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The activity of barley NADPH-dependent thioredoxin reductase C is independent of the oligomeric state of the protein: tetrameric structure determined by cryo-electron microscopy

Thioredoxin and thioredoxin reductase can regulate cell metabolism through redox regulation of disulfide bridges or through removal of H(2)O(2). These two enzymatic functions are combined in NADPH-dependent thioredoxin reductase C (NTRC), which contains an N-terminal thioredoxin reductase domain fused with a C-terminal thioredoxin domain. Rice NTRC exists in different oligomeric states, depending

The implementation of Innovation Metrics: A case study

The paper explores the implementation process of an innovation measuring system prototype to support a heavy machinery multinational company to secure their innovative capability. In general, companies recognize the importance of becoming innovative to become, or remain, competitive on a global market. The case company decided to pilot a metric system that corresponds to the crucial factors to sec

Biomarkers from bronchoalveolar lavage fluid in systemic sclerosis patients with interstitial lung disease relate to severity of lung fibrosis.

OBJECTIVES: Decision on treatment of systemic sclerosis (SSc) related interstitial lung disease (ILD) largely relies on the findings on high resolution computed tomography (HRCT) and there is a need for improvement in assessment of the fibrotic activity. The objectives of this study were to study biomarkers in bronchoalveolar lavage fluid (BALF) from SSc patients with ILD and to relate the finding

Synthesis, characterization, and reactivity studies of heterodinuclear complexes modeling active sites in purple Acid phospatases.

To model the heterodinuclear active sites in plant purple acid phosphatases, a mononuclear synthon, [Fe(III)(H(2)IPCPMP)(Cl(2))][PF(6)] (1), has been generated in situ from the ligand 2-(N-isopropyl-N-((2-pyridyl)methyl)aminomethyl)-6-(N-(carboxylmethyl)-N-((2-pyridyl)methyl)amino methyl)-4-methylphenol (IPCPMP) and used to synthesize heterodinuclear complexes of the formulas [Fe(III)M(II)(IPCPMP)

Energy and Mass Exchange and the Productivity of Main Siberian Ecosystems (from Eddy Covariance Measurements). 2. Carbon Exchange and Productivity

Direct measurements of CO2 fluxes by the eddy covariance method have demonstrated that the examined middle-taiga pine forest, raised bog, true steppe, and southern tundra along the Yenisei meridian (similar to 90 degrees E) are carbon sinks of different capacities according to annual output. The tundra acts as a carbon sink starting from June; forest and bog, from May; and steppe, from the end of

Managing differentiation of higher education system in Japan: connecting excellence and diversity

This article presents recent reform processes in Japanese higher education, concerning the tensions emerging within the system regarding 'excellence' and 'diversity'. The article particularly focuses on how Japanese universities have reacted to the recent 'competition' and 'differentiation' policy promoted by the government, drawing on recent survey results conducted with academic managers at Japa

Moraxella catarrhalis Evades Host Innate Immunity via Targeting Cartilage Oligomeric Matrix Protein.

Moraxella catarrhalis is a respiratory tract pathogen commonly causing otitis media in children and acute exacerbations in patients suffering from chronic obstructive pulmonary disease. Cartilage oligomeric matrix protein (COMP) functions as a structural component in cartilage, as well as a regulator of complement activity. Importantly, COMP is detected in resident macrophages and monocytes, alveo

Icatibant, a New Bradykinin-Receptor Antagonist, in Hereditary Angioedema

BACKGROUND Hereditary angioedema is characterized by recurrent attacks of angioedema of the skin, larynx, and gastrointestinal tract. Bradykinin is the key mediator of symptoms. Icatibant is a selective bradykinin B2 receptor antagonist. METHODS In two double-blind, randomized, multicenter trials, we evaluated the effect of icatibant in patients with hereditary angioedema presenting with cutaneous

Posttraumatic Stress Symptoms in Breast Cancer Patients: Temporal Evolution, Predictors, and Mediation

This study (N = 102 women) evaluated the time course of posttraumatic stress symptomatology (PTSS) at different stages of nonmetastastic cancer diagnosis and treatment: during treatment, at the end of treatment, and at a 6-12 months follow-up. We also assessed the contribution of demographic, trait, and state predictors to PTSS, and coping processes as proximal mediators of the relation between Ty

Comparison of quantitative dynamic susceptibility-contrast MRI perfusion estimates obtained using different contrast-agent administration schemes at 3T.

Absolute cerebral perfusion parameters were obtained by dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) carried out using different contrast-agent administration protocols. Sixteen healthy volunteers underwent three separate DSC-MRI examinations each, receiving single-dose (0.1mmol/kg b.w.) gadobutrol, double-dose gadobutrol and single-dose gadobenate-dimeglumine on different

Mesopredator release by an emergent superpredator: A natural experiment of predation in a three level guild

Background: Intraguild predation (IGP) is widespread but it is often neglected that guilds commonly include many layers of dominance within. This could obscure the effects of IGP making unclear whether the intermediate or the bottom mesopredator will bear higher costs from the emergence of a new top predator. Methodology/Principal Findings: In one of the most extensive datasets of avian IGP, we an

Role of wave velocity for encountered wave statistics

Encountering waves overtaking a ship sailing on the ocean may cause instability. Therefore it is of great importance to study the properties of such waves, for example slope, wavelength and amplitude. When making statistics on the properties of overtaking waves, only the waves that are faster than the ship will affect the resulting distribution. Thus the velocity of the individual waves plays an i

Risk of sick leave and disability pension in working-age women and men with knee osteoarthritis.

OBJECTIVES: To investigate sick leave and disability pension in working-age subjects with knee osteoarthritis (OA) compared with the general population. METHODS: Population-based cohort study: individual-level inpatient and outpatient Skåne Health Care Register data were linked with data from the Swedish Social Insurance Agency. In 2009 all working-age (16-64 years) Skåne County residents who i