Background: p21-activated kinase 1 (Pak1) phosphorylates many proteins in both normal and transformed cells. Its ability to phosphorylate and thereby activate the estrogen receptor alpha (ER alpha) potentially limits the effectiveness of antiestrogen treatment in breast cancer. Here we studied associations between Pak1 expression and subcellular localization in tumor cells and tamoxifen resistance

-Glucosidases belong to families 1, 3 and 9 of the glycoside hydrolases and act on cello-oligosaccharides. Family 1 and 3 enzymes are retaining and are reported to have transglycosylation activity, which can be used to produce oligosaccharides and glycoconjugates. Family 3 enzymes are less well characterized than their family 1 homologues and to date only two crystal structures have been solved. H

The Einstein equations (EE) are certain conditions on the Riemann tensor on the real Minkowski space M. In the twistor picture, after complexification and compactification M becomes the Grassmannian Gr(2)(4) of 2-dimensional subspaces in the 4-dimensional complex one. Here we answer for which of the classical domains considered as manifolds with G-structure it is possible to impose conditions simi

Excited-state lifetimes for a number of vibronic states of (1)Pi(u) symmetry in molecular nitrogen have been determined experimentally in a laser-based pump-probe scheme using a coherent and tunable extreme ultraviolet source based on harmonic generation. States investigated in N-14(2) were b(1)Pi(u)(v = 6-9), of valence character, and c(3)(1)Pi(u)(v = 1) and o(3)(1)Pi(u)(v = 1), of Rydberg charac

Photon-echo-based devices have been proposed for many applications in data storage, image processing, and optical communications. Many of these applications would benefit if the output from the photon-echo process could be used as input in a second photon-echo process. We demonstrate the generation of such secondary echoes, using the amplified output from an initial photon-echo process. The amplif

Abstract This thesis consists of the following three papers Paper I. Hankel operators on Bergman spaces and similarity to contractions. In this paper we consider Foguel-Hankel operators on vector-valued Bergman spaces. Such operators defined on Hardy spaces play a central role in the famous example by Pisier of a polynomially bounded operator which is not similar to a contraction. On Bergman sp

De Geer moraine ridges occur in abundance in the coastal zone of northern Sweden, preferentially in areas with proglacial water depths in excess of 150 m at deglaciation. From detailed sedimentological and structural investigations in machine-dug trenches across De Geer ridges it is concluded that the moraines formed due to subglacial sediment advection to the ice margin during temporary halts in

One general class of attacks on stream ciphers is correlation attacks. Most of previous results regarding performance of correlation attacks have been based entirely on simulations. In this paper, we use random coding bounds for convolutional codes to give a theoretical analysis of a previously proposed correlation attack based on convolutional codes. The results from the theoretical derivation ar

Anaesthesia with closed anaesthetic systems demands knowledge of the physiology of the patients and of how the various anaesthetic gases behave in the organism as only the gases which the patients produces and absorbs are eliminated and replaced. The system is educational as it provides knowledge of the genuine absorption of oxygen and anaesthetic gases. The method is favourable to the environment