Background Preventive programs for individuals who have high lifetime risks of colorectal cancer may reduce disease morbidity and mortality. Thus, it is important to identify the factors that are associated with hereditary colorectal cancer and to monitor the effects of tailored surveillance. In particular, patients with Lynch syndrome, hereditary nonpolyposis colorectal cancer (HNPCC), have an in

Popular Abstract in Swedish Min forskning har syftat till att bota och förstå blodbristsjukdomen Diamond-Blackfan anemi (DBA). DBA är en sjukdom som upptäcks under första levnadsåret då barnet uppvisar symptom som trötthet och blekhet, p g a lågt hemoglobin blodvärde (Hb). Det låga blodvärdet beror på att nybildningen av röda blodkroppar är nedsatt. Många DBA patienter är kortväxta, en del har medDiamond-Blackfan anemia (DBA) is a congenital erythroid aplasia that usually presents as macrocytic anemia during infancy. Linkage analysis suggests that at least four genes are associated with DBA of which two have been identified so far. The known DBA genes encode the ribosomal proteins S19 and S24 accounting for 25% and 2% of the patients respectively. This study shows that RPS19 gene transfer

Dalhedes undersökning i två band koncentreras kring en protestantisk ”Augsburger-Kreis” med familjen Pemer, som i Sverige brukat kallas ”vallonsk”. Den moderna uppfattningen att de tyska invandrarna till Sverige alla varit nordtyskar, kritiseras med framgång. Religionen undersöks som ”förbindande element”, och protestanternas osäkra situation i Augsburg undersöks noga, med införandet av den nya ka

The thesis treats model reduction for linear time-varying systems. Time-varying models appear in many fields, including power systems, chemical engineering, aeronautics, and computational science. They can also be used for approximation of time-invariant nonlinear models. Model reduction is a topic that deals with simplification of complex models. This is important since it facilitates analysis an

The formation of beryllium in the early Galaxy is discussed. It is shown that if spallation occurs predominantly in regions rich in heavy elements, i.e., close to supernovae, the linear relation recently obtained by Gilmore et al. (1992) between beryllium and oxygen abundances for Population II stars may be reproduced. Estimates of relevant timescales for mixing show that the decisive factor, the

In linear multistep methods with variable step size, the method's coefficients are functions of the step size ratios. The coefficients therefore need to be recomputed on every step to retain the method's proper order of convergence. An alternative approach is to use step density control to make the method adaptive. If the step size sequence is smooth, the method can use constant coefficients witho

The lux-gene fused Ralstonia eutropha, when adapting to static conditions, causes stratification of air-exposed and nutrient-rich cultures at above 0.15 mg biomass ml(-1). The O-2 respiring biofilm (luminous neuston) phase, along with the dark sub-neustonic suspension phase, develops within 5-60 min. The instability of the biphasic static culture was identified as a reason for occasionally observa

In the present article a multi-YAG laser cluster and a framing camera have been applied for ultrahigh framing rate and three-dimensional measurements of formaldehyde distribution in flames and engines. The measurement technique utilizes a laser/detection system which has been adopted for the generation of eight laser pulses at 355 nm. By combining these lasers with a framing camera, short movies s

This study was based on laboratory incubations of mor humus from two N fertilized stands of Norway spruce in Sweden (Skogaby and Strasan), which had received repeated N additions (100 kg N ha(-1) yr(-1) as (NH4)(2)SO4 at Skogaby and 35, 73 and 108 kg ha(-1) yr(-1), as NH4NO3 at Strasan) during 8 and 24-29 years, respectively. The aim was to investigate long-term N effects on the mineralization of

In a series of 83 patients undergoing coronary artery bypass grafting for angina, perceived QOL (quality of life) was rated by the patients and their spouses, preoperatively and at two and 12 months postoperatively, using the SWED-QUAL instrument. One year after surgery, QOL had improved to a level which might be expected of a normal population comparable in age and gender distribution. Good corre

Mammographic screening may reduce breast cancer mortality. Not all women, however, come for examination. The objective in this study from Malmo has been to assess extent to which the rate of nonattendance varies between residential areas with different sociodemographic profiles. The study is based on 32,605 women, 45 to 68 years old and living in 17 areas, who between 1990 and 1994 were invited to

The authors analyze a male nurse's account of how he experienced his interaction with a female schizophrenic client during sessions of systematic clinical supervision. Notes taken during 15 sessions were analyzed by means of open coding. The analysis revealed the importance of being aware of the parallel process that occurs among the client, the primary nurse, and the unit staff.