Huntington's disease (HD) is a genetic neurodegenerative disorder. Since identification of the disease-causing gene in 1993, a number of genetically modified animal models of HD have been generated. The first transgenic mouse models, R6/1 and R6/2 lines, were established 8 years ago. The R6/2 mice have been the best characterized and the most widely used model to study pathogenesis of HD and thera

A chemiluminescent (CL) based micro-immuno supported liquid membrane assay (mu-ISLMA) has been developed that enables clean up, enrichment and detection of simazine in a single miniaturised cartridge system. The mu-ISLM cartridge contains a supported liquid membrane (SLM) sandwiched between a donor and an acceptor plate (channel volumes 1.65 mu L), the latter being covered by a thin layer of gold

The structures of the hydrated thallium(III) halide and pseudohalide complexes, [TlX(n)(OH2)(m)]((3-n)+), X = Cl, Br, CN, in aqueous solution have been studied by a combination of X-ray absorption fine structure spectroscopy (XAFS), large-angle X-ray scattering (LAXS), and vibrational spectroscopic (Raman and IR) techniques including far-infrared studies of aqueous solutions and some solid phases

OBJECTIVE—The goal of this study was to evaluate the performance of surrogate measures of insulin sensitivity and insulin secretion. RESEARCH DESIGN AND METHODS—The homeostasis model assessment (HOMA) of insulin resistance (IR) and the insulin sensitivity index (Si) from oral glucose tolerance test (OGTT) were compared with the M value from a hyperinsulinemic-euglycemic clamp in 467 subjects with

Submonolayer coverages of Au on Si(111), known as the 5 X 2, alpha- root3 X root3, beta- root3 X root3, 2root21 X 2root21, and 6 X 6 surfaces, have been investigated by low-energy electron diffraction and photoelectron spectroscopy. Three Si 2p surface components on the 5 X 2 surface, and four surface components on the alpha- root3 X root3, quenched beta- root3 X root3, and 6 X 6 surfaces have bee

MR spectroscopy was performed in three patients with brain abscesses. In two patients, MR spectroscopy revealed end-products of bacterial breakdown (acetate, succinate, amino acids, lactate) in the abscess cysts. In one of these, the spectrum was reversed to a single lactate peak after treatment. In the third patient, MR spectroscopy was performed only after treatment and showed a single nonspecif

Glucagon- like peptide-1 ( GLP-1) plays a significant role in glucose homeostasis through its incretin effect on insulin secretion. However, GLP-1 also exhibits extrapancreatic actions, and in particular its possible influences on insulin sensitivity are controversial. To study the dynamic action of GLP-1 on insulin sensitivity, we applied advanced statistical modeling methods to study glucose dis

In colostrum collected 0-80 h postpartum the contents of immunoglobulins (Igs), transforming growth factor beta-2 (TGF-beta2), insulin-like growth factor-1 (IGF-1) and growth hormone (GH) were analysed. Colostrum initially contained 90 mg mL(-1) IgG1, 2.8 mg mL(-1) IgG2, 1.6 mg mL(-1) IgA, 4.5 mg mL(-1) IgM, and these concentrations declined by 92%, 87%, 93% and 84%, respectively, in the samples c

The four-year visual outcome was retrospectively studied in patients with older-onset diabetes mellitus and diabetic retinopathy in need of laser treatment. Visual acuity in 53 patients examined by ophthalmologists who referred the patients for an evaluation of retinopathy before laser treatment, was compared to that of 47 patients examined by ophthalmologists who also performed the photocoagulati

This article aims to estimate the prevalence of SOX13 antibodies in Swedish patients with type 1 diabetes and healthy controls. The patients (n = 102; median age 35 years [range, 9-89]) were newly diagnosed with type 1 diabetes in a defined area in southern Sweden during 1995-1998. Islet cell antibodies (ICA) were analyzed with immunofluorescence, while glutamic acid decarboxylase antibodies (GADA

Monte Carlo programs, like the SIMIND program, have become increasingly used to simulate imaging systems like the scintillation camera and SPECT systems. Up to now, it has not been able to simulate a pinhole-imaging device with SIMIND. The aim of this work was to develop a routine for pinhole-imaging consisting of a knife-edge collimator and a conical shielding. The routine tracks the path of each

Gastric MUC5AC and MUC6 mucins were studied using polyclonal antibodies. Immunohistochemistry showed MUC5AC to originate from the surface epithelium, whereas MUC6 was produced by the glands. Mucins from the surface epithelium or glands of corpus and antrum were purified using CsCl/4M guanidinium chloride density-gradient centrifugation. MUC5AC appeared as two distinct populations at 1.4 and 1.3 g/

Resonance scattering of light as function of magnetic field has been used to investigate the hyperfine structure of the 4p2P3/2- and 5p2P3/2-terms in the potassiumI-spectrum, using a sample enriched in the K40-isotope. With increasing magnetic field strength a structure containing two characteristic signals for K40 was observed. Taking into account the small ratio of hyperfine structure splitting

As part of the restoration of biodiversity on former agricultural land there has been focused on methods to enhance the rate of transition from agricultural land towards natural grasslands or forest ecosystems. Management practices such as sowing seed mixtures and inoculating soil of later successional stages have been used. The aim of this study was to determine the effects of a managed plant com

Early diagnosis of atherosclerosis is essential as many of the risk factors are life-style dependent. We suggest a new method to measure minute roughness of the size of micrometers of the arterial wall. The method was evaluated using three silicone phantoms sized 13 fun, 23 itm and 33 pm, respectively. The mean of the measured heights of the phantoms were 8.1 mu m (SD 0.0), 23.3 mu m (SD 0.2) and

Between 1991 and 1994 the number of beds in the surgical clinic at a central hospital in Southern Sweden was cut back by almost 50%. To develop the nursing care and to control the effects of the budgetary cuts, an intervention, including nursing care development, of an organization that would secure continuity in the nurse-patient relationship, individually planned care and quality assurance for a