The formation of amyloid fibrils is a general class of protein self-assembly behaviour, which is associated with both functional biology and the development of a number of disorders, such as Alzheimer and Parkinson diseases. In this Review, we discuss how general physical concepts from the study of phase transitions can be used to illuminate the fundamental mechanisms of amyloid self-assembly. We

The volume provides a first-ever comprehensive account of the concept and the role of the family in EU law. It explores the family in EU law from four different angles. The first part of the book considers the philosophical and theoretical foundations of the family in the law in general, including the definition of the family under EU law. The second part provides an overview of the rights conferr

This letter presents the development of novel iterated filters and smoothers that only require specification of the conditional moments of the dynamic and measurement models. This leads to generalizations of the iterated extended Kalman filter, the iterated extended Kalman smoother, the iterated posterior linearization filter, and the iterated posterior linearization smoother. The connections to t

This paper is concerned with tracking of reference vectors in the continuous-discrete-time setting. For this end, an Itô stochastic differential equation, using the gyroscope as input, is formulated that explicitly accounts for the geometry of the problem. The filtering problem is solved by restricting the prediction and filtering distributions to the von Mises-Fisher class, resulting in ordinary

Vi befinner oss i en formativ period gällande AI-reglering där de beslut som tas kommer att ha stor påverkan för en väsentlig tid framåt, globalt, i Europa såväl som i Sverige. Syftet med den här rapporten är att analysera processen med framtagandet av den europeiska AI-förordningen, dvs. placera in AI-regleringsaspekter i ett bredare perspektiv. Det görs genom att belysa rättsliga utmaningar kopp

Objective: Patient-specific virtual reality (VR) simulation of cochlear implant (CI) surgery potentially enables preoperative rehearsal and planning. We aim to gather supporting validity evidence for patient-specific simulation through the analysis of virtual performance and comparison with postoperative imaging. Methods: Prospective, multi-institutional study. Pre- and postoperative cone-beam CT

Agricultural extension, or advisory services, have a key role to play in supporting farmers’ learning and adoption of new practices and technologies. This paper analyses gaps and needs which require addressing in order for extension systems to more effectively contribute to the upscaling of ecological intensification approaches in East African smallholder agriculture. Our starting point is the pus

COVID-19 was first identified in Wuhan City in December 2019 and spread throughout Hubei Province and other parts of China. After causing significant morbidity and mortality in China, by February 2020, it had spread to numerous other countries, infecting millions of people and causing a large number of deaths across the world. The COVID-19 pandemic put a burden on almost all areas of the world inc

In this paper, we propose a new framework for solving state estimation problems with an additional sparsity-promoting $L-1$-regularizer term. We first formulate such problems as minimization of the sum of linear or nonlinear quadratic error terms and an extra regularizer, and then present novel algorithms which solve the linear and nonlinear cases. The methods are based on a combination of the ite

In this work, we consider the problem of estimating the directions of arrival of far-field sources impinging on a sensor array using a computationally efficient approach. A novel adaptive grid selection technique is employed to reduce the dimensionality of the used dictionary matrix. The method further makes use of a SPICE-inspired dictionary to adaptively select an appropriate regularization para

Aim: To determine the prevalence of neurobehavioral symptoms at 6.5 years in children born extremely preterm (EPT,

This thesis emanates from the discursive gap between a medical discourse andexperience-driven knowledges in mental health aspects of hormonal contraceptives.The tensions and fractures between a medical discourse focusing on contraceptiveeffectiveness and largely refuting any significant adverse outcomes, and experiencebasednarratives of commonplace detrimental, or at least unwelcome and unpleasant

The aim of the study was to examine how counselors at the women's clinic relate to existential questions in the meeting with patients related to social work in a healthcare setting. The intention was to look closer at what challenges the staff faces, as well as what they find obstacles that stop or make it difficult to talk about existential issues. This was investigated through semi-structure

We report about the properties of the underlying event measured with ALICE at the LHC in pp and p–Pb collisions at sNN = 5.02 TeV. The event activity, quantified by charged-particle number and summed-p T densities, is measured as a function of the leading-particle transverse momentum (pTtrig) . These quantities are studied in three azimuthal-angle regions relative to the leading particle in the ev