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Glucagon, secreted by the pancreatic alpha-cells, stimulates insulin secretion from neighboring beta-cells by cAMP- and protein kinase A (PKA)-dependent mechanisms, but it is not known whether glucagon also modulates its own secretion. We have addressed this issue by combining recordings of membrane capacitance (to monitor exocytosis) in individual alpha-cells with biochemical assays of glucagon s

Spray drying is a widely used process to produce pharmaceutical powders. In traditional spray drying, the particle size distribution is wide and not well controlled. Using EHD atomization for spray drying offers a possibility to tailor the particle size and morphology. In conventional EHD spray drying, the generated particles are charged and need to be discharged to avoid Rayleigh breakup. Dischar

The development of underwater profiles and sand losses from the dune respectively the beach by various water level and wave conditions has been studied worldwide in large wave flumes since 1955. Virtually all major results collected over the last decades are documented and described in this paper. Moreover, to this overview results from the MAST III-SAFE experiments, carried out in the Grosser Wel

New radiative lifetimes, measured by time-resolved laser-induced fluorescence spectroscopy, are reported for five Rydberg states of singly ionized ytterbium. Free Yb+ ions were produced in a laser-induced plasma. The experimental results have been compared with HFR calculations, taking core-polarization effects into account, and a good agreement (within 25%) between theory and experiment is observ

No generally accepted definition of osteoarthritis exists. Traditionally, the diagnosis is obtained by radiographic examination but different definitions are used for different purposes. Since no causal treatment exists, treatment is aiming at reducing symptoms and improving function. The correlation between radiographic features of osteoarthritis and symptoms is poor. Thus, it is recommended that

The topological group D-k(S) of diffeomorphisms of the unit circle 5 of Sobolev class H-k, for k large enough, is a Banach manifold modeled on the Hilbert space H-k(S). In this paper we show that the H-1 right-invariant metric obtained by right-translation of the H-1 inner product on TidDk(S)similar or equal to H-k(S) defines a smooth Riemannian metric on D-k(S), and we explicitly construct a comp

Boswellic acids are the compounds isolated from the gum resin of Boswellia serrata and have been used for the treatment of inflammatory diseases for many years in the countries of the east. Recently, a few studies showed that the acids may have anti-cancer effect on leukemia and brain tumours. We investigated the apoptotic and anti-proliferative effects of two types of boswellic acids, keto-beta-b

We present the magnetotransport properties of very thin (5-15 nm) single (Ga,Mn)As layers grown by low-temperature molecular beam epitaxy. A lower (Ga,Mn)As thickness limit of 5 nm for the ferromagnetic phase and the dependence of the Curie temperature on (Ga,Mn)As thickness are determined from electrical-transport measurements. The Curie temperature is determined to be 97 K for the thinnest ferro

Some children with autism and learning disabilities also have aberrant behaviours that are difficult to regulate and stressful for both the child and family members. This case study concerns experiences of 10 parents from five families before and 2 years after entrusting their 10- to 11-year-old child with autism to a group home. Hermeneutic phenomenological analysis of narrative interviews with t

Sorption of vapors of water, ethanol, and other liquids on solids like pharmaceuticals, textiles and food stuffs are of both practical and theoretical importance. In this article we present a technique to simultaneously measure sorption isotherms and sorption enthalpies. The sample is contained in one end of a sorption vessel. In the other end a vaporizable liquid is introduced to start the measur

The prognostic value of distal blood pressure measurements has been studied in 314 consecutive diabetic patients with foot ulcers. Systolic toe blood pressure was measured with a strain-gauge technique, and ankle pressure was measured with strain-gauge or Doppler techniques. Wound healing was defined as intact skin for at least 6 mo. One hundred ninety-seven patients healed primarily, 77 had amput

Neuropsychological sex differences have since long been under debate. Support for the relation between behavioral differences and biological variables like hormone influence is, however, emerging. Sixteen men and sixteen women, all university students, were tested with computerized neuropsychological tests (APT), the Bem Sexual Role Inventory, and asked about pubertal age. The results were in line

Human semen has several important constituents, including the prostate secreted proteins beta-microseminoprotein (MSP), prostate-specific antigen (PSA) and prostatic acid phosphatase (PAP), and the seminal-vesicle-derived coagulum proteins semenogelin I (SEMG1) and semenogelin II (SEMG2). The research underlying this thesis explored the evolution, expression and structure of seminal plasma protein

The Role of women in medieval and early modern England