In this thesis, acoustofluidics has been used to process blood samples as a sample preparation step prior to biomarker detection. This is often required as the large amount of blood cells otherwise can interfere with the detection method. Acoustofluidics means moving particles or cells with acoustic forces within microfluidic channels. Ultrasound is used to create a standing wave between the chann

The grounding objection to presentism rests on two premises: (i) every true proposition P has a truthmaker T, and (ii) some claims about the future and past are obviously true. However, if the future and past do not exist, there can be no truthmakers for future and past tensed expressions. Presentists tend not to challenge the premises of the objection. Instead they argue that the present contains

A new approach to characterise the evolution and coupling of deformation and fluid flow in geomaterials is presented. The method exploits some key features of neutrons, namely penetration of dense materials used for triaxial pressure cells, sensitivity to hydrogen and the possibility to distinguish hydrogen from its isotope deuterium (in normal water, H2O, and heavy water, D2O, respectively). Illu

Multiconfigurational methods are applied to study electronic properties and structural changes in the highly flexible metal-organic framework MIL53(Cr). Via calculated bending potentials of angles, that change the most during phase transition, it is verified that the high flexibility of this material is not a question about special electronic properties in the coordination chemistry, but about ove

The Arctic tundra plays an important role in the carbon cycle as it stores 50% of global soil organic carbon reservoirs. The processes (fluxes) regulating these stocks are predicted to change due to direct and indirect effects of climate change. Understanding the current and future carbon balance calls for a summary of the level of knowledge regarding chamber-derived carbon dioxide (CO2) flux stud

Deoxyadenosine kinase from Dictyostelium discoideum (DddAK) phosphorylates its natural substrate (2’-deoxyadenosine, dAdo) as well as the arabinosyladenine analogues vidarabine (araA) and fludarabine (F-araA) to their corresponding 5’-monophosphates. DddAK has been here immobilized by ionic interaction on an aminated epoxy-functionalized support (SepabeadsTM EC-EP), and cross-linked with oxidized

In this work, a carbon felt electrode (CFE) was modified with a multiwalled carbon nanotube-gold-platinum (MWCNT-Au-Pt) hybrid nanomaterial and integrated with an osmium redox polymer (OsRP, [Os(2, 2’-bipyridine)2(poly-vinylimidazole)10Cl]Cl) and Gluconobacter oxydans DSM 2343 (G. oxydans) cells. The developed electrode was used as the bioanode in a 5.0 mM K3Fe(CN)6mediator containing phosphate bu

Bärbara datorer och smarta telefoner har kommit att utmana arbetets traditionella gränser och bidragit till nya former att kombinera arbete med övrigt liv. När arbete sker på bekostnad av engagemang i den privata sfären, leder det ofta till upplevelser av stress och rollkon ikter, sk ”spillover”. ”Spillover” är en riskfaktor för hälsa och välbe nnande, men forskningen har ännu luckor för hur denna

For better or worse work plays a major role in both the psychological and thephysical well-being in peoples’ lives. Work can be a source of meaning, joy and self fulfilment, or a cause of distress and illness. This holds true even in wealthy parts ofthe world with a long tradition of research and governmental actions to achieve a goodworking environments. For example, in Sweden an average of 35 pe

Mitochondrial diabetes mellitus (MDM) presenting with a mitochondrial DNA 3243 (A-G) mutation is most frequently observed in patients with diabetes caused by a genetic defect. Clinical manifestations include short stature, the absence of obesity, young-onset, and the maternal inheritance of diabetes. MDM is strongly associated with neurosensory deafness, which is often overlooked during routine me

Accumulation of phosphatidylcholine hydroperoxide (PCOOH), a primary oxidation product of phosphatidylcholine, in blood plasma has been observed in various pathological conditions, including atherosclerosis. In this study, we investigated the use of liquid chromatography-tandem mass spectrometry (LC-MS/MS) to develop a method for accurate quantification of PCOOH (1-palmitoyl-2-hydroperoxyoctadecad

Aim: We investigated how dietary management affected body weight (BW) reduction and energy expenditure in obese and normal-weight type 2 diabetic patients. Methods: Type 2 diabetic patients who were hospitalized for diabetic control (93 men and 51 women) were checked for resting energy expenditure (REE). Subjects were divided into the two groups according to body mass index (BMI): obese (BMI ≥ 25)

Aims: The atherogenicity of chylomicron remnants has been discussed. We examined whether serum apoB48 level is associated with the presence of carotid plaque in type 2 diabetic patients. Method: Forty type 2 diabetic patients (21 males and 19 females, 52.8 ± 11.8 years old; mean ± S.D.) were divided into two groups by the presence or absence of carotid plaque. The diurnal change of serum apoB48 le

The Scandinavian heart transplant everolimus de novo study with early calcineurin inhibitors avoidance (SCHEDULE) trial was a 12 month, randomized, open-label, parallel-group trial that compared everolimus (EVR; n=56) to conventional CsA (n=59) immunosuppression. Previously, we reported that EVR outperformed CsA in improving renal function and coronary artery vasculopathy, despite a higher rejecti

We study how close-in systems such as those detected by Kepler are affected by the dynamics of bodies in the outer system. We consider two scenarios: outer systems of giant planets potentially unstable to planet-planet scattering and wide binaries that may be capable of driving Kozai or other secular variations of outer planets' eccentricities. Dynamical excitation of planets in the outer system r

Background: Working conditions substantially influence health, work ability and sick leave. Useful instruments to help clinicians pay attention to working conditions are lacking in primary care (PC). The aim of this study was to test the validity of a short "Blue flags" questionnaire, which focuses on work-related psychosocial risk factors and any potential need for contacts and/or actions at the