Identifying cellular programs that drive cancers to be stem-like and treatment resistant is critical to improving outcomes in patients. Here, we demonstrate that constitutive extracellular signal-regulated kinase 1/2 (ERK1/2) activation sustains a stem-like state in glioblastoma (GBM), the most common primary malignant brain tumor. Pharmacological inhibition of ERK1/2 activation restores neurogene

Customer engagement is one of the hottest topics in the customer management area. Most of the customer engagement research focus on the customer with strong psychological connection with the focal object, however, the customer who is driven by external benefits, such as discounts and sense of being needed, also contribute significant engagement value to the firm. This paper proposes the constructs

Fabrication of silicon carbide fibres reinforced silicon carbide composite (SiC/SiC) by chemical vapour infiltration (CVI) process was investigated in this research with the help of both simulation and experimental set-up. CVI of silicon carbide preform was carried out through the pyrolysis of methyltrichlorosilane (MTS) over a broad temperature range at atmospheric pressure. The overall aim was t

Real raw municipal wastewater is treated abiotic in combination of chemical and mechanical treatment with microfiltration as the final treatment step. This rather new treatment concept is described as direct membrane filtration and has been tested in a smaller scale in Sweden. The presented concept in this study is significantly larger (386 times) and is built in Norway to compare both studies per

Whole-genome sequencing (WGS) brings comprehensive insights to cancer genome interpretation. To explore the clinical value of WGS, we sequenced 254 triple-negative breast cancers (TNBCs) for which associated treatment and outcome data were collected between 2010 and 2015 via the population-based Sweden Cancerome Analysis Network-Breast (SCAN-B) project (ClinicalTrials.gov ID:NCT02306096). Applying

Background: Biomarker-based risk predictions of dementia in people with mild cognitive impairment are highly relevant for care planning and to select patients for treatment when disease-modifying drugs become available. We aimed to establish robust prediction models of disease progression in people at risk of dementia. Methods: In this modelling study, we included people with mild cognitive impair

The primary function of cyclin-dependent kinases (CDKs) in complex with their activating cyclin partners, is to promote mitotic division in somatic cells. This canonical cell cycle-associated activity is also crucial for fertility as it allows the proliferation and differentiation of stem cells within the reproductive organs to generate meiotically competent cells. Intriguingly several CDKs exhibi

Over 840 M ha of arable land is affected by salinization, and the area is predicted to increase due to global change. Assessments of the status of the microbial community in saline soils have frequently been based on microbial biomass estimates, which might not accurately reflect microbial process rates in soil. Moreover, assessments of how the relative importance of major decomposer groups bacter

Regional Student Groups (RSGs) of the International Society for Computational Biology Student Council (ISCB-SC) have been instrumental to connect computational biologists globally and to create more awareness about bioinformatics education. This article highlights the initiatives carried out by the RSGs both nationally and internationally to strengthen the present and future of the bioinformatics

In spite of the fact that negation has been the focus of many studies, the way it is processed in human communication still eludes us. Previous studies of negation using event-related potentials (ERPs) have reported inconclusive results as to whether or not negation poses difficulties for processing. While some have found that negation is initially ignored and incongruities in negated sentences do

Energy efficiency is a priority goal and an important part of the transformation to a more sustainable society. The industrial sector is an important actor in this setting. In this chapter we outline the major principles for energy efficiency and energy management in industry and discuss how to develop the energy management perspective with theories from social science focusing on how situated actEnergy efficiency is a priority goal and an important part of the transformation to a more sustainable society. The industrial sector is an important actor in this setting. In this chapter we outline the major principles for energy efficiency and energy management in industry and discuss how to develop the energy management perspective with theories from social science focusing on how situated act

Högskoleutbildningarna inom det konstnärliga området är mångfasetterade och täcker många konstformer inom musik, dans, teater, cirkus, bild, foto, design, konsthantverk, textil, arkitektur, skrivande, för att bara nämna några. Uttrycken är publika, ofta förankrade i historia och tradition men även i ständig omförhandling med rådande samhällsdiskurser och kulturpolitik. Med boken Konstuniversitetet

Aims: Abdominal aortic aneurysm is a life-threatening condition due to the risk of aneurysm growth and rupture. There are no approved diagnostic or prognostic biomarkers for abdominal aortic aneurysm. We aimed to identify diagnostic and prognostic biomarkers for abdominal aortic aneurysm and to investigate their relationship with abdominal aortic aneurysm diameter and growth. Methods: In this case

Background: Lung cancer is one of the most common cancers in the world. Early detection and correct staging are fundamental for treatment and prognosis. Positron emission tomography with computed tomography (PET/CT) is recommended clinically. Silicon (Si) photomultiplier (PM)-based PET technology and new reconstruction algorithms are hoped to increase the detection of small lesions and enable earl

Since music education can be regarded as an arena for construction, performance and negotiation of cultural meaning and norms of values, the field of music education has, during the last decades, become aware of the need to locate issues of facing music within social questions (Jorgensen, 2003; DeNora, 2000; Wright, 2010). One central concept within this discussion is social inclusion. However, is

(equation presented) The synthesis of α-substituted α,β-enones by a new metal iodide-promoted one-pot three-component reaction involving commercially available cyclopropyl ketones, aldehydes, and secondary amines followed by base treatment is described.