Cerebrospinal fluid (CSF) p-tau181 (tau phosphorylated at threonine 181) is an established biomarker of Alzheimer’s disease (AD), reflecting abnormal tau metabolism in the brain. Here we investigate the performance of CSF p-tau217 as a biomarker of AD in comparison to p-tau181. In the Swedish BioFINDER cohort (n = 194), p-tau217 shows stronger correlations with the tau positron emission tomography

The anthropological sciences have long been interested in how hunter-gatherers perceive and interact with their spatial environment. The spatially flexible and dynamic modes of subsistence and residence typical of many hunter-gatherer communities have been considered to be key factors in the social organisation and ideological framing of such communities. However, close attention to spatial repres

The response of evapotranspiration (ET) to warming is of critical importance to the water and carbon cycle of the boreal biome, a mosaic of land cover types dominated by forests and peatlands. The effect of warming-induced vapour pressure deficit (VPD) increases on boreal ET remains poorly understood because peatlands are not specifically represented as plant functional types in Earth system model

Patients with diffuse large B-cell lymphoma (DLBCL) who fail to complete planned treatment with R-CHOP due to toxicity are sparsely described. We investigated the extent of failure to complete treatment (six cycles or more, or three cycles + RT for patients with stage I disease) with R-CHOP for reasons unrelated to non-response, the determinants of such failure and the outcome among these patients

Instruments play an essential role in creating research data. Given the importance of instruments and associated metadata to the assessment of data quality and data reuse, globally unique, persistent and resolvable identification of instruments is crucial. The Research Data Alliance Working Group Persistent Identification of Instruments (PIDINST) developed a community-driven solution for persisten

This paper describes precision measurements of the transverse momentum pTℓℓ (ℓ= e, μ) and of the angular variable ϕη∗ distributions of Drell–Yan lepton pairs in a mass range of 66–116 GeV. The analysis uses data from 36.1 fb- 1 of proton–proton collisions at a centre-of-mass energy of s=13TeV collected by the ATLAS experiment at the LHC in 2015 and 2016. Measurements in electron-pair and muon-pair

Uncertainty analysis is important for wastewater treatment plant (WWTP) model applications. An important aspect of uncertainty analysis is the identification and proper quantification of sources of uncertainty. In this contribution, a methodology to identify an ensemble of behavioural model representations (combinations of input data, model structure and parameter values) is presented and evaluate

Purpose: To identify predictors of complete miscarriage after expectant management or misoprostol treatment of non-viable early pregnancy in women with vaginal bleeding. Methods: This was a planned secondary analysis of data from a published randomized controlled trial comparing expectant management with vaginal single dose of 800 µg misoprostol treatment of women with embryonic or anembryonic mis

New physics opportunities are opening up by the Advanced Gamma Tracking Array, AGATA, as it evolves to the full 4π instrument. AGATA is a high-resolution γ-ray spectrometer, solely built from highly segmented high-purity Ge detectors, capable of measuring γ rays from a few tens of keV to beyond 10 MeV, with unprecedented efficiency, excellent position resolution for individual γ-ray interactions,

Stimuli-responsive microgels have attracted much interest for their use as vehicles for drug delivery or as the building blocks of adaptive materials. Ionic microgel particles, including popular poly(NIPAM-co-acrylic acid), show strong mechanical responsiveness to many external stimuli, including changes in ionic strength or acidity. In this work, we demonstrate that combining multiple ionic stimu

The 2-deoxy (7), 6-O-methyl (15), 6-deoxy (22), and 6-deoxy-6-fluoro (31) derivatives of methyl β-d-galabioside (1) have been synthesised. Thus, 7 was prepared by xanthate reduction using tributyltin hydride, whereas 22 was obtained by catalytic hydrogenation of a 6-deoxy-6-iodogalabioside. Regioselective mono-fluorination of methyl 2,3-di-O-benzoyl-β-d-galactopyranoside with Et2NSF3 and subsequen

In this study, the authors develop knowledge and insights on how the perception of interestingness influences the structure and focus of conversations in entrepreneurial education (EE) research. In particular, the authors elaborate on what is perceived as interesting among different subgroups of EE researchers, and not least, how EE researchers can identify and engage in scholarly conversation wit

Ring signatures enable a signer to sign a message on behalf of a group anonymously, without revealing her identity. Similarly, threshold ring signatures allow several signers to sign the same message on behalf of a group; while the combined signature reveals that some threshold t of the group members signed the message, it does not leak anything else about the signers’ identities. Anonymity is a c

Plasma assisted combustion has been proposed as an efficient technique to enhance combustion, especially under the extreme conditions. For shedding light on the interactions between plasma and turbulent flame at extended conditions, a burner design with integrated electrodes was used to couple a non-thermal gliding arc (GA) discharge to a turbulent flame. The morphology and dynamic behaviors of th

In most control schemes it is advantageous to introduce integrators to eliminate off-set due to load disturbances. It is, however, also important to introduce nonlinearities, for instance due to limitations in actuators. The interaction between the integrator and the nonlinearities will cause problems with reset windup. Ways to handle anti-reset windup for different controller configurations are d

This paper discusses some problems that can arise in distributed real-time control systems, for instance, sampling- interval jitter, timeout, and asynchronous loops.

Freshwater ecosystems are under multiple threats in modern times such as water extraction for human consumption, industries and agricultural activities, water contamination and habitat destruction for example. At the same time the biodiversity of these ecosystems are often poorly studied, especially in arid countries such as Iran. In this work, we study one of the ecologically important members of