Abstract in Danish Infliximab er effektiv ved reumatoid artritis (RA), men behandlingssvigt er hyppige. Sera fra 106 RA-patienter monitoreredes med en radioimmunoassay (RIA) for funktionel infliximab og en RIA for anti-infliximab-antistof. S-infliximab varierede betydeligt, f.eks. 0-22 μg/ml forud for tredje infusion, og efter seks måneder var 44% antistofpositive. Lav S-infliximab var forbundet mRemicade/infliximab is effective in rheumatoid arthritis (RA), but response failure is frequent. Sera from 106 RA patients were monitored using an RIA for functional infliximab and an RIA for anti-infliximab antibody (Ab). S-infliximab varied considerably, e.g. 0-22 microg/ml before the 3rd infusion, and 44% were Ab-positive after 6 months. Low s-infliximab was associated with Ab development and l

In order to disentangle if and when resource supply and adult and young-of-the-year (0+) fish predation affect zooplankton dynamics during spring, we monitored zooplankton during three consecutive years in a lake in southern Sweden. We also experimentally assessed 0+ fish predation rates and estimated changes in predation rates of adult fish on zooplankton. Decline in abundances of large-sized zoo

Background: Mutations in the PRSS1 gene explain most occurrences of hereditary pancreatitis (HP) but many HP families have no PRSS1 mutation. Recently, an association between the mutation N34S in the pancreatic secretary trypsin inhibitor (SPINK1 or PSTI) gene and idiopathic chronic pancreatitis (ICP) was reported. It is unclear whether the N34S mutation is a cause of pancreatitis per se, whether

This thesis concerns numerical calculations of compressible separated flows, with and without shocks, around wing sections using Large Eddy Simulations (LES). The considered geometries are the NACA 0012 wing section and the ONERA AT15A wing section. Compressible separated flows around wing sections are of considerable interest, for engineering and scientific reasons, since they involve transition,

The article aims at pointing out the limitations of those archaeological approaches in the field of medieval studies that strictly follow the medieval social theory of the three and later four orders/estates. As an example of the possibilities offered by the use of an contextual approach in attempting to transcend the borders of the four-estate model, an analysis and interpretation of the pottery

Wound healing that precedes scar formation may be unbalanced under pathological conditions leading to structural changes of the tissue. At the moment, the mechanisms behind this unbalance are unclear. When these changes occur in internal organs such as the lung, they may result in organ dysfunction with fatal consequences for the patient. This phenomenon is defined as airway remodeling, and occurs

Popular Abstract in Swedish Ärftlig blindhet orsakas oftast av sjukdomar där näthinnans fotoreceptorer, som ombesörjer omvandlingen av ljus till elektriska impulser, degenererar. Det anses att denna celldödsprocess styrs av ett antal olika mekanismer och projektets mål är att försöka identifiera och karaktärisera dessa mekanismer. Retinitis Pigmentosa (RP) är en ärftlig sjukdom där en genetisk defRetinitis pigmentosa (RP) is an inherited disorder and the leading cause of visual impairment in the working age population. It is caused by a number of different genetic mutations, all of which cause the rod photoreceptors to degenerate. As the rods become few in numbers, the cones will also begin to die, resulting in total blindness. Since the genetic defects leading to RP are numerous, it would

A platform for rapid on-line protein digestion of protein mixtures for direct infusion to a mass spectrometer is presented. A mixture of protein A, staphylococcal enterotoxin B and cytochrome c was used as a model mixture injected on a gel filtration column and a trypsin reactor which were connected in series to a micro liquid chromatography (mu LC) system. The peptides in the column eluate were a

Rheumatoid arthritis (RA) is a multifactorial, polygenic autoimmune disease. For effective treatment and control of RA, understanding of disease pathways and identification of genes involved are essential. Animal models are efficient tools to identify such pathogenic mechanisms and genes underlying the disease process. In the present study, collagen antibody induced arthritis (CAIA), a mouse model

In analyses of strategy-proof voting, two results feature prominently: the dictatorial characterization contained in the Gibbard-Satterthwaite theorem and the voting by committees characterization in the Barbera-Sonnenschein-Zhou theorem. The two theorems are based on voting procedures defined on the domain of strict preferences. In the present study, we derive corresponding results for voting sch