Investigating the Mechanism of Action of DNA Damage Response Inhibitors Cancer is a complex, heterogenous, systemic disease. It is considered to be a leading cause of death worldwide. Currently, there is limited treatment for this disease and the field of oncology presents the highest percentage of failed trials (32%) for drugs in phase II and phase III, mainly due to lack of efficacy or safety.

Objective: To investigate fatigue at baseline and 3.5 years later and its association with balance and gait over time.Background: In Parkinson’s disease (PD), fatigue is considered one of the most common and disabling nonmotor symptoms that may persist or even worsen over time. Fatigue in generally has been described as a significantly diminished energy level or an increased perception of effort d

The risk of breast cancer associated with CHEK2:c.1100delC is 2-threefold but higher in carriers with a family history of breast cancer than without, suggesting that other genetic loci in combination with CHEK2:c.1100delC confer an increased risk in a polygenic model. Part of the excess familial risk has been associated with common low-penetrance variants. This study aimed to identify genetic loci

OBJECTIVE: To study the effect of methotrexate on male fertility and subsequent effects on their children, for which data are scarce and contradictory.DESIGN: Nationwide multiregister cohort study.SETTING: Not applicable.SUBJECT(S): All children born alive in Sweden between 2006 and 2014 and their fathers. Three cohorts were defined: children to fathers with periconceptional methotrexate exposure

The building sector is the biggest energy user in the European Union (EU) and therefore, has an important role to play in meeting the energy and climate goals ofEU. In Sweden, more than 80% of the two million detached houses are more than 35 years of age. Energy efficiency renovation of those old houses can reduce primary energy use by 65% to 90%. However, the current low rate of energy renovation

BackgroundUniversity students experience a distinct working environment in the context of completing their studies. In line with existing research into the connection between workplace environment and stress, it is rational to believe that such study environments can affect the level of stress that students experience. However, few instruments have been developed for measuring this.ObjectiveThe ai

Deep renovation of the buildings is a key for sustainable development, however, the rate of deep renovation of residential buildings in the European Union (EU) is lower than what is required to meet the climate and energy goals. This paper analyses peculiarities and commonalities in market conditions and approaches to deep renovation of single-family (or detached) houses in Denmark and Sweden. The

In this paper, we identify the socio-economic attributes and attitudes that have influenced house owners in renovating their homes in the past. Our study is based on responses to an online questionnaire survey of 971 house owners living in Kronoberg County in Sweden. Results showed that the interest and willingness of the house owners to perform a renovation varied depending on their demographic b

This paper compares the quality of private and public health care, by studying Swedish care homes for elderly and disabled persons. The outcome of interest is the prevalence of pressure ulcers. Pressure ulcers are partly preventable by for example care home staff routines, nutrition and movement plans. As pressure sores is one of the most common healthcare injuries, comparisons of pressure sore pr

The primary aim of this study has been to examine to what extent people with addiction experience feelings of loss and sorrow as they go from being active in their abuse, to being an addict in recovery. The study is based on life stories generated from semi-structured, qualitative interviews, meaning the results are built on the voices of 6 people who are all recovering addicts. The complex emotio

The present review summarizes data collected by the Swedish National Cataract Register (NCR), which by the end of 2021 contained data for more than 2.4 million cataract surgeries between 1992 and 2021. During these 30 years, the cataract surgery rate rose from 3700 to 12 800. The coverage of NCR is very high including 93% of all cataract procedures in Sweden between 2010 and 2021. Independently of

Recent progress in chemical vapour deposition (CVD) technology has enabled synthesis of metastable cubic Ti1−xAlxN coatings with x as high as 0.8–0.9. These coatings have unique micro- and nano-structures consisting of grains with epitaxially grown nanolamellae with different Al/Ti ratios, and exhibit exceptional hardness and resistance to wear and oxidation. Here, the thermal stability and decomp

This bachelor thesis studies the probabilities of dice rolls in tabletop roleplaying games, to see if any correlation can be found between the system and the desired theme for the game. Due to the growing popularity of tabletop roleplaying, it is a field worth exploring, as it touches the lives of many people around the world. Four different roleplaying systems is studied, and through comparing pr

Kan arkitekter använda det skrivna ordet till att förändra världen?MANI-FEST bjuder in ett antal unga svenska arkitektkontor till att formulera sig i korta och slagkraftiga meningar. Har manifestet någon betydelse för dagens och framtidens arkitekter? Vilka frågor engagerar en ung svensk arkitekt just nu? Detta är en reflektion över ordets makt, manifestets möjligheter och vad som är viktigt för d

Although classic voting studies noted that voters may reach their voting decision on the basis of different criteria most contemporary voting studies assume that one voting model fits all. Building on the limited, but developing literature on the topic, this paper develops and tests models incorporating voter decision criteria heterogeneity. Paying particular attention to the role of voter sophist