Sökresultat

Filtyp

Din sökning på "*" gav 529995 sökträffar

Octreotide SC depot in patients with acromegaly and functioning neuroendocrine tumors : a phase 2, multicenter study

Purpose: Octreotide SC depot is a novel, ready-to-use formulation administered via a thin needle. In a phase 1 study in healthy volunteers, this formulation provided higher bioavailability of octreotide with faster onset and stronger suppression of IGF-1 in healthy volunteers versus long-acting intramuscular (IM) octreotide. This phase 2 study evaluated the pharmacokinetics, efficacy, and safety o

Patient-reported outcome and experience measures for diabetes : development of scale models, differences between patient groups and relationships with cardiovascular and diabetes complication risk factors, in a combined registry and survey study in Sweden

PURPOSE: The Swedish National Diabetes Register (NDR) has developed a diabetes-specific questionnaire to collect information on individuals' management of their diabetes, collaboration with healthcare providers and the disease's impact on daily life. Our main objective was to develop measures of well-being, abilities to manage diabetes and judgements of diabetes care, and to detect and quantify di

The Uses of Justice in Global Perspective, 1600-1900

The Uses of Justice in Global Perspective, 1600–1900 presents a new perspective on the uses of justice between 1600 and 1900 and confronts prevailing Eurocentric historiography in its examination of how people of this period made use of the law.Between 1600 and 1900 the towns in Western Europe, the Kingdoms in Eastern Europe, the Empires in Asia and the Colonial States in Asia and the Americas wer

Cancer chromosome breakpoints cluster in gene-rich genomic regions

Cancer cells are characterized by chromosome abnormalities, of which some, in particular balanced rearrangements, are associated with distinct tumor entities and/or with specific gene rearrangements that represent important steps in the carcinogenic process. However, the vast majority of cytogenetically detectable structural aberrations in cancer cells have not been characterized at the nucleotide

Methods to Detect Loss of Lysosomal Membrane Integrity

Loss of lysosomal membrane integrity, often referred to as lysosomal membrane permeabilization (LMP), occurs in many instances of cell death either as an initiating or as an amplifying event. Currently, the best method for detecting LMP is the galectin puncta formation assay which can be used for a broad range of sample types, both fixed and live, is easy to perform, and highly sensitive. This met

Demokrati i komparativ belysning

recension av Demokratins drivkrafter. Kontext och särdrag i Finlands och Sveriges demokratier, (H. Meinander, P. Karonen & K. Östberg, red.), Helsingfors/Stockholm 2018

The practice of targeting visitors to urban destinations – a critical discussion of DMOs information strategies

How do you attract visitors to your city? How do you manage to be visible in the information flow for potential visitors? Urban Destination Marketing Organisations (DMO) operate in a fast changing environment with ongoing challenges to face. Digitalisation is one of the issues that DMOs have to handle. As a result, we can see that many tourism offices are closed down in Sweden. However, has new te

Microrheology of Concentrated Protein Solutions

Tack vare ett näst intill oändligt antal variationer så har proteiner blivit naturens standardlösning för diverse uppgifter och problem. I våra egna kroppar har vi en uppsjö av olika varianter där några är allmänt välkända, t.ex. hemoglobin i våra röda blodkroppar som transporterar runt syre och insulin vilket sänker vår blodsockernivå. Andra proteiner är mer okända men trots det lika viktiga, exeThe behavior of concentrated protein solutions is of general high interest due to implications in, for example, biological systems and medical applications. It is necessary to investigate the rheological properties of such systems to understand how parameters, such as stability, are affected by the high concentrations. Unfortunately, studies are often hindered by the lack of sufficient quantities