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The size effect in shear strength of longitudinally reinforced beams is studied by means of a nonlinear fracture mechanics model. According to the actual theoretical study, structure size should be normalized to an intrinsic length parameter of the concrete. This length parameter is proportional to the fracture energy G//F of the concrete. It is found that the shear strength of a concrete beam may

The five different CP conserving amplitudes for the decays K --> 3pi are calculated using Chiral Perturbation Theory. The calculation is made to next-to-leading order and includes full isospin breaking. The squared amplitudes are compared with the corresponding ones in the isospin limit to estimate the size of the isospin breaking effects. In this paper we add the radiative corrections to the earl

Toll-like receptor-4 activation by lipopolysaccharide (LPS) induces the expression of interferon-P (IFN-beta) in a MyD88-independent manner. Here we report that mice devoid of the JAK protein tyrosine kinase family member, Tyk2, were resistant to shock induced by high doses of LPS. Basal and LPS-induced expression of IFN-beta and IFN-alpha4 mRNA in Tyk2-null macrophages were diminished. However, T

The modelling of premixed turbulent combustion has been studied. Premixed turbulent combustion occurs in a range of applications, such as gas turbines and spark-ignition engines. It is important that the modelling can capture the most relevant details of the combustion in order to minimize the emissions and secure the operability already in the design process of these devices. As the simulation of

Objectives To obtain reference data representative of normal findings at anal endosonography in pregnant and non-pregnant women. To determine intraobserver and interobserver agreement in the detection of endosonographic anal sphincter defects in asymptomatic women. Methods Twenty-five non-pregnant nulliparous women and 25 non-pregnant parous women (age range, 20-67 years) and 47 pregnant women (a

This article builds on the introduction to the concept of distributed economies (DE) by Johansson et al. [Johansson A, Kisch P, Mirata M. Distributed economies - a new engine for innovation. Journal of Cleaner Production, this issue] and takes the discussion further by reviewing examples of production systems that, due to certain characteristics, can be seen as illustrative DE elements. Through se

The mechanism, thermodynamics and kinetics of light-induced cyclic electron transfer have been studied in a model energy-transducing system consisting of solubilized Rhodobacter sphaeroides reaction center/light harvesting-1 complexes (so-called core complexes), horse heart cytochrome c and a ubiquinone-0/ubiquinol-0 pool. An analysis of the steady-state kinetics of cytochrome c reduction by ubiqu

The effect of hydrophilically modified polystyrene, poly(styrene-g-poly(ethylene oxide)), P(S-g-PEC), on the viscosity of ACT oil-continuous microemulsions has been investigated as a function of PS and PEO chain lengths and PEO chain density. A series of polymers, P (S-g-PEO) with PEO chain lengths of 23 or 9, and different graft densities were synthesized by living radical polymerization. Thus, a

Eleven adults spontaneously-hypertensive male rats (SHR) were studied 22 h or 7 days after a 2 h unilateral occlusion of the right middle cerebral artery (MCA). Another 11 SHR were studied after 24 h or 7 days of permanent MCA ligation. The brain infarcts were significantly larger (P < 0.05) after permanent occlusion than after a 2 h occlusion. More extensive and widespread vasogenic oedema, emana

Concentrations of plasma lipoproteins in 10 men who were habitual smokers were monitored for six weeks after they stopped smoking and related to changes in diet and body weight. The energy intake increased by 10% (p less than 0.05) owing to a higher consumption of carbohydrates and fat, and body weight increased by 2% (p less than 0.01). Plasma triglyceride, cholesterol, and low-density lipoprotei

Peroxidases, oxygenases and catalases have similar high-valent metal-ion intermediates in their respective reaction cycles. In this review, haem-based examples will be discussed. The intermediates of the haem-containing enzymes have been extensively studied for many years by different spectroscopic methods like UV-Vis, EPR (electron paramagnetic resonance), resonance Raman, Mossbauer and MCD (magn

Human L68Q cystatin C is one of the known human amyloidogenic proteins. In its native state it is a monomer with alpha/beta structure. Experimental evidence suggests that L68Q variant associates into dimeric intermediates and that the dimers subsequently self-assemble to form amyloid deposits and insoluble fibrils. Details of the pathway of L68Q mutant amyloid formation are unclear; however, diffe