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Dynamic effects on cutting forces with highly positive versus highly negative cutting edge geometries

Understanding the influence of the cutting edge geometry on the development of cutting forces during the milling process is of high importance in order to predict the mechanical loads on the cutting edge as well as the dynamic behavior on the milling tool. The work conducted in this study involves the force development over the entire engagement of a flute in milling, from peak force during the en

No more faith in fakes : A natural history of counterfeiting

Commenting on Eco's papers about fakes, I claimed that what is meant by a fake depends on what is taken to be the original, and this, in turn, revolves around the relation between type and token. As observed by Prieto and Grice, a sign, apart from the content it conveys, also carries a message informing us that it is a sign. The scare crow is a sign to the addresser, but not, ideally, to the addre

MIMO Nyquist interpretation of the large gain theorem

The Large Gain Theorem is an input-output stability result with intriguing applications in the field of control systems. This paper aims to increase understanding and appreciation of the Large Gain Theorem by presenting an interpretation of it for linear time-invariant systems using the well-known Nyquist stability criterion and illustrative examples of its use. The Large Gain Theorem is complemen

Shocked quartz grains in the early Cambrian Vakkejokk Breccia, Sweden—Evidence of a marine impact

Here we present a study of the abundance and orientation of planar deformation features (PDFs) in the Vakkejokk Breccia, a proposed lower Cambrian impact ejecta layer in the North-Swedish Caledonides. The presence of PDFs is widely accepted as evidence for shock metamorphism associated with cosmic impact events and their presence confirms that the Vakkejokk Breccia is indeed the result of an impac

Predicting Relative Binding Affinity Using Nonequilibrium QM/MM Simulations

Calculating binding free energies with quan-tum-mechanical (QM) methods is notoriously time-consum-ing. In this work, we studied whether such calculations can beaccelerated by using nonequilibrium (NE) moleculardynamics simulations employing Jarzynski’s equality. Westudied the binding of nine cyclic carboxylate ligands to theocta-acid deep-cavity host from the SAMPL4 challenge withthe reference po

Search for Isovector Valence-Shell Excitations in 140Nd and 142Sm via Coulomb excitation reactions of radioactive ion beams

Projectile Coulomb excitation experiments were performed at HIE-ISOLDE at CERN with the radioactive ion beams of 140Nd and 142Sm. Ions with an energy of 4:62 MeV/A were impinging on a 1.45 mg/cm2 thick 208Pb target. The γ-rays depopulating the Coulomb-excited states were recorded by the HPGe-array MINIBALL and scattered particles were detected by a double-sided silicon strip detector. Experimental

Digital Recruitment and Acceptance of a Stepwise Model to Prevent Chronic Disease in the Danish Primary Care Sector : Cross-Sectional Study

BACKGROUND: During recent years, stepwise approaches to health checks have been advanced as an alternative to general health checks. In 2013, we set up the Early Detection and Prevention project (Tidlig Opsporing og Forebyggelse, TOF) to develop a stepwise approach aimed at patients at high or moderate risk of a chronic disease. A novel feature was the use of a personal digital mailbox for recruit

Vertical Gate-All-Around Nanowire GaSb-InAs Core-Shell n-Type Tunnel FETs

Tunneling Field-Effect Transistors (TFET) are one of the most promising candidates for future low-power CMOS applications including mobile and Internet of Things (IoT) products. A vertical gate-all-around (VGAA) architecture with a core shell (C-S) structure is the leading contender to meet CMOS footprint requirements while simultaneously delivering high current drive for high performance specific

Uppåkra

Gudme [p. 693]; Himlingøje [p. 723]; Lundeborg [p. 926]; Skedemosse [p. 1393]; Vorbasse [p. 1574]; Uppåkra [p. 1541]

Sex influences DNA methylation and gene expression in human skeletal muscle myoblasts and myotubes

Background: Sex differences are known to impact muscle phenotypes, metabolism, and disease risk. Skeletal muscle stem cells (satellite cells) are important for muscle repair and to maintain functional skeletal muscle. Here we studied, for the first time, effects of sex on DNA methylation and gene expression in primary human myoblasts (activated satellite cells) before and after differentiation int

In Vitro Functional Characterization of Human Neurons and Astrocytes Using Calcium Imaging and Electrophysiology

Recent progress in stem cell biology and epigenetic reprogramming has opened up previously unimaginable possibilities to study and develop regenerative approaches for neurological disorders. Human neurons and glial cells can be generated by differentiation of embryonic and neural stem cells and from somatic cells through reprogramming to pluripotency (followed by differentiation) as well as by dir

David Hume e Adam Smith : Riflessioni su un libro

Abstract in ItalianNel 2017 Dennis C. Rasmussen ha pubblicato The Infidel and the Professor: David Hume, Adam Smith, and the Friend-ship that Shaped Modern Thought (Princeton-Oxford, Princeton University Press). Si tratta di uno studio destinato a suscitare un vivace dibattito sia per quel che concerne la re-visione dell’immagine canonica dei due filosofi, sia per le implicazioni teoriche ad essa

Measurement of the azimuthal anisotropy of charged particles produced in √sNN = 5.02 TeV Pb+Pb collisions with the ATLAS detector

Measurements of the azimuthal anisotropy in lead–lead collisions at sNN = 5.02 TeV are presented using a data sample corresponding to 0.49 nb - 1 integrated luminosity collected by the ATLAS experiment at the LHC in 2015. The recorded minimum-bias sample is enhanced by triggers for “ultra-central” collisions, providing an opportunity to perform detailed study of flow harmonics in the regime where

Pupil motivation and school-related stress: Influences from teachers

An important factor in pupils’ learning is the teacher’s qualities of being responsive, permissive and structured, and to see, understand and appropriately respond to the pupils’ feelings. This study examined the relation between teacher emotional intelligence, defined as “the ability to use emotions to facilitate thought, perceive, understand and manage one’s own and others emotions”, teacher wor

Museum as Activist: (Re)inventing Institutional Paradigm at the Museum of Movements in Malmö

Vad händer bakom museimontrar och magasindörrar? Vem bestämmer vilket kulturarv som ska bevaras och vilken del av det ska utställas? Vem driver det osynliga maskineriet av museernas backstage-funktioner och genomför dagliga museirutiner? Museer som modernitetsinstitutioner har en särskild roll i processen för kunskapsproduktion och maktfördelning inom samhällen, först och främst genom att synliggöWhat exactly happens behind museum displays and repository doors? Who decides what heritage has to be preserved and what part of it should be exhibited? Who operates all this invisible machinery of the museums’ backstage functions and executes its daily routines? Museums as institutions of modernity have a specific role in the process of knowledge production and power redistribution within societi