Objective: The comparative efficacy and safety of prasugrel and ticagrelor in patients with myocardial infarction (MI) treated with percutaneous coronary intervention (PCI) remain unclear. We aimed to investigate the association of treatment with clinical outcomes. Methods: In the SWEDEHEART (Swedish Web-system for enhancement and development of evidence-based care in heart disease evaluated accor

In unicellular bacteria, the ParA and ParB proteins segregate chromosomes and coordinate this process with cell division and chromosome replication. During sporulation of mycelial Streptomyces, ParA and ParB uniformly distribute multiple chromosomes along the filamentous sporogenic hyphal compartment, which then differentiates into a chain of unigenomic spores. However, chromosome segregation must

Nitrogenase is the only enzyme that can cleave the triple bond in N2, making nitrogen available to plants (although the enzyme itself is strictly microbial). It has been studied extensively with both experimental and computational methods, but many details of the reaction mechanism are still unclear. X-ray crystallography is the main source of structural information for biomacromolecules, but it h

Aims: We investigated the risk of latent autoimmune diabetes in adults (LADA) and type 2 diabetes in relation to a healthy lifestyle, the proportion of patients attributable to an unhealthy lifestyle, and the influence of family history of diabetes (FHD) and genetic susceptibility. Methods: The population-based study included incident LADA (n = 571), type 2 diabetes (n = 1962), and matched control

Optical nonlinear spectroscopies carry a high amount of information about the systems under investigation; however, as they report polarization signals, the resulting spectra are often congested and difficult to interpret. To recover the landscape of energy states and physical processes such as energy and electron transfer, a clear interpretation of the nonlinear signals is prerequisite. Here, we

This article offers an analysis of three popular Swedish handbooks for new parents, written by authors in the “media class.” In these texts breastfeeding as a gendered, embodied practice collides with the Swedish ideal of gender-equal parenting. The analysis explores the various ways that gendered bodies, gendered (parental) rights, and gender equality figure in the handbooks, drawing upon feminis

Metal halide perovskites show great promise for a wide range of optoelectronic applications but are plagued by instability when exposed to air and light. This work presents low-temperature solution growth of vertically aligned CsPbBr3 nanowire arrays in AAO (anodized aluminum oxide) templates with excellent stability, with samples exposed to air for 4 months still exhibiting comparable photolumine

Summary: Frailty reflects an accelerated health decline. Frailty is a consequence of fracture and contributes to fracture. Greater frailty was associated with higher fracture risk. Frail women were at immediate risk (within 24 months) of a hip or major fracture. Fracture prevention could be improved by considering frailty status. Introduction: Frailty encompasses the functional decline in multiple

Purpose: In the last decade, the research community has focused on defining reliable biomarkers for the early detection of Alzheimer’s disease (AD) pathology. In 2017, the Geneva AD Biomarker Roadmap Initiative adapted a framework for the systematic validation of oncological biomarkers to cerebrospinal fluid (CSF) AD biomarkers—encompassing the 42 amino-acid isoform of amyloid-β (Aβ42), phosphoryl

Art forms tend to mirror themselves in each other. In order to understand literature and fine arts better, we often turn to music, speaking of the ‘tone’ in a book and of the ‘rhythm’ in a painting. In attempts to understand music better, we turn instead to the narrative arts, speaking of the ‘story’ of a musical piece. This book focuses on two examples of such conceptual mirror reflexivity: narraArt forms tend to mirror themselves in each other. In order to understand literature and fine arts better, we often turn to music, speaking of the ‘tone’ in a book and of the ‘rhythm’ in a painting. In attempts to understand music better, we turn instead to the narrative arts, speaking of the ‘story’ of a musical piece. This book focuses on two examples of such conceptual mirror reflexivity: narra

This paper represents a study of the geopolitical reasoning of the Georgian Orthodox Church (GOC) and its leader Patriarch Ilia II regarding the question of Georgia's territorial integrity. Does the GOC's territorial discourse complement or challenge Georgia's territorial nationalism? The empirical analysis of the geopolitical discourses of Patriarch Ilia II in the early 1990s and in the wake of t

INTRODUCTION: Formalized triage in the emergency department (ED) is not widely used in Denmark; this study explores the effects of introducing a five-level process triagesystem in a Danish ED.MATERIAL AND METHODS: Semi-structured qualitative interviews were conducted with 15 emergency nurses.The interviews were preceded by observations of thework of the ED nurses in which focus was on the triagepr

Objective To compare the Danish Emergency Process Triage (DEPT) with a quick clinical assessment (Eyeball triage) as predictors of short-term mortality in patients in the emergency department (ED).Methods The investigation was designed as a prospective cohort study conducted at North Zealand University Hospital. All patient visits to the ED from September 2013 to December 2013 except minor injurie