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Do GSTM1 and GSTT1 polymorphisms influence the risk of developing mitochondrial diseases in a Tunisian population?

Mitochondria play an essential role to supply the cell with metabolic energy in the form of adenosine triphosphate (ATP) through oxidative phosphorylation (OXPHOS). As a consequence, they are also the primary source of cellular reactive oxygen species (ROS) which can cause oxidative damage of individual respiratory chain complexes. Indeed, affected OXPHOS subunits result in decreases in ATP produc

Bringing Environmentalism Home: Children’s Influence on Family Consumption in the Nordic Countries and Beyond

This article discusses children as contributors to sustainable ecological development. The aim of the article is to develop a framework for researching two questions: What are the prerequisites for children to become responsible environmentalists? What actual and potential influence do children have on their family’s consumption? Three theoretical perspectives are elaborated in relation to relevan

Active-site plasticity revealed in the asymmetric dimer of AnPrx6 the 1-Cys peroxiredoxin and molecular chaperone from Anabaena sp. PCC 7120

Peroxiredoxins (Prxs) are vital regulators of intracellular reactive oxygen species levels in all living organisms. Their activity depends on one or two catalytically active cysteine residues, the peroxidatic Cys (CP) and, if present, the resolving Cys (CR). A detailed catalytic cycle has been derived for typical 2-Cys Prxs, however, little is known about the catalytic cycle of 1-Cys Prxs. We have

Determination of the strong coupling constant αs from transverse energy–energy correlations in multijet events at √s=8TeV using the ATLAS detector

Measurements of transverse energy–energy correlations and their associated asymmetries in multi-jet events using the ATLAS detector at the LHC are presented. The data used correspond to s=8TeV proton–proton collisions with an integrated luminosity of 20.2fb-1. The results are presented in bins of the scalar sum of the transverse momenta of the two leading jets, unfolded to the particle level and c

Air‐sea gas transfer in high Arctic fjords

In Arctic fjords and high‐latitude seas, strong surface cooling dominates during a large part of the year, generating water‐side convection (w* w) and enhanced turbulence in the water. These regions are key areas for the global carbon cycle; thus, a correct description of their air‐sea gas exchange is crucial. CO2 data were measured via the eddy covariance technique in marine Arctic conditions and

Individuals’ experiences with Brief Admission during the implementation of the Brief Admission Skåne RCT, a qualitative study

Background: Brief admission (BA) is an adjunctive treatment option for individuals with self-harming behavior, having traits of borderline personality disorder (BPD). It is offered alongside outpatient psychotherapy for the purpose of strengthening autonomy, self-reflection and self-care and to increase the likelihood of being able to stay in therapy by avoiding lengthy inpatient hospitalizations.

Insensitivity to atorvastatin is associated with increased accumulation of intracellular lipid droplets and fatty acid metabolism in breast cancer cells

Apart from the relevant lipid-lowering effects, statins have demonstrated significant, although heterogeneous, anti-tumor activities in preventing breast cancer (BC) progression. To characterize the critical pathways behind the diverse responses to therapy, we investigated statin-induced changes in regulation of lipid metabolism and abundance of neutral lipid-containing cytoplasmic lipid droplets

English in Primary Education in Sweden and Vietnam : Teaching practices, learner outcomes and out-of-school exposure

This thesis investigates the interaction between teaching and learning of English in young learners in Sweden and in Vietnam. It thus brings together two perspectives – teaching and learning – that are seldom compared between cultural contexts. The main focus of the study is to examine procedural and declarative knowledge of English grammar. A number of Grade 5 English lessons in primary school cl

Samma ojämlikhet som idag. : Kullabygden under järnåldern

Kullabygden I nordvästra Skåne är ett mindre exploaterat landskap med några få arkeologiska undersökningar i förhållande till andra delar i västra och södra Skåne. Järnåldern i området återspeglas bara av ett litet antal arkeologiska fynd, fornlämningar och ortnamn. De fragmentariska arkeologiska fynden är alla mycket exklusiva. Objekten visar tydligt att rika familjer bebodde området (de landlösa

Rotor-stator mixers : From batch to continuous mode of operation-A review

Although continuous production processes are often desired, many processing industries still work in batch mode due to technical limitations. Transitioning to continuous production requires an in-depth understanding of how each unit operation is affected by the shift. This contribution reviews the scientific understanding of similarities and differences between emulsification in turbulent rotor-st

Clinicians’ use of breast cancer risk assessment tools according to their perceived importance of breast cancer risk factors : an international survey

The BOADICEA breast cancer (BC) risk assessment model and its associated Web Application v3 (BWA) tool are being extended to incorporate additional genetic and non-genetic BC risk factors. From an online survey through the BOADICEA website and UK, Dutch, French and Swedish national genetic societies, we explored the relationships between the usage frequencies of the BWA and six other common BC ris

Tricorder: Building a Program Analysis Ecosystem

Static analysis tools help developers find bugs, improve code readability, and ensure consistent style across a project. However, these tools can be difficult to smoothly integrate with each other and into the developer workflow, particularly when scaling to large codebases. We present Tricorder, a program analysis platform aimed at building a data-driven ecosystem around program analysis. We pres

Zero-crossing statistics for non-Markovian time series

In applications spanning from image analysis and speech recognition to energy dissipation in turbulence and time-to failure of fatigued materials, researchers and engineers want to calculate how often a stochastic observable crosses a specific level, such as zero. At first glance this problem looks simple, but it is in fact theoretically very challenging, and therefore few exact results exist. One

Tacrolimus and Mycophenolate Mofetil as Second-Line Therapies for Pediatric Patients with Autoimmune Hepatitis

Background: We studied the efficacy and safety of mycophenolate mofetil (MMF) and tacrolimus as second-line therapy in pediatric patients with autoimmune hepatitis (AIH) who were intolerant or non-responders to standard therapy (corticosteroid and azathioprine). Patients and Methods: We performed a retrospective study of data from 13 centers in Europe, USA, and Canada. Thirty-eight patients (< 18

Dynamic interaction of local and transhemispheric networks is necessary for progressive intensification of hippocampal seizures

The detailed mechanisms of progressive intensification of seizures often occurring in epilepsy are not well understood. Animal models of kindling, with progressive intensification of stimulation-induced seizures, have been previously used to investigate alterations in neuronal networks, but has been obscured by limited recording capabilities during electrical stimulations. Remote networks in kindl

A review of the use of organic Rankine cycle power systems for maritime applications

Diesel engines are by far the most common means of propulsion aboard ships. It is estimated that around half of their fuel energy consumption is dissipated as low-grade heat. The organic Rankine cycle technology is a well-established solution for the energy conversion of thermal power from biomass combustion, geothermal reservoirs, and waste heat from industrial processes. However, its economic fe