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Prolonged and intense neuroinflammation after severe traumatic brain injury assessed by cerebral microdialysis with 300 kDa membranes

Background: A neuroinflammatory response that may lead to edema and secondary brain damage is elicited in severe traumatic brain injury (TBI). Previous studies using microdialysis (MD) membranes with 100 k Dalton (kDa) cut-off found a transient intracerebral release of cytokines and chemokines without significant correlations to clinical course, intracranial pressure (ICP) or metabolites. In this

Comparison of membrane fouling during ultrafiltration with adsorption studied by quartz crystal microbalance with dissipation monitoring (QCM-D)

Even though membrane technology is used in numerous industrial applications, membrane fouling is still a major challenge. Valuable information on the formation kinetics and structure of the fouling layer can be obtained by in situ real-time monitoring. Quartz crystal microbalance with dissipation monitoring (QCM-D) enables the study of adsorptive fouling in situ on a model membrane. However, so fa

Synchrotron-based near ambient-pressure X-ray photoelectron spectroscopy and electrochemical studies of passivation behavior of N- and V-containing martensitic stainless steel

Passivation behavior of a N- and V-containing martensite stainless steel was studied by synchrotron-based near ambient-pressure X-ray photoelectron spectroscopy, electrochemical analyses, and thermodynamic calculation. The passive film consists of Cr3+, Fe(2, 3)+, and V(2, 3, 4)+ oxides as inner layer, and Cr3+ and Fe3+ hydroxides as outer layer. Austenitization at 1080 oC (rather than 1010 oC) an

Role of Mannose-binding Lectin and Association with Microbial Sensitization in a Cohort of Patients with Atopic Dermatitis

Atopic dermatitis is a relapsing inflammatory skin condition, in which bacteria, fungi and viruses may colonize the skin and aggravate the condition. Mannose-binding lectin is part of the innate immune system. Polymorphism in the mannose-binding lectin gene can result in deficiency of mannose-binding lectin, which may affect defence against microbes. The aim of this study was to investigate whethe

Establishing meaning recall and meaning recognition vocabulary knowledge as distinct psychometric constructs in relation to reading proficiency

The purpose of this paper is to (a) establish whether meaning recall and meaning recognition item formats test psychometrically distinct constructs of vocabulary knowledge which measure separate skills, and, if so, (b) determine whether each construct possesses unique properties predictive of L2 reading proficiency. Factor analyses and hierarchical regression were conducted on results derived from

Long-term effect of stepped-care vs in-person cognitive behavioral therapy for pediatric obsessive-compulsive disorder

Long-term follow-up data from trials of digital mental health interventions are rare. This study reports 2-year follow-up data from a non-inferiority trial (N = 152) comparing stepped-care (internet-delivered cognitive behavioral therapy [CBT] followed by traditional in-person CBT if needed) vs in-person CBT for pediatric obsessive-compulsive disorder. Both treatment groups had comparable long-ter

Using machine learning to select variables in data envelopment analysis : Simulations and application using electricity distribution data

Agencies that regulate electricity providers often apply nonparametric data envelopment analysis (DEA) to assess the relative efficiency of each firm. The reliability and validity of DEA are contingent upon selecting relevant input variables. In the era of big (wide) data, the assumptions of traditional variable selection techniques are often violated due to challenges related to high-dimensional

Size-resolved characterization of particles >10 nm emitted to air during metal recycling

Background: In the strive towards a circular economy, metal waste recycling is a growing industry. During the recycling process, particulate matter containing toxic and allergenic metals will be emitted to the air causing unintentional exposure to humans and environment. Objective: In this study detailed characterization of particle emissions and workplace exposures were performed, covering the fu

Real-world long-term effects on blood pressure and other cardiovascular risk factors for patients in digital therapeutics

Purpose Hypertension is a leading causeof premature death worldwide and a major public health problem. This study investigated the long-term effects (>1 year) of digital hypertension monitoring by home blood pressure (HBP) measurements in combination with individualized remote treatment via a Swedish Digital Therapeutics platform in a large patient population. Methods The primary endpoint, HBP, an

P90 ribosomal S6 kinases : A bona fide target for novel targeted anticancer therapies?

The 90 kDa ribosomal S6 kinase (RSK) family of proteins is a group of highly conserved Ser/Thr kinases. They are downstream effectors of the Ras/ERK/MAPK signaling cascade. ERK1/2 activation directly results in the phosphorylation of RSKs, which further, through interaction with a variety of different downstream substrates, activate various signaling events. In this context, they have been shown t

Ancient Equality Against Modern Democracy : Resources of Critique in Hannah Arendt and Ellen Meiksins Wood

Increasing discontent with the current status of democracy has prompted a renewed interest in Athenian democracy. This article contributes with the first comparative analysis of two political theoreticians – Hannah Arendt and Ellen Meiksins Wood – whose reactivations of ancient political experiences significantly predate recent trends. Despite the fact that Arendt levelled fierce critique against

Perinatal risk factors for developmental coordination disorder in children born extremely preterm

Aim: Children born extremely preterm frequently have developmental coordination disorder (DCD). We aimed to evaluate perinatal risk factors for DCD. Methods: Swedish national cohort study including 226 children born before 27 gestational weeks without major neurodevelopmental disabilities at 6.5 years. Outcome was DCD, defined as ≤5th percentile on the Movement Assessment Battery for Children-Seco

Resistance, Materiality and the Spectre of Cartesianism : A Contribution to the Critique of Feminist New Materialism

An important camp within the emerging field of resistance studies has been characterised by a tendency to study and theorise matters of culture, language, and discourse at the expense of matter itself. For researchers interested in feminist resistance, feminist new materialism – with its focus on the entanglements of ‘natureculture’, matter, the body, sexual differ- ence, agency, and change – mighAn important camp within the emerging field of resistance studies hasbeen characterised by a tendency to study and theorise matters of culture,language, and discourse at the expense of matter itself. For researchersinterested in feminist resistance, feminist new materialism – with its focuson the entanglements of ‘natureculture’, matter, the body, sexual differ-ence, agency, and change – might app

Allergen immunotherapy for allergic asthma : The future seems bright

Allergen specific immunotherapy (AIT) is the only causal therapeutic option for allergic airway diseases including asthma and allergic rhinitis. AIT has been shown to restore the allergen immune tolerance, can modify both the early and late-onset allergen-specific airway hyperreactivity, helps to achieve disease control/remission and prevents new sensitisations. Recent real life data on long-term

Interpreting the Haitian Revolution : From the Rights of Man to Human Rights

In recent decades, a ‘Haitian Turn’ has emerged as both academic and public readerships in the anglophone sphere have been flooded by a wave of essays, articles, and monographs on the Haitian Revolution (1791–1804). At the epicentre of the present study is one of the major interpretations of the Haitian Revolution in the Haitian Turn, which I call the ‘universality paradigm’. The universality paraIn recent decades, a ‘Haitian Turn’ has emerged as both academic and public readerships in the anglophone sphere have been flooded by a wave of essays, articles, and monographs on the Haitian Revolution (1791–1804). At the epicentre of the present study is one of the major interpretations of the Haitian Revolution in the Haitian Turn, which I call the ‘universality paradigm’. The universality para

Striving towards normality in an unpredictable situation. A qualitative interview study of how persons newly diagnosed with incurable oesophageal and gastric cancer manage everyday life

Purpose: Getting an incurable oesophageal or gastric cancer diagnosis is a major stressful life event associated with severe physical, psychosocial and existential challenges. To provide timely and efficient support, based on patients' experiences, the aim of the study was to explore how patients newly diagnosed with incurable oesophageal and gastric cancer manage everyday life. Method: Semi-struc

Unreported incidental pulmonary embolism in patients with cancer : Radiologic natural history and risk of recurrent venous thromboembolism and death

Purpose: To assess the risk of recurrent venous thromboembolism (VTE) and death in patients with unreported cancer-associated incidental pulmonary embolism (iPE). Materials and methods: Matched cohort study on cancer patients with a CT study including the chest between 2014-01-01 and 2019-06-30. Studies were reviewed for unreported iPE, and cases were matched with controls without iPE. Cases and c