BACKGROUND: There is limited evidence of the effects of local anesthesia (LA) on outcomes of non-surgical periodontal treatment (NSPT), in particular among the Chinese. This retrospective cohort study aimed to evaluate the effects of LA on short-term treatment outcomes of NSPT and to determine under what circumstances LA should be prescribed to improve these outcomes. METHODS: Data from periodonta

Background: To systematically review the association between knee abduction kinematics and kinetics during weight-bearing activities at baseline and the risk of future anterior cruciate ligament (ACL) injury. Methods: Systematic review and meta-analysis according to PRISMA guidelines. A search in the databases MEDLINE (PubMed), CINAHL, EMBASE and Scopus was performed. Inclusion criteria were prosp

The dynamics of terrestrial ecosystems are shaped by the coupled cycles of carbon, nitrogen, and phosphorus, and these cycles are strongly dependent on the availability of water and energy. These interactions shape future terrestrial biosphere responses to global change. Here, we present a new terrestrial ecosystem model, QUINCY (QUantifying Interactions between terrestrial Nutrient CYcles and the

Objectives To examine the long term mortality associated with preterm delivery in a large population based cohort of women, and to assess for potential confounding by shared familial factors. Design National cohort study. Setting Sweden. Participants All 2 189 477 women with a singleton delivery in 1973-2015. Main outcome measures All cause and cause specific mortality up to 2016, identified from

5G communication systems operating above 24 GHz have promising properties for user localization and environment mapping. Existing studies have either relied on simplified abstract models of the signal propagation and the measurements, or are based on direct positioning approaches, which directly map the received waveform to a position. In this study, we consider an intermediate approach, which con

In Finland, forests are both one of the main national economic resources and the main source of biodiversity. Lack of detailed empirical evidence of how forestry affects biodiversity limits the development of sustainable forest management. Previous studies have found that the Northern goshawk (Accipiter gentilis) is a keystone species in mature coniferous boreal forests, and that its presence is a

Vegetation nutrient limitation is essential for understanding ecosystem responses to global change. In particular, leaf nitrogen (N) is known to be plastic under changed nutrient limitation. However, models can often not capture these observed changes, leading to erroneous predictions of whole‐ecosystem stocks and fluxes.We hypothesise that an optimality approach can improve representation of leaf

Medulloblastoma is the most common malignant brain tumor in children. Here we describe a medulloblastoma model using Induced pluripotent stem (iPS) cell-derived human neuroepithelial stem (NES) cells generated from a Gorlin syndrome patient carrying a germline mutation in the sonic hedgehog (SHH) receptor PTCH1. We found that Gorlin NES cells formed tumors in mouse cerebellum mimicking human medul

Plant–soil interactions, such as the coupling of plants' below-ground biomass allocation with soil organic matter (SOM) decomposition, nutrient release and plant uptake, are essential to understand the response of carbon (C) cycling to global changes. However, these processes are poorly represented in the current terrestrial biosphere models owing to the simple first-order approach of SOM cycling

A series of experimental measurements on a prototype premixed swirl burner with complex geometry were carried out using CH2O/OH-PLIF. FGM method(SFGM)taking account of strain rate was developed to study two modes of premixed swirl flame, one stabilized and the other close to blown-off flame under the same Reynolds number(Re=10000). The SFGM model in this work is related to a reaction factor, which

BACKGROUND: Severe asthma exerts a disproportionately heavy burden on patients and health care. Due to the heterogeneity of the severe asthma population, many patients need to be evaluated to understand the clinical features and outcomes of severe asthma in order to facilitate personalised and targeted care. The International Severe Asthma Registry (ISAR) is a multi-country registry project initia

Staphylococcal toxic shock syndrome is a potentially lethal illness attributed to superantigens produced by Staphylococcus aureus, in particular toxic shock syndrome toxin 1 (TSST-1), but staphylococcal enterotoxins (SEs) are also implicated. The genes encoding these important toxins are carried on mobile genetic elements, and the regulatory networks controlling expression of these toxins remain r

The sun is the most important energy source for the Earth’s climate system, however, influences of solar variations on climate are not fully understood. Studying past solar activity can improve our understanding of what role the sun plays in Earth’s climate. Cosmogenic radionuclides, such as 10Be in ice cores, are powerful tools to reconstruct past solar activity before the period of direct telesc

Oscillatory neural activity in the cortico-basal ganglia-thalamocortical (CBGTC) loop is associated with the motor state of a subject, but also with the availability of modulatory neurotransmitters. For example, increased low-frequency oscillations in Parkinson’s disease (PD) are related to decreased levels of dopamine and have been proposed as biomarkers to adapt and optimize therapeutic interven

Previous studies in developing Xenopus and zebrafish reported that the phosphate transporter slc20a1a is expressed in pronephric kidneys. The recent identification of SLC20A1 as a monoallelic candidate gene for cloacal exstrophy further suggests its involvement in the urinary tract and urorectal development. However, little is known of the functional role of SLC20A1 in urinary tract development. H

Animal tissue requires low-oxygen conditions for its maintenance. The need for low-oxygen conditions contrasts with the idea of an evolutionary leap in animal diversity as a result of expanding oxic conditions. To accommodate tissue renewal at oxic conditions, however, vertebrate animals and vascular plants demonstrate abilities to access hypoxia. Here, I argue that multicellular organisms sustain