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Transforming growth factor-β2 is associated with atherosclerotic plaque stability and lower risk for cardiovascular events
Aims: Transforming growth factor-beta (TGF-β) exists in three isoforms TGF-β1, -β2, and -β3. TGF-β1 has been suggested to be important for maintaining plaque stability, yet the role of TGF-β2 and -β3 in atherosclerosis remains to be investigated. This study explores the association of the three isoforms of TGF-β with plaque stability in the human atherosclerotic disease. Methods and results: TGF-β
Decision making among residents in training of obstetrics and gynecology: A qualitative exploration in Pakistani context
Medical decision-making is critical and the decisions are made under uncertain, complex, and dynamic conditions. In this regard, practitioners’ experiences and perceptions may provide a bottom-up knowledge of the issues, as well as a corresponding support system that assists them in learning to make decisions in critical situations. The current study aimed to examine these experiences in the Pakis
Factors associated to a low level of physical activity after out-of- hospital cardiac arrest: Results from the Targeted Hypothermia versus Targeted Normothermia after Out-of-Hospital Cardiac Arrest (TTM2) trial
Development of an instrument for self-reported cognitive function in cardiac arrest survivors: report from an ongoing study
Data politics in the built environment
Buildings and cities are increasingly being reconfigured and re-imagined by flows of data. Smart homes and cities, digitally networked infrastructure services, shared mobility programmes and autonomous vehicles, surveillance and security systems, and urban control centres are a few of the many examples of how data are emerging as an influential driver of urban development processes. The aim of thi
Dietary pesticide exposure and non-communicable diseases and mortality: a systematic review of prospective studies among adults
BackgroundResearch on the effect of pesticide exposure on health has been largely focused on occupational settings. Few reviews have synthesized the associations between dietary pesticide exposure and health outcomes in non-occupationally exposed adults.ObjectiveWe aim to summarize the evidence regarding dietary pesticide exposure and non-communicable diseases (NCD) in adults, using a systematic r
AI Risk Score on Screening Mammograms Preceding Breast Cancer Diagnosis
Background Few studies have evaluated the role of artificial intelligence (AI) in prior screening mammography. Purpose To examine AI risk scores assigned to screening mammography in women who were later diagnosed with breast cancer. Materials and Methods Image data and screening information of examinations performed from January 2004 to December 2019 as part of BreastScreen Norway were used in thi
Exploring the challenges and facilitators that impact the experiences of being an older female worker in the European labour market: Findings from a rapid review of literature
Older women make a significant contribution to the labour market yet still experiencenegative workplace impacts. We undertook a rapid review of literature to assess theexperiences of older female workers in the European labour market with the aim toidentify current research gaps. We discuss how current data and future research couldbe utilized to improve the working lives of older women in Europe.
Plötsligt händer det! Om nyfikenhet och lyckträffar på fältet.
Konspirationsteorier — ett politiskt dilemma
Identifying actionable druggable targets for breast cancer : Mendelian randomization and population-based analyses
Background: Drug repurposing provides a cost-effective approach to address the need for breast cancer prevention and therapeutics. We aimed to identify actionable druggable targets using Mendelian randomization (MR) and then validate the candidate drugs using population-based analyses. Methods: We identified genetic instruments for 1406 actionable targets of approved non-oncological drugs based on
Priorities in Cardio-Oncology Basic and Translational Science : GCOS 2023 Symposium Proceedings: JACC: CardioOncology State-of-the-Art Review
Despite improvements in cancer survival, cancer therapy–related cardiovascular toxicity has risen to become a prominent clinical challenge. This has led to the growth of the burgeoning field of cardio-oncology, which aims to advance the cardiovascular health of cancer patients and survivors, through actionable and translatable science. In these Global Cardio-Oncology Symposium 2023 scientific symp
Signaling to the immature brain - Choroid plexus, insulin-like growth factor 1 and extracellular vesicles
I Sverige överlever idag uppemot 80% av de barnen som är födda extremt för tidigt (födda innan graviditetsvecka 28). Dock medföljer en hög sjuklighet, där uppemot 20% av barnen utvecklar olika sjukdomstillstånd såsom blödning i hjärnas hålrum, även kallat intra-ventrikulär hjärnblödning (IVH). Dessutom löper de extremt för tidigt födda barnen en ökad risk att utveckla en intellektuell och neurologExtremely preterm infants (i.e., born below 28 gestational weeks), are at high risk of developing brain morbidities including intraventricular hemorrhage (IVH) and neurodevelopmental impairment. Despite over 50 years of research, there is currently no effective therapy available for preventing IVH. Insulin-like growth factor 1 (IGF-1) plays a pivotal role in perinatal development. Extremely preter
Nödbistånd till boende : Hantering av "strukturellt hemlösa" i Malmö
Could Be it’s Grammaticalization : Usage Patterns of the Epistemic Phrases (it) Could/Might Be
Starting from the assumption that grammaticalization is rooted in situated language use, the present study tests the connection between functional reanalysis and formal reduction with a synchronic approach. It investigates a case of potential (but not actuated) grammaticalization in Present-Day English, the use of epistemic phrases of the type it could/might be (that), which can serve an adverbial
Could be, might be, maybe : Mechanisms of grammaticalization in synchronic use and perception
In grammaticalization, functional reanalysis and formal reduction are often regarded as elements of a unified diachronic process, though rooted in general communicative and cognitive preferences. The present study tests these claims in synchronic language use by investigating potential cases of grammaticalization. Epistemic phrases of the type (it) could/might be (that) in English are potential ca
Proton halo effects in the 8B+64Zn collision around the Coulomb barrier
The 8B+64Zn reaction at 38.5 MeV has been studied at HIE-ISOLDE CERN to investigate proton halo effect on the reaction dynamics. For the first time it was used the only existing post-accelerated 8B beam. The measured elastic scattering angular distribution showed a small suppression of the Coulomb-nuclear interference peak, opposite to what observed for the one-neutron halo nucleus 11Be on the sam
David Correia Saavedra : Measurements of grammaticalization: Developing a quantitative index for the study of grammatical change
Communicative efficiency and the Principle of No Synonymy : predictability effects and the variation of want to and wanna
There is ample psycholinguistic evidence that speakers behave efficiently, using shorter and less effortful constructions when the meaning is more predictable, and longer and more effortful ones when it is less predictable. However, the Principle of No Synonymy requires that all formally distinct variants should also be functionally different. The question is how much two related constructions sho