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Heat production rate in polymorphonuclear granulocytes from patients with acute myelogenous leukaemia and healthy individuals
Heat production rate in polymorphonuclear granulocytes (PMN) from 18 AML patients and 21 healthy individuals was measured using microcalorimetry. An increased PMN heat production rate was found in most AML patients at diagnosis and during the first 6 months of remission. In 7/7 patients showing values above the normal mean level the heat production rate decreased during sequential analysis. The in
Complete remission in a patient with acute myelogenous leukemia treated with leukocyte α-interferon and cimetidine
A 76-year-old woman with acute myelogenous leukemia with approximately 65% myeloblasts on bone marrow examination was treated daily with a combination of 4 megaU of leukocyte interferon IM and 1,000 mg cimetidine PO. During therapy there was a gradual decrease of bone marrow myeloblasts down to 9% and a normalization of peripheral white blood cells. The treatment was discontinued after 6 weeks bec
Entrepreneurial Ecosystems in Life Science Industry : A study of start-ups, scale ups and resilience of Entrepreneurial Ecosystems
The Entrepreneurial Ecosystem (EE) literature has presented itself as promising in recent years, as it adopts a systemic network approach on entrepreneurship. Despite its popularity, scholars have also raised some serious concerns, showing it is yet a rather underdeveloped concept. This dissertation addresses some of critiques on the EE literature by proposing four research papers that consist of
Rec av Håkan Möller, Psalmernas värld : Tre studier i 1695 års psalmbok
Innehållsredovising och granskning
On the origin of geometrid moths: the phylogenetic relationships and taxonomy
Geometrid moths represent one of the largest radiations of Lepidoptera. Phylogenetic analyses based on morphological and molecular data supports the monophyly of this group of moths. However, the subfamilial and tribal compositions of major groups are still unresolved, leading to unstable classifications. In this thesis, I investigate the phylogenetic relationships of higher geometrid taxa with th
Development of a real-time quantitative PCR method for detection and quantification of Prevotella copri
Background: Since its discovery in 2007, the importance of the human gut bacterium Prevotella copri (P. copri) has been widely recognized with its links to diet and health status and potential as next generation probiotic. Therefore, precise, convenient and cost-effective diagnostic tools for the detection and quantification of P. copri from clinical and environmental samples are needed. Results:
Evaluation of a training program for life skills education and financial literacy to community health workers in India : a quasi-experimental study
Background: Accredited Social Health Activists (ASHA) are community health workers responsible for improving the health status of people by facilitating their access to healthcare services. The life skills of ASHA are known to be effective in negotiating behaviour change in the community; however, there has been a meagre focus towards improving them. Considering this gap, we adopted a comprehensiv
Probing tissue microstructure by diffusion skewness tensor imaging
Probing the cellular structure of in vivo biological tissue is a fundamental problem in biomedical imaging and medical science. This work introduces an approach for analyzing diffusion magnetic resonance imaging data acquired by the novel tensor-valued encoding technique for characterizing tissue microstructure. Our approach first uses a signal model to estimate the variance and skewness of the di
The spatial RNA integrity number assay for in situ evaluation of transcriptome quality
The RNA integrity number (RIN) is a frequently used quality metric to assess the completeness of rRNA, as a proxy for the corresponding mRNA in a tissue. Current methods operate at bulk resolution and provide a single average estimate for the whole sample. Spatial transcriptomics technologies have emerged and shown their value by placing gene expression into a tissue context, resulting in transcri
Comparison of short-pulse subthreshold (532 nm) and infrared micropulse (810 nm) macular laser for diabetic macular edema
The purpose of the study was to assess both anatomic and functional outcomes between short-pulse continuous wavelength and infrared micropulse lasers in the treatment of DME. This was a prospective interventional study from tertiary care eye hospital—King Khaled Eye Specialist Hospital (Riyadh, Saudi Arabia). Patients with center-involving diabetic macular edema were treated with subthreshold lase
Socio-economic disparities in the dispensation of antibiotics in Sweden 2016–2017: An intersectional analysis of individual heterogeneity and discriminatory accuracy
Aims: Antimicrobial resistance presents an increasingly serious threat to global public health, which is directly related to how antibiotic medication is used in society. Actions aimed towards the optimised use of antibiotics should be implemented on equal terms and according to the needs of the population. Previous research results on differences in antibiotic use between socio-economic and demog
Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability
Differences between sexes contribute to variation in the levels of fasting glucose and insulin. Epidemiological studies established a higher prevalence of impaired fasting glucose in men and impaired glucose tolerance in women, however, the genetic component underlying this phenomenon is not established. We assess sex-dimorphic (73,089/50,404 women and 67,506/47,806 men) and sex-combined (151,188/
Subacute phase of subarachnoid haemorrhage in female rats : Increased intracranial pressure, vascular changes and impaired sensorimotor function
Objective: Early brain injury (EBI) and delayed cerebral ischemia (DCI) after subarachnoid haemorrhage (SAH) has devastating consequences but therapeutic options and the underlying pathogenesis remain poorly understood despite extensive preclinical and clinical research. One of the drawbacks of most preclinical studies to date is that the mechanisms behind DCI after SAH are studied only in male an
Modeling of exhaust gas cleaning by acid pollutant conversion to aerosol particles
Sulfur and nitrogen oxides (SOx and NOx) are harmful pollutants emitted into the atmosphere by industry and transport sectors. In addition to being hazardous gases, SOx and NOx form sulfuric and nitric acids which contribute to the formation of airborne particulate matter through nucleation and condensation, hence magnifying the environmental impact of these species. In this work, we build a model
Condensation of iso-humulone in solution and at hydrophobic surfaces
Iso-humulone is an essential component for beer derived from hop, which is able to improve foam stability, increase bitterness and prolong shelf life, but its physiochemical properties have not been fully characterised. There is a limited amount of knowledge on how iso-humulone behaves in solution and at interfaces. In this work, the properties of iso-humulone are characterised in solution and at
Impact of discharge port configurations on the performance of sliding vane rotary compressors with a rotating cylinder
With the increasing requirements of compressed gas energy storage systems for compressors and expanders, sliding vane rotary compressors are worth trying. To study the influence of different configurations of discharge ports on the performance of compressors, numerical simulations are conducted on the innovative sliding vane compressors with a rotating cylinder. The reliable Renormalization Group
Translating the success of prophylaxis in haemophilia to von Willebrand disease
Introduction: There is limited awareness of von Willebrand disease (VWD), leading to challenges in both diagnosis and defining the optimal treatment approach for these patients. Patients with VWD are typically treated on-demand, with short-term prophylaxis used during surgery. In contrast, early initiation, and long-term use of prophylaxis is the standard of care in patients with severe haemophili
Utilization of greenhouse effect for the treatment of COVID-19 contaminated disposable waste - A simple technology for developing countries
Countries with abundant solar radiation have the potential to invest in simple technologies for deactivation of many bacteria and viruses in medical solid waste. In addition to the traditional Infection and Prevention Control (IPC) measures, these simple technologies contribute to better protection of health care workers in countries with compromised solid management schemes. Monitoring of tempera
A numerical stability analysis for the Einstein-Vlasov system
We investigate stability issues for steady states of the spherically symmetric Einstein-Vlasov system numerically in Schwarzschild, maximal areal, and Eddington-Finkelstein coordinates. Across all coordinate systems we confirm the conjecture that the first binding energy maximum along a one-parameter family of steady states signals the onset of instability. Beyond this maximum perturbed solutions