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The cyanobacterial neurotoxin β-N-methylamino-L-alanine prevents addition of heparan sulfate to glypican-1 and increases processing of amyloid precursor protein in dividing neuronal cells

The neurotoxin β-N-methylamino-L-alanine replaces L-serine in proteins and produces Alzheimer-like pathology. In proteoglycans, e.g. glypican-1, this should preclude substitution with heparan sulfate chains. Reduced release of heparan sulfate should increase β-secretase activity and processing of amyloid precursor protein. Cultured cells were treated with β-N-methylamino-L-alanine during the growt

FibSim, a web application to refine fibrillar macromolecular models : Masters thesis in Bioinformatics

Fibrillar macromolecules are long, linear structures that have helical symmetry. A technique called X-ray fiber diffraction (XRFD) is often used to help solve the three-dimensional structure of fibrillar macromolecules. Models of fibrillar structure, built de novo, using homologs or using experimental data derived from other methods should be compared to this experimental XRFD data to test and ref

Plant type II NAD(P)H dehydrogenases : Structure, regulation and evolution of NDB proteins

In living organisms, respiration is a biological process degrading different carbon substrates, consuming O2, and releasing the carbon as CO2. Plants have several alternative enzymes that are involved in the respiratory processes, as compared to animals. These alternative respiratory enzymes allow electrons to be transferred to oxygen in the mitochondrial inner membrane, but bypassing ATP synthesiIn living organisms, respiration is a biological process degrading different carbon substrates, consuming O2, and releasing the carbon as CO2. Plants have several alternative enzymes that are involved in the respiratory processes, as compared to animals. These alternative respiratory enzymes allow electrons to be transferred to oxygen in the mitochondrial inner membrane, but bypassing ATP synthesi

Where and how do you buy medicines? A social and cultural study of attitudes towards buying medicines online and abroad among Swedish public

We start our presentation with a brief overview of the literature written about SF medical products in the social and cultural sciences. In September 2015, we broadly reviewed literature about the phenomenon of SF medical products, and identified research gaps regarding social, cultural and ethical aspects. Studies, presented below, are two pilot studies aimed to fill some of the gaps. In May 2018

Chiral perturbation theory in the meson sector

The present status of Chiral Perturbation Theory in the meson sector is discussed concentrating on recent developments. This write-up contains short discussions on a listing of a few historical papers, the principles behind ChPT, two-flavour ChPT including some comments about the Pion polarizability, three-flavour ChPT with a discussion of the recently found relations as tests of ChPT and prelimin

Baryon weak decays

A short overview of baryon weak decays and our present theoretical understanding is given. The successes and shortcomings of the various approaches are compared.

Chiral Lagrangians and Nambu-Jona-Lasinio like models

We discuss the low-energy analysis of models involving quarks and four-fermion couplings. The relation with QCD and with other models of mesons and meson plus quarks at low energies is discussed. A short description of how the heat-kernel expansion can be used to get regularization independent information, is given. The anomaly within this class of models and a physical prescription to obtain the

The anomalous sector of the strong interaction effective lagrangian

The effective action in the abnormal intrinsic parity sector is derived to next-to-leading order in the chiral perturbation theory expansion in the chiral limit under the assumption that chiral symmetry breaking is well described by the addition of a constituent quark mass term to the QCD action. The result is combined with the loop calculation done previously for the case of pseudoscalar decays i

Violations of Dashen's theorem

The electromagnetic contribution to the K+-K0 mass difference is calculated in the 1 Nc approach including the SU(3) breaking contributions due to a non-zero strange quark mass. The short-distance contribution can be unambiguously determined in terms of the known parameters of the next-to-leading order chiral Lagrangian. The long distance part is estimated using the 1 Nc approach by Bardeen et al.

Kℓ4 decays and the low-energy expansion

Tha amplitudes for the Kℓ4 decays are calculated to next-to-leading order in Chiral Perturbation Theory. These are then compared with the available experimental results on these decays. The values of the parameters L1, 2, 3 previously determined from ππ scattering are compared with those obtained here. A short overview of the determination of the parameters of Chiral Perturbation Theory is include

On the validity of chiral perturbation theory for the ΔI= 1 2 rule

The chiral perturbation theory relations of 〈ππ|O|K〉 to 〈π|O|K〉 and 〈o|O|K〉 needed for establishing the ΔI= 1 2 rule in hadronic weak decays via lattice calculations are examined beyond leading order and the domain of validity for this relation is established.

The ΔI = 1/2 rule in the chiral limit

We discuss the matching between long-distance and short-distance at next-to-leading in 1/Nc and show how the scheme-dependence from the two-loop renormalization group running can be treated. We then use this method to study the three O(p2) terms contributing to non-leptonic kaon decays, namely the usual octet and 27-plet derivative terms as well as the weak mass term using the Extended Nambu Jona-

Large extra dimensions in rare decays

The prospect of experimental verification of the large extra dimension scenario in rare decays is discussed. The case of J/ψ and γ to photon + missing energy is calculated in detail, and it is shown that the limit on the compactification scale MS lies at present in the ten GeV range. In contrast to the quarkonium systems, signals in Kaon and Pion decays will be small.