkemedelsrelaterade problem hos äldre - Interventioner för att förbättra läkemedelsbehandlingen Läkare inom primärvården står för en stor del av den totala läkemedelsförskrivningen i Sverige och är en viktig målgrupp för läkemedelsindustrins information. Det har i flera uppmärksammade studier från Socialstyrelsen uppmärksammats att läkemedelsbehandlingen för patientIntroduction: Elderly people, in particular those residing in nursing homes, often use many drugs. In general elderly patients are at greater risk of experiencing drug-related problems (DRP), as they have multiple diseases, are using many drugs and have changed physiological status. Objectives: To describe the frequency of potential drug-related problems in the elderly and to evaluate different k

Multivariate Optimization and Mechanistic Considerations of the Amine Induced Ring-Opening Reaction of 2-Alkyl-3-bromo-5-methylthiophene-1,1-dioxides

In the optimization of the ring-opening reaction of thiophene-1,1-dioxides, 3-bromo-2,5-dimethylthiophene-1,1-dioxide (1) and 2-(2-hydroxyethyl)piperidine (7) were chosen as model reagents. Solvent, temperature, molar ratio between amine and dioxide and the amount of solvent were variables included in the optimization. A central composite design was chosen for the investigation and a canonical ana

Microbial Desulfurization of Coal by T. ferrooxidans and Thermophilic Archaea

Several different microorganisms have been suggested for coal desulfurization. In the present investigation, the thermophilic archaea Acidianus brierleyi (DSM 1651), Sulfolobus acidocaldarius (DSM 639) and Sulfolobus solfataricus (DSM 1616) were compared with the mesophilic bacterium Thiobacillus ferrooxidans (DSM 583) concerning their capability of removing sulfur from coal. The desulfurization r

Rättvisa prioriteringar inom hälso- och sjukvård - etiska teorier och jämförelser med prioriteringsutredningens principer

Frågan om hur prioriteringar bör göras inom sjukvården har under de senaste decennierna blivit allt mer diskuterad, både internationellt och i Sverige. År 1995 publicerades i Sverige en offentlig utredning med titeln "Vårdens svåra val" som behandlar dessa frågor. I utredningen presenterades följande tre etiska principer som en grund för prioriteringar: människovärdighetsprincipen, behovs- eller s

Detection of Escherichia coli in water by culture-based amperometric and luminometric methods.

The application of amperometric biosensor- and chemiluminiscence based methods for rapid detection of viable E. coli in water has been investigated. An amplification of the amperometric signal by a factor of 4 was obtained when the cellobiose dehydrogenase (CDH) biosensor was used instead of a plain graphite electrode for detection of b-galactosidase (b-GAL) activity at 22.5 degrees C. A linear co

Tulasnein and podospirone from the coprophilous xylariaceous fungus Podosordaria tulasnei

Tulasnein (1), a new metabolite with strong antimicrobial and weaker cytotoxic and phytotoxic activity, was isolated from culture filtrates of three strains of the xylariaceous coprophilous fungus Podosordaria tulasnei. The producing strains were identified by their rhizomorphs and by ITS rDNA sequence analysis. A second new metabolite, podospirone (2), was also produced by all three strains where

Cardioprotection by estrogens: mechanisms of action--the lipids

Reductions of total and LDL-cholesterol and, to a lesser extent, increase in HDL are known to decrease cardiovascular disease (CVD) incidence. All oral estrogens are known to induce such changes in a dose-dependent manner at doses commonly used in ERT, somewhat more markedly for estradiol than for conjugated equine estrogens (CEE). Low-dose estriol used for urogenital discomfort is void of lipid e

Mutation analysis and clinical implications of von Willebrand factor-cleaving protease deficiency.

Background. The pentad of thrombocytopenia, hemolytic anemia, mild renal dysfunction, neurologic signs, and fever, classically characterizes the syndrome of thrombotic thrombocytopenic purpura (TTP). TTP usually occurs in adults as an acquired form but a congenital form in children has also been described. In the latter case, the initial presentation is often with neonatal jaundice and thrombocyto

Population-attributable risk of coronary heart disease risk factors during long-term follow-up: the Malmö Preventive Project.

Aims To calculate the population-attributable risk (PAR) of coronary events (CE) from 10 risk factors, during long-term follow-up. Methods We used both case-cohort and case-control analyses for calculation of PAR in relation to 10 baseline risk factors. First CE (fatal or nonfatal, n = 3072) in 22 444 males and 10 902 females was recorded during a mean follow-up of 20 years by use of national regi

Use of a geomorphological transfer function to model design floods in small hillside catchments in semiarid Tunisia

In the beginning of the 1990s, the Tunisian Ministry of Agriculture launched an ambitious program for constructing small hillside reservoirs in the northern and-central region of the country. At present, more than 720 reservoirs have been created. They consist of small compacted earth dams supplied with a, horizontal overflow weir. Due to lack of hydrological data and the area's extreme floods, ho

Balanced partition of minimum spanning trees

To better handle situations where additional resources are available to carry out a task, many problems from the manufacturing industry involve dividing a task into a number of smaller tasks, while optimizing a specific objective function. In this paper we consider the problem of partitioning a given set S of n points in the plane into k subsets, S-1,...,S-k, such that max(1less than or equal toil

MnAs dots grown on GaN( 000(1)over-bar)-(1x1) surface

MnAs has been grown by means of MBE on the GaN(000 (1) over bar)-(1x1) surface. Two options of initiating the crystal growth were applied: (a) a regular MBE procedure (manganese and arsenic were delivered simultaneously) and (b) subsequent deposition of manganese and arsenic layers. It was shown that spontaneous formation of MnAs dots with the surface density of 1x10(11) cm(-2) and 2.5x10(11) cm(-