In an attempt to identify novel susceptibility genes predisposing to early-onset diabetes (EOD), we performed a genome-wide scan using 433 markers in 222 individuals (119 with diabetes) from 29 Scandinavian families with ≥2 members with onset of diabetes ≤45 years. The highest nonparametric linkage (NPL) score, 2.7 (P < 0.01), was observed on chromosome 1p (D1S473/D1S438). Six other regions on chr

Background: Development of multiple primary tumors is a hallmark of hereditary cancer. At least 1/10 of breast cancers and colorectal cancers occur because of heredity and recently the cell cycle kinase 2, CHEK2 1100delC allele has been identified at a particularly high frequency in families with hereditary breast and colorectal cancer. Methods: We utilized the Southern Sweden population-based can

OBJECTIVE—The goal of this study was to evaluate the performance of surrogate measures of insulin sensitivity and insulin secretion. RESEARCH DESIGN AND METHODS—The homeostasis model assessment (HOMA) of insulin resistance (IR) and the insulin sensitivity index (Si) from oral glucose tolerance test (OGTT) were compared with the M value from a hyperinsulinemic-euglycemic clamp in 467 subjects with

Reasons for performing study: One of the most common causes of lameness in racehorses is osteoarthritis (OA). Pathogenesis is not clear and pathological processes of the different joint tissues interact in often progressive events. The interface between cartilage and newly synthesised bone has been shown to be particularly enriched in bone sialoprotein (BSP), a cell-binding matrix protein. Objecti

Rapporten bygger på en undersökning där fyra dagstidningars bild av alkohol under tre tidsperioder ingår. resultatn visar att pressmaterialet inte uppvisar några större variationer vare sig mellan de stuerade tidningarna eller över tid. vidare visas att alkholfrågan beskrivs ur en rad olika perspektiv, dock sällan ur ett hälsoperspektiv.

Abstract is not available

Popular Abstract in Swedish Lokalbedövningsmedel ger en god smärtlindring efter centrala och perifera nervblockader. I många kliniska situationer hade det dock varit önskvärt med en längre duration av nervblockaden. De olika delarbetena i denna avhandling fokuserade på detta problem. Indianerna i Syd Amerika har länge känt till att om man tuggar bladen ifrån Erythroxylon Coca så upplev's en bedövLocal anaesthetics provide excellent pain relief after central and peripheral nerve blocks. However, in many clinical situations there is an insufficient duration of action to allow effective treatment of long-term pain with single injection techniques. This problem became the focus of the present studies. The natives in South America used to chew the leaves from Erythroxylon Coca and were well aw

AIM: The aim of this paper is to investigate structure, content and effects of systematic clinical supervision (SCS). BACKGROUND: Home care staff caring for people with dementia were offered SCS because the increasing number of elderly people with dementia increases the demands made on nurses. METHOD: Supervisors (n = 5) and SCS participants (n = 6) were interviewed and an additional 52 SCS partic

Intraportal tumour cell (TC) injection activates platelets which release serotonin (5-HT). Thrombocytopenia or 5-HT blockade decrease the hepatic lodgement of the injected TCs. A hypothetical explanation of this is 5-HT inhibition of TC killing by phagocytes (e.g. leukocytes and Kupffer cells). In this study, leukocyte phagocytosis was analysed by a chemiluminescence technique at different 5-HT co