Calcium channels must be subjected to a very precise regulation in order to preserve cell function and viability. Voltage gated calcium channels (VGCC) represent the main pathway for calcium entry in excitable cells. This explains why depolarization induces a rapid-onset and short-term inactivation of calcium currents. Contrarily to this well-documented mechanism to maintain calcium below toxic le

Reconstruction with a Deep Inferior Epigastric Perforator (DIEP) flap is considered to be the first choice forautologous breast reconstruction. Skin and fat are transplanted from the lower abdomen to the chest were theblood vessels are reconnected through microsurgery. A total of 309 patients with unilateral DIEP flap and 23patients with expander prosthesis (EP) reconstructions were included in th

It has been known that load unaware channel selection in 802.11 networks results in high level interference, and can significantly reduce the network throughput. In current implementation, the only way to determine the traffic load on a channel is to measure that channel for a certain duration of time. Therefore, in order to find the best channel with the minimum load all channels have to be measu

We present a non-contact platelet functional analysis platform based on acoustic trapping of platelet clusters and activation monitoring using impedance spectroscopy. The system was characterized using polystyrene particles and human platelets. The system was also capable of transferring platelets from plasma into a controlled buffer. Trapped platelets were activated using 20 and 40 μM TRAP and th

Studies of nanoconfined circular DNA are of interest both from a biological as well as a fundamental polymer physics perspective. We here present the use of nanofluidic channels as a tool for comparing statics and dynamics of the linear and circular configuration of the same DNA molecule.

The theme of innovation (understood as the introduction of new products, processes, or organizational forms in the marketplace) is interdisciplinary in nature. Economic geographers started participating in the field early, but scholars from fields such as economics and innovation studies have also contributed to understanding the geography of innovation. Core topics have been to examine how innova

BACKGROUND: Chronic leg ulcers remain a challenge to the treating physician. Such wounds often need skin grafts to heal. This necessitates a readily available, fast, simple, and standardized procedure for grafting.OBJECTIVES: The aim of this work was to test a novel method developed for outpatient transplant procedures.METHODS: The procedure employs a handheld disposable dermatome and a roller min

Objectives To describe the development, implementation and lessons learned of lifestyle intervention to promote appropriate gestational weight gain among Hispanic pregnant women. Design The intervention was informed by an empowerment oriented theoretical framework, and targeted women in the Pregnancy and Early Life Improvement Study. Methods The nutrition component consisted of recommendations for

Debattartikel om utredningsdirektiv för lagstiftning om hemlig dataavläsning. Artikeln diskuterar den principiellt viktiga frågan om hur långt man kan gå för att skydda ett öppet och fritt demokratisk samhälle med polisiära övervakningsbefogenheter innan det där fria och öppna börja tummas på av själva befogenheterna, och tar utöver den avvägningsproblematiken upp risken med att upprätthålla säker

Rivers transport similar to 6 x 10(12) mol yr(-1) of dissolved Si (DSi) from the continents to the oceans. They also carry amorphous silica (ASi), solid phases likely to dissolve in seawater. Unfortunately, the magnitude of this flux is poorly constrained at a global scale. We present 92 new ASi values from suspended particulate matter (SPM) from the Ganges basin. Bulk SPM is 1.2% ASi, and mean AS

Background: Recent evidence shows that arthroscopic partial meniscectomy (APM) offers no benefit over conservative treatment of patients with a degenerative meniscus tear. However, patients who report mechanical symptoms (sensations of knee catching or locking) may benefit from APM. Objective: To assess whether APM improves mechanical symptoms better than sham surgery. Design: Randomized, patient-

This paper discusses the ecological optimisation of municipal waste management systems. The purpose of this paper is to help local decision-makers in designing integrated waste management solutions that are ecologically optimal. The study uses life-cycle assessment (LCA) methodology to build a model and test different waste management scenarios in order to see whether the waste management hierarch

IF steel sheets were processed by conventional symmetric and asymmetric rolling (ASR) at ambient temperature. The asymmetry was introduced in a geometric way using differential roll diameters with a number of different ratios. The material strength was measured by tensile testing and the microstructure was analyzed by optical and transmission electron microscopy as well as electron backscatter dif

Among the known severe plastic deformation (SPD) techniques, one particular group can be defined as SPD processing of thin samples. Their distinctive feature is that one of the sample dimensions, namely the thickness, is much smaller than the other two dimensions. Examples include High Pressure Torsion and two recently developed techniques: the Cone-Cone Method and the High Pressure Tube Twisting.