Sarcomas represent a broad and heterogenous group of rare tumors. For some subtypes, there arepathognomonic genetic alterations available, while for others such alterations remain to be identified.Especially in entities that harbor large numbers of complex genetic changes, much still remains to beunderstood. One such entity is osteosarcoma, the most common primary bone tumor. Although primarilyaff

We regard the classic Thue–Morse diffraction measure as an equilibrium measure for a potential function with a logarithmic singularity over the doubling map. Our focus is on unusually fast scaling of the Birkhoff sums (superlinear) and of the local measure decay (superpolynomial). For several scaling functions, we show that points with this behavior are abundant in the sense of full Hausdorff dime

Silica has rarely been used as a seed particle material in acoustic trapping of nanoparticles. Here we use fluorescent nanoparticles, which are frequently used as a model system, to demonstrate that throughput and nanoparticle trapping efficiency can be improved by using silica seed particles as opposed to traditionally used polystyrene seed particles. The 10 times larger dipole scattering coeffic

This study aims to investigate the feasibility of enhancing the charge collection efficiency (CCE) of a transmission chamber by reconfiguring its design and operation. The goal was to extend the range of dose-per-pulse (DPP) values with no or minimal recombination effects up to the ultra-high dose rate (UHDR) regime. The response of two transmission chambers, with electrode distance of 1 mm and 0.

The complement system plays a central role in the pathogenesis of Systemic Lupus Erythematosus (SLE), but most studies have focused on the classical pathway. Ficolin-3 is the main initiator of the lectin pathway of complement in humans, but its role in systemic autoimmune disease has not been conclusively determined. Here, we combined biochemical and genetic approaches to assess the contribution o

BACKGROUND: Little is known about risks of hypertensive disorders of pregnancy in both first-and second-generation immigrant women in Europe and other Western countries; such knowledge may help elucidate the influence of genetic versus social factors on such risks. We aimed to study both first-and second-generation immigrant women for the presence of all types of hypertension (preexisting hyperten

Oat (Avena sativa) is a cereal grain rich in fibers, proteins, vitamins and minerals. Oats have been linked to several health benefits, such as lowering blood cholesterol levels, counteracting cardiovascular disease and regulating blood sugar levels. This study aimed to characterize two new oat lines with high β-glucan content emanating from ethyl methyl sulphonate mutagenesis on the Lantmännen el

We present the results on the relativistic six-pion scattering amplitude at low energy, calculated at O(p4) within the framework of the massive O(N) nonlinear sigma model extended to the next-to-leading order in the chiral counting. For N = 3, this approach corresponds to the two(quark)-flavor Chiral Perturbation Theory. We also present the expressions for the pion mass, pion decay constant and th

A prerequisite to applying 10Be in natural archives for solar and geomagnetic reconstructions is to know how 10Be deposition reflects atmospheric production changes. However, this relationship remains debated. To address this, we use two state-of-the-art global models GEOS-Chem and ECHAM6.3-HAM2.3 with the latest beryllium production model. During solar modulation, both models suggest that 10Be de

Background and Clonal haematopoiesis of indeterminate potential (CHIP), the age-related expansion of blood cells with preleukemic mutaAims tions, is associated with atherosclerotic cardiovascular disease and heart failure. This study aimed to test the association of CHIP with new-onset arrhythmias.Methods UK Biobank participants without prevalent arrhythmias were included. Co-primary study outcome

Archaeooides originally refers to a group of early Cambrian globular microfossils with regularly arranged nodular surface ornaments, and of a diameter ranging from less than 400 μm to more than 2 mm. The traditional taxonomy assigns all Archaeooides-like microfossils to a single morphotaxon, Archaeooides granulatus, irrespective of their differences in size and surface ornamentation. Archaeooides

Gamma-ray bursts (GRBs), due to their high luminosities, are detected up to a redshift of 10, and thus have the potential to be vital cosmological probes of early processes in the Universe. Fulfilling this potential requires a large sample of GRBs with known redshifts, but due to observational limitations, only 11% have known redshifts (z). There have been numerous attempts to estimate redshifts v

Crop models are often used to project future crop yield under climate and global change and typically show a broad range of outcomes. To understand differences in modeled responses, we analyzed modeled crop yield response types using impact response surfaces along four drivers of crop yield: carbon dioxide (C), temperature (T), water (W), and nitrogen (N). Crop yield response types help to underst

North - South collaboration between scientists and collaborators is increasingly prominent and promoted in research. This study examines power dynamics within a North-South research collaboration project conducted between institutions in Tanzania and Germany. The research design is guided by postcolonial considerations of knowledge production and seeks to amplify underrepresented voices from the S

Understanding the evolution of evolvability—the evolutionary potential of populations—is key to predicting adaptation to novel environments. Despite growing evidence that evolvability structures adaptation, it remains unclear how adaptation to novel environments in turn influences evolvability. Here we address the interplay between adaptation and evolvability in the peacock fly Tephritis conura, w

In Mantle Cell Lymphoma (MCL), the role of macrophages within the tumour microenvironment (TME) has recently gained attention due to their impact on prognosis and response to therapy. Despite their low absolute number in MCL tumour tissue, recent findings reveal an association between the levels of macrophages and prognosis, consistent with trends observed in other lymphoma subtypes. M2-like macro

This open access book tells stories of conviviality, solidarity, and everyday management of conflicts and tensions, by building on original, long-term ethnographic research (fourteen months in 2009-2010, followed by fieldwork trips until now) on Burgaz, an island home to more than twenty ethnic and religious groups from different socio-economic backgrounds. The island provides an excellent case st

PURPOSE: The gold standard for skin cancer diagnosis is surgical excisional biopsy and histopathological examination. Several non-invasive diagnostic techniques exist, although they have not yet translated into clinical use. This is a proof-of-concept study to assess the possibility of imaging an angiosarcoma in the periocular area.METHODS: We use laser speckle, hyperspectral, and photoacoustic im