A general discovery in protein science in the past few decades has been the finding that a number of unrelated proteins and peptides all have a marked propensity to form amyloid fibrils in vivo and in vitro. These structures have become known as the pathological hallmark of some of the most prevalent neurodegenerative diseases. More recently, the process of amyloid formation has been demystified t

During the first year of NASA's Mars 2020 mission, Perseverance rover has investigated the dark crater floor unit of Jezero crater and four samples of this unit have been collected. The focus of this paper is to assess the potential of these samples to calibrate the crater-based Martian chronology. We first review the previous estimation of crater-based model age of this unit. Then, we investigate

SAR images are important data for observing the earth in all weather conditions. But the speckle noise contaminated the SAR images, obstructs their application. Speckle noise is primarily due to the phase fluctuations of the electromagnetic return signals. In this paper, we investigate the effect of speckles on the change detection result. Two cost functions are used in our change detection algori

A detailed understanding of the dynamics of photoinduced processes occurring in the electronic excited state is essential in informing the rational design of photoactive transition-metal complexes. Here, the rate of intersystem crossing in a Cr(III)-centered spin-flip emitter is directly determined through the use of ultrafast broadband fluorescence upconversion spectroscopy (FLUPS). In this contr

Abstract: Intraspecific color variation is often associated with camouflage or protection, but melanin-based color variation is also linked to behavioral and physiological aspects including boldness. In the melanin-based plumage color polymorphic tawny owl (Strix aluco), the grey morph is known to be more cryptic than the brown morph. Using 19 captive tawny owls (11 grey and 8 brown), we tested if

In this paper, balancing electricity production using renewable energy such as wind power, PV cells, hydropower, and CHP (combined heat and power) with biomass is carried out in relation to electricity consumption in primarily one major region in Sweden, SE-3, which contains 75% of the country’s population. The time perspective is hours and days. Statistics with respect to power production and con

Circulating tumor cells (CTCs) may provide a liquid biopsy approach to disease monitoring in small cell lung cancer (SCLC), a particularly aggressive tumor subtype. Yet, the prognostic role of CTCs during and after treatment in relation to baseline remains ill-defined. Here, we assessed the value of longitudinal CTC analysis and the potential of low-molecular-weight heparin (LMWH) to reduce CTC ab

The appearance of very low emittance, high-power synchrotron sources has resulted in ever longer beamlines, often requiring a very weak curvature on the mirrors that transport the beam to the experiment, where the radius of curvature is on the order of kilometers. Manufacturing weakly curved, low figure error grazing incidence mirrors is difficult as the mirrors must be manufactured to an accuracy

Context.Gaia Data Release 3 (DR3) contains the first release of magnitudes estimated from the integration of Radial Velocity Spectrometer (RVS) spectra for a sample of about 32.2 million stars brighter than GRVS∼ 14 mag (or G ∼ 15 mag). Aims. In this paper, we describe the data used and the approach adopted to derive and validate the GRVS magnitudes published in DR3. We also provide estimates of t

Cardiovascular diseases (CVDs) remain a leading cause of death globally. According to the American Heart Association, approximately 19.1 million deaths were attributed to CVDs in 2020, in particular, ischemic heart disease and stroke. Several known risk factors for CVDs include smoking, alcohol consumption, lack of regular physical activity, and diabetes. The last decade has been characterized by

Introduction: Fracture reduction and fixation of distal femur fractures are technically demanding. Postoperative malalignment is still commonly reported after minimally invasive plate osteosynthesis (MIPO). We evaluated the postoperative alignment after MIPO using a traction table with a dedicated femoral support. Methods: The study included 32 patients aged 65 years or older with distal femur fra

In this paper, we study total and differential observables of electro- and photoproduction of light ρ , ω and ϕ mesons as functions of the center-of-mass energy of the γp collision and momentum transfer squared |t|. The corresponding vector mesons wave functions have been computed in the framework of relativistic AdS/QCD holographic approach. A satisfactory description of all available data on gro

Context. The second Gaia data release, DR2, contained radial velocities of stars with effective temperatures up to Teff = 6900 K. The third data release, Gaia DR3, extends this up to Teff = 14 500 K. Aims.We derive the radial velocities for hot stars (i.e., in the Teff = 6900-14 500K range) from data obtained with the Radial Velocity Spectrometer (RVS) on board Gaia. Methods. The radial velocities

Objective To explore timing in relation to all types of adverse events (AEs), severity and preventability for patients undergoing acute and elective hip arthroplasty. Design A multicentre cohort study using retrospective record review with Global Trigger Tool methodology in combination with data from several registers. Setting 24 hospitals in 4 major regions of Sweden. Participants Patients ≥18 ye

Proton magnetic resonance spectroscopy (1H-MRS) offers a growing variety of methods for querying potential diagnostic biomarkers of multiple sclerosis in living central nervous system tissue. For the past three decades, 1H-MRS has enabled the acquisition of a rich dataset suggestive of numerous metabolic alterations in lesions, normal-appearing white matter, gray matter, and spinal cord of individ

The aim of this paper is to contribute to the empirical question of the labour organisation and the gender division of labour in a semi-landless rural group, crofters (Swedish torpare), during the nineteenth century, and thereby also add to the larger question of the role of gender division of labour in the formation of a wagedependent class. The crofters’ households performed contract-defined cor

A stressor-related disorder wherein traumatic experience precipitates protracted disruptions to mood and cognition, post-traumatic stress disorder (PTSD) is associated with wide-ranging abnormalities across the body. While various methods have investigated these deviations, only proton magnetic resonance spectroscopy (1H MRS) enables noninvasive measurement of small-molecule metabolites in the liv

Multiple sclerosis (MS) is a heterogeneous autoimmune disease for which diagnosis continues to rely on subjective clinical judgment over a battery of tests. Proton magnetic resonance spectroscopy (1H MRS) enables the noninvasive in vivo detection of multiple small-molecule metabolites and is therefore in principle a promising means of gathering information sufficient for multiple sclerosis diagnos

The pathophysiology of progressive multiple sclerosis remains elusive, significantly limiting available disease-modifying therapies. Proton MRS (1 H-MRS) enables in vivo measurement of small molecules implicated in multiple sclerosis, but its application to key metabolites glutamate, γ-aminobutyric acid (GABA), and glutathione has been sparse. We employed, at 7 T, a previously validated 1 H-MRS pr