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Clinical evaluation of an advanced category antihaemophilic factor prepared using a plasma/albumin-free method: pharmacokinetics, efficacy, and safety in previously treated patients with haemophilia A

The efficacy and safety of an advanced category recombinant antihaemophilic factor produced by a plasma- and albumin-free method (rAHF-PFM) was studied in 111 previously treated subjects with haemophilia A. The study comprised a randomized, double-blinded, crossover pharmacokinetic comparison of rAHF-PFM and RECOMBINATE rAHF (R-FVIII); prophylaxis (three to four times per week with 25-40 IU kg(-1)

Power, Culture and Method in Comparative Law

This review essay draws on a recently edited handbook by Esin Orucu and David Nelken to reflect on the methodological concerns and challenges of comparative law and socio-legal research. It argues that the contextualisation of laws should be regarded as the indispensable methodological characteristic of all comparative studies of law that aspire to transcend the understanding of law as a body of r

Nuchal cord in post-term pregnancy - relationship to suspected intrapartum fetal distress indicating operative intervention.

Abstract Color Doppler Ultrasound was performed on 202 post-term pregnancies to detect the presence of a nuchal cord. A nuchal cord was diagnosed if the umbilical cord could be followed 360 degrees around the fetal neck. The results were not disclosed to the managing obstetrician, midwife, and patient. The perinatal outcome was analyzed according to Apgar score, umbilical cord artery and vein pH a

Monophyletic groups within the Parmeliaceae identified by ITS rDNA, beta-tubulin and GAPDH sequences

Phylogenetic relationships within the Parmeliaceae are analysed cladistically on the basis of DNA characters from partial beta-tubulin, partial glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and ITS sequences. 100 taxa representing 73 of the 88 genera currently recognised are included in the analyses. Eight monophyletic groups including two or more genera were identified in the tree calculated f

The Swedish rectal cancer registry

Background: An audit of all patients with rectal cancer in Sweden was launched in 1995. This is the first report from the Swedish Rectal Cancer Registry (SRCR). Methods: Between 1995 and 2003, 13 434 patients treated for adenocarcinoma of the rectum were registered with the SRCR; there were approximately 1500 new patients annually. Results: Approximately half had an anterior resection, a quarter a

Safety of the probiotic strain Lactobacillus plantarum DSM 9843 (strain 299v) in an endocarditis animal model

Objective: Lactobacilli are often considered to be beneficial or non-pathogenic to man, with small numbers of human infections being reported, including septicemia and infective endocarditis. To verify the safety of Lactobacillus plantarum DSM 9843 (=strain 299v) administration, we used a well-known endocarditis animal model. Design: Experimental study using Sprague-Dawley rats. Setting: Universit

Combined use of exhaled nitric oxide and airway hyperresponsiveness in characterizing asthma in a large population survey

The aim of the present study was to see whether measurements of airway hyperresponsiveness (AHR) and nitric oxide (NO) in exhaled air (ENO) either separately or in combination, could differentiate between asthmatics and healthy control subjects in a population based survey. In central Norway 8,571 adolescents participated in a large-scale epidemiological survey (Young Helseundersokelsen i Nord-Tro

Modeling drying and energy performance of industrial through-dryers

A model of an industrial through-dryer for production of tissue paper was developed. The model can be used to predict the performance of a dryer section of an industrial through-drying machine consisting of one or more through-drying rolls separated by free draw sections. Roll diameters, wrap angles, machine speed, basis weight, initial paper moisture ratio, operating pressure differentials, dryin

Interrogative Belief Revision in Modal Logic

The well known AGM framework for belief revision has recently been extended to include a model of the research agenda of the agent, i.e. a set of questions to which the agent wishes to find answers (Olsson & Westlund in Erkenntnis, 65, 165-183, 2006). The resulting model has later come to be called interrogative belief revision. While belief revision has been studied extensively from the point

Enriched environment after focal cortical ischemia enhances the generation of astroglia and NG2 positive polydendrocytes in adult rat neocortex

Environmental enrichment (EE) alleviates sensorimotor deficits after brain infarcts but the cellular correlates are not well-known. This study aimed to test the effects of postischemic EE on neocortical cell genesis. A neocortical infarct was caused by distal ligation of the middle cerebral artery in adult spontaneously hypertensive rats, subsequently housed in standard environment or EE. Bromodeo

Innovation management through the use of diversity networks

A methodology for innovation and analysis in a context of complex problem spaces is presented, introducing the idea of a diversity network. The methodology draws upon a framework which puts ‘complexification’ into systemic practice. Such an application helps individual participants to outline their narratives, create and agree upon categories, and use these to classify their narratives. Clusters o

Cidofovir for BK Virus-Associated Hemorrhagic Cystitis: A Retrospective Study

Background. BK virus-associated hemorrhagic cystitis (BKV-HC) is a severe complication after allogeneic hematopoietic stem cell transplantation (HSCT), but antiviral treatment for this condition has not been evaluated. Methods. We conducted a retrospective survey on the safety and outcome of cidofovir treatment for patients with BKV-HC in centers affiliated with the European Group for Blood and Ma

Cardiovascular and respiratory responses to apneas with and without face immersion in exercising humans.

The effect of the diving response on alveolar gas exchange was investigated in 15 subjects. During steady-state exercise (80 W) on a cycle ergometer, the subjects performed 40-s apneas in air and 40-s apneas with face immersion in cold (10°C) water. Heart rate decreased and blood pressure increased during apneas, and the responses were augmented by face immersion. Oxygen uptake from the lungs decr

Myocardial tissue damage in rabbits injected with group A streptococci, types M1 and M22. Role of bacterial immunoglobuhn G-binding surface proteins

Acute rheumatic fever (ARF) and acute poststreptococcal glomerulonephritis (APSGN), two important sequelae of streptococcal throat or skin infections, according to current concepts may be elicited by autoimmune mechanisms due to molecular mimicry between group A streptococci (GAS) and human tissue. In the case of APSGN, however, Our experimental data have indicated that GAS immunoglobulin-binding

Aquifer investigations in the Leon-Chinandega plains, Nicaragua, using electromagnetic and electrical methods

The Leon-Chinandega plains are located in the north-western part of Nicaragua and represent the most important groundwater reservoir of the country. The aquifer is comprised of three hydrogeological units. The top unit is an unconfined alluvial and below a more consolidated volcanic aquifer is found. These aquifers rest on an ignimbrite unit that acts as the basement of the aquifer. The plains are

Locally nilpotent 4-Engel groups are Fitting groups

Let G be a locally nilpotent 4-Engel group. We show that the normal closure of any element from G is nilpotent of class at most 4. When G has no element of order 2 or 5, the normal closure has class at most 3. These bounds are sharp. (C) 2003 Elsevier Inc. All rights reserved.

Cell cycle phase-dependent induction of ornithine decarboxylase-antizyme.

The activites of ornithine decarboxylase (ODC) and ODC inhibitory protein (ODC-antizyme) were studied in Ehrlich ascites tumor cells, separated according to their position in the cell cycle by centrifugal elutriation. Release and/or synthesis of ODC-antizyme was induced by putrescine treatment. Each mouse received an intraperitoneal injection of 25 moles of putrescine at 0, 1, 2, and 3 hr after tu

Design and dosimetry characteristics of a soft-docking system for intraoperative radiation therapy

PURPOSE: The design concept and the dosimetric characteristics of an applicator system for intraoperative radiation therapy (IORT) with special emphasis on alignment methods, the effect of a plastic scatterer in the beam, radiation leakage, and misalignment dosimetry, are presented in this paper. MATERIALS AND METHODS: A soft-docking system for a linear accelerator, which enables collimation of el