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A colorful death : A study of the social life of colors in Late Bronze Age grave goods

The study of burials can include, among other things, examinations of grave goods, architecture, osteological and organic remains, context and location, socio-religious and ritual importance, sacred landscape, socio-economic relevance, and so on. One area that has not been investigated in depth regarding the objects placed in the graves is the aspect of color: does their color in general or specifi

Harnessing androgen receptor pathway activation for targeted alpha particle radioimmunotherapy of breast cancer

Purpose: The impact of androgen receptor (AR) activity Results: D-Norgestrel and DHT activated the AR pathway, in breast cancer biology is unclear. We characterized and while 17b-Estradiol did not. Competitive binding for AR tested a novel therapy to an AR-governed target in breast protein showed similar affinity between DHT and D-Norges-cancer. trel, indicating direct AR–ligand interaction. In vi

A genetic risk score for hypertension is associated with risk of thoracic aortic aneurysm

A genetic risk score (GRS) based on 29 single nucleotide polymorpysms (SNPs) associated with high blood pressure (BP) was prospectively associated with development of hypertension, stroke and cardiovascular events. The aim of the present study was to evaluate the impact of this GRS on the incidence of aortic disease, including aortic dissection (AD), rupture or surgery of a thoracic (TAA) or abdom

Automatic identification of poorly performing substations and meter devices : The future of district heating

The district heating sector in Sweden is today facing several challenges due to competition from other heating alternativesas well as decreasing heat demand in buildings. To increase its competitiveness, the district heating companieshave to find ways to keep their production costs at a more or less constant level. One way of doing this is to increasethe efficiency of the district heating systems.The district heating sector in Sweden is today facing several challenges due to competition from other heating alterna-tives as well as decreasing heat demand in buildings. To increase its competitiveness, the district heating companieshave to find ways to keep their production costs at a more or less constant level. One way of doing this is to increasethe efficiency of the district heating system

Dose tailoring of adjuvant chemotherapy for breast cancer based on hematologic toxicities : further results from the prospective PANTHER study with focus on obese patients

Background: Adjuvant chemotherapy (ACT) for breast cancer improves relapse-free survival (BCRFS) and overall survival. Differences in terms of efficacy and toxicity could partly be explained by the significant interpatient variability in pharmacokinetics which cannot be captured by dosing according to body surface area. Consequently, tailored dosing was prospectively evaluated in the PANTHER trial

Sertraline in symptomatic chronic breathlessness : a double blind, randomised trial

Does sertraline provide symptomatic relief for chronic breathlessness in people with advanced disease whose underlying cause(s) are optimally treated?223 participants with chronic breathlessness (modified Medical Research Council breathlessness scale ≥2) who had optimal treatment of underlying cause(s) were randomised 1:1 to sertraline 25-100 mg (titrated upwards over 9 days) or placebo for 4 week

Spherical nanocomposite particles prepared from mixed cellulose-chitosan solutions

Novel cellulose-chitosan nanocomposite particles with spherical shape were successfully prepared via mixing of aqueous biopolymer solutions in three different ways. Macroparticles with diameters in the millimeter range were produced by dripping cellulose dissolved in cold LiOH/urea into acidic chitosan solutions, inducing instant co-regeneration of the biopolymers. Two types of microspheres, chemi

Gamma- and Fast Neutron- Sensitivity of 10B- Based Neutron Detectors at ESS

The European Spallation Source (ESS), presently under construction in Lund, Sweden, is designed to be the world's brightest neutron source. When it will be in operation, ESS will deliver an instantaneous neutron flux on detectors that will be without precedent. A down side of the high brightness will be the increase of background, especially from gamma-rays and fast-neutrons.Considering that scatt

Existential Questions in Research and Education in the Shape of a Response to Sven Hartman

Over the past 50 years, the concept existential question has played a less prominent role in upper secondary school curricula. The interpretation of the world view perspective has been retained until the curriculum 2000. Perspectives of personal development and interpretation of life in upper secondary school have almost disappeared. The syllabus has been content centred, reflective and analytical

Recension av Mattias Lundberg, Martin Luthers egna toner och ord om musik : Källtexter rörande musiken i Wittenbergreformationen i översättning med kommentarer och analys.

Avståndet till Luthers musikvärld är ansenligt. Kunskapen om reformatorns tolkning av musikens roll för människor, kyrka och samhälle har knappast utvecklats i aktuell forskning. Sådana kunskaper behövs dock, de är t.o.m. "högst centrala för [att förstå] Luthers tillvägagångssätt, och vågar jag påstå, också för hans framgång" påpekar Lundberg.

Konflikter i Västerns historia

Recension av Peter Skogsberg, Sökandet efter Sand Creek och andra essäer om relationen mellan indianer och vita i amerikansk historia

The semiotics of the game controller

An important question for video game research is how to characterize the video game experience. One common view emphasizes that players are cognitively able to operate with the game world as the experiential point of reference leading to states of "immersion, "spatial presence", or "engagement". A different view is that the player is also embodied and situated in the actual world, entailing that t

Single cell analysis of proliferation and movement of cancer and normal-like cells on nanowire array substrates

Nanowires are presently investigated in the context of various biological and medical applications. In general, these studies are population-based, which results in sub-populations being overlooked. Here, we present a single cell analysis of cell cycle and cell movement parameters of cells seeded on nanowires using digital holographic microscopy for time-lapse imaging. MCF10A normal-like human bre

B2B brand equity : investigating the effects of human capital and relational trust

Purpose: The purpose of this study is to investigate the effects of human capital and relational trust on business-to-business (B2B) brand equity. Design/methodology/approach: Data collection was conducted among the clients of one of the Big Four auditing firms in Sweden. Structural equation modeling was used to test the hypothesized effects. Findings: The results demonstrate positive effects of h

In-Cycle Closed-Loop Combustion Control with Pilot-Main Injections for Maximum Indicated Efficiency

An in-cycle closed-loop combustion controller is proposed in this paper. The controller uses a pilot-main injection scheme where the cycle-individual properties of the pilot combustion are estimated by in-cylinder pressure measurements, and used to predict their effect on the heat release shape of the main combustion. The prediction is used to obtain the optimal main SOI that gives the Maximum Rea

Spatial mapping of affinity changes for the integrin LFA-1 during cell migration using clusters identified based on local density

Localization microscopy methods like Stochastic Optical Reconstruction Microscopy (STORM) are very well suited for exploring clustering of proteins, as the data inherently provide a list of molecular coordinates. Here we use state-of-art cluster analysis algorithms (DBSCAN) to explore the clustering behaviour of different affinity forms of the integrin LFA-1. It has been suggested that LFA-1 may f

Domkyrkoentreprenaden : förspel, genomförande och avslutning

En berättelse om entreprenaden bakom byggandet av Lunds domkyrka. Den lokala aristokratins erfarenhet av entreprenader, anskaffandet av arbetskraft och Harald Blåtands första etablering i Lund inleder redogörelsen. Den första byggnaden på kyrkoplatsen, troligen ett kloster, får byggnadsmaterialet fråm Helsingborg- och Ystadstrakten. Den stående domkyrkans sten kommer från Hallaröd/Munkarp. En fyll