BACKGROUND: A large tumor volume negatively impacts the outcome of radiation therapy (RT). Altered fractionation (AF) can improve local control (LC) compared with conventional fractionation (CF). The aim of the present study was to investigate if response to AF differs with tumor volume in oropharyngeal cancer.METHODS: Three hundred and twenty four patients with oropharyngeal cancer treated in a r

Autoimmune (type 1) diabetes mellitus is a chronic disease without a cure. It affects primarily young people but may be diagnosed at any age. Strong genetic susceptibility characterizes the most common form of autoimmune diabetes in children younger than 18 years of age. Autoimmune diabetes is generally assumed to be hereditary, although the majority of patients do not have a family history of aut

Layered materials can usually grow without strain on top of distinct substrates if the only interaction between them is due to van der Waals forces. In such a scenario it would be expected that the heterointerface made up of weak bounds would not affect the overlayed material significantly for several large lattice-mismatched systems. Here we have studied the first stages of the heteroepitaxial gr

Bioinformatics methods are increasingly needed and used to analyze and interpret extensive datasets many of which are produced by diverse high-throughput technologies. Unfortunately, it is quite common that published articles do not contain sufficient information to allow the reader to fully comprehend and repeat computational and other studies. Guidelines were developed for reporting studies and

In recent years two Swedish companies, Telia and Lundin Petroleum, have had to work hard to legitimate their actions as a result of allegations of criminal activity. In this paper, the corporate framings employed to deal with allegations of crime will be analysed on the basis of Stanley Cohen's (2009) theoretical work on processes of denial and neutralization techniques. More specifically, the papIn recent years two Swedish companies, Telia and Lundin Petroleum, have had to work hard to legitimate their actions as a result of allegations of criminal activity. In this paper, the corporate framings employed to deal with allegations of crime will be analysed on the basis of Stanley Cohen's (2009) theoretical work on processes of denial and neutralization techniques. More specifically, the pap

The capacity to get rid of excess heat produced during hard work is a possible constraint on parental effort during reproduction [heat dissipation limit (HDL) theory]. We released hard-working blue tits (Cyanistes caeruleus) from this constraint by experimentally removing ventral plumage. We then assessed whether this changed their reproductive effort (feeding rate and nestling size) and levels ofThe capacity to get rid of excess heat produced during hard work is a possible constraint on parental effort during reproduction [heat dissipation limit (HDL) theory]. We released hard-working blue tits (Cyanistes caeruleus) from this constraint by experimentally removing ventral plumage. We then assessed whether this changed their reproductive effort (feeding rate and nestling size) and levels of

The streaming instability is a leading candidate mechanism to explain the formation of planetesimals. However, the role of this instability in the driving of turbulence in protoplanetary disks, given its fundamental nature as a linear hydrodynamical instability, has so far not been investigated in detail. We study the turbulence that is induced by the streaming instability as well as its interacti

Introduction: Western Europe today is a culturally diverse society and expected to become more so in the future. When patients from unfamiliar cultures become critically ill and require intensive care, this places considerable demands on the cultural and linguistic competencies of the intensive care staff. Existing research regarding the transcultural aspects of intensive care is scarce and, in Sw

With no ambition to provide a complete inventory, this article introducesthe reader to the ways in which Malcolm X and his legacy have been usedwithin US hip-hop music. The central argument is that US hip-hop artists,since the birth of hip-hop, have been participating in the processes ofreinventing Malcolm X and his legacy by not only casting him as a symbolof local African American resistance aga

Objectives: To investigate associations between sexual identity and low leisure-time physical activity (LTPA). Study design: Cross-sectional study. Methods: The 2012 public health survey was conducted with a postal questionnaire in southern Sweden with 28,029 respondents, aged 18–80 years. Analyses were conducted with logistic regressions. Results: The prevalence of low LTPA among men and women we

Objective: Acute administration of the main protein component of high-density lipoprotein, apolipoprotein A-I (ApoA-1), improves glucose uptake in skeletal muscle. The molecular mechanisms mediating this are not known, but in muscle cell cultures, ApoA-1 failed to increase glucose uptake when infected with a dominant-negative AMP-activated protein kinase (AMPK) virus. We therefore investigated whe

BACKGROUND: Continuity models of midwifery care are rare in Sweden, despite its well-known positive effects. The aim was to describe pregnancy and birth outcome in women participating in a continuity of care project in a rural area of Sweden.METHOD: A register-based study of 266 women recruited to the project and a control group of 125 women from the same catchment area. Midwives provided antenata

This paper focuses on the patient's perspective and the philosophical underpinnings that support what might be considered optimal for the future design of the intensive care unit (ICU) patient room. It also addresses the question of whether the aspects that support at-homeness are applicable to ICU patient rooms. The concept of “at-homeness” in ICUs is strongly related to privacy and control of sp

Cerebrospinal fluid analyses and neuroimaging can identify the underlying pathophysiology at the earliest stage of some neurodegenerative disorders, but do not have the scalability needed for population screening. Therefore, a blood-based marker for such pathophysiology would have greater utility in a primary care setting and in eligibility screening for clinical trials. Rapid advances in ultra-se

Fixed-target experiments using primary electron beams can be powerful discovery tools for light dark matter in the sub-GeV mass range. The Light Dark Matter eXperiment (LDMX) is designed to measure missing momentum in high-rate electron fixed-target reactions with beam energies of 4 GeV to 16 GeV. A prerequisite for achieving several important sensitivity milestones is the capability to efficientl

The sharing economy has become prominent in the policy, business and academic discourse as a way to achieve greater levels of resource efficiency in sustainability transitions. An example is carsharing, which is regarded as a potential lever for change in sustainable mobility transitions. In this article we, apply the "ecologies of business models" perspective to investigate how carsharing initiat

Policies aiming to spur quality competition among health care providers are ubiquitous, but their impact on quality is ex ante ambiguous, and credible empirical evidence is lacking in many contexts. This study contributes to the sparse literature on competition and primary care quality by examining recent competition enhancing reforms in Sweden. The reforms aimed to stimulate patient choice and en