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SADB phosphorylation of gamma-tubulin regulates centrosome duplication.
Symmetrical cell division requires duplication of DNA and protein content to generate two daughter cells. Centrosomes also duplicate during cell division, but the mechanism controlling this process is incompletely understood. We describe an alternative splice form of SadB encoding a short SADB Ser/Thr kinase whose activity fluctuates during the cell cycle, localizes to centrosomes, and controls ce
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Psycho och den inre fienden
Kulturartikel om Alfred Histchcocks Psycho och filmens betydelse för att förändra skräckfilmsgenren.
Staphylococcus aureus and Squamous Cell Carcinoma of the Skin.
Squamous cell carcinoma (SCC) of the skin is a tumor with greatly increased incidence among immunosuppressed patients; therefore, an infectious cause of SCC has long been sought. We performed a hospital-based case-control study of Staphylococcus aureus and biopsies of SCC (n = 82), basal cell carcinoma (n = 142), actinic keratosis (n = 57), and seborrhoeic keratosis (n = 72) in comparison with bio
Long-term suicide risk of depression in the Lundby cohort 1947-1997 - severity and gender.
Objective: The long-term suicide risk of depression was evaluated in a community sample by severity and gender. Method: The Lundby study is a prospective, longitudinal cohort study on a population consisting of 3563 subjects. In 1947-1997 medium or severe depression according to the Lundby diagnostic system were registered in 503 subjects. The same subjects were also diagnosed according to DSM-IV
Nordic WAIS/World Wide Web Project. Project Description and Plan. Report of Phase I.
Determination of Absorption-line Parameters Using 2-tone Frequency-modulation Spectroscopy With Diode-lasers
Accurate determination of line parameters from weak absorption using two-tone frequency-modulation spectroscopy (TTFMS) with a GaAlAs diode laser is demonstrated. The air-broadening of three oxygen A-band lines is determined, using a least-squares fit. For a peak absorption of 1.3 x 10(-3) the deviation between the experimental and the fitted spectrum is less than 1%. The fitting procedure is succ
Genetic factors influencing the risk of multiple myeloma bone disease.
A major complication of multiple myeloma (MM) is the development of osteolytic lesions, fractures and bone pain. To identify genetic variants influencing the development of MM bone disease (MBD), we analyzed MM patients of European ancestry (totalling 3774) which had been radiologically surveyed for MBD. Each patient had been genotyped for ~600 000 SNPs with genotypes for six million common varian
Gunga med Galileo - matematik för hela kroppen
På en lekplats eller i en nöjespark finns möjlighet att påtagligt uppleva begrepp från fysik och matematik med den egna kroppen. Med hjälp av tidsmätningar kan man få förståelse för gungans pendelrörelse och även en matematisk modell. Innehållet presenterades på matematikbiennalen i Umeå.
The effects of high frequency subthalamic stimulation on balance performance and fear of falling in patients with Parkinson's disease.
BACKGROUND: Balance impairment is one of the most distressing symptoms in Parkinson's disease (PD) even with pharmacological treatment (levodopa). A complementary treatment is high frequency stimulation in the subthalamic nucleus (STN). Whether STN stimulation improves postural control is under debate. The aim of this study was to explore the effects of STN stimulation alone on balance performance
Analysis of fracture by means of the fictitious crack model, particularly for fibre reinforced concrete
Increased Sensitivity to Broadly Neutralizing Antibodies of End-Stage Disease R5 HIV-1 Correlates with Evolution in Env Glycosylation and Charge.
Induction of broadly neutralizing antibodies, such as the monoclonal antibodies IgGb12, 2F5 and 2G12, is the objective of most antibody-based HIV-1 vaccine undertakings. However, despite the relative conserved nature of epitopes targeted by these antibodies, mechanisms underlying the sensitivity of circulating HIV-1 variants to broadly neutralizing antibodies are not fully understood. Here we have
Universiteter i deres samtid
Primary and secondary glomerulonephritides 1.
Increased litter size and super-ovulation rate in congenic C57BL mice carrying a polymorphic fragment of NFR/N origin at the Fecq4 locus of chromosome 9.
By analysing N2 mice from a cross between the inbred C57BL strain B10.Q and the NMRI-related NFR/N strain, we recently identified a quantitative trait locus (QTL) influencing litter size. This locus is now denoted Fecq4, and it is present on the murine chromosome 9. In the present paper, we describe how the Fecq4 fragment originating form the NFR/N mouse strain will affect B10.Q mice by means of b
Review of Roms kungatid
Review of Leif Carlsson, Round Trips to Heaven: Otherworldly Travelers in Early Judaism and Christianity
The human CXC chemokine granulocyte chemotactic protein 2 (GCP-2)/CXCL6 possesses membrane-disrupting properties and is antibacterial
Granulocyte chemotactic protein 2 (GCP-2)/CXCL6 is a CXC chemokine expressed by macrophages and epithelial and mesenchymal cells during inflammation. Through binding and activation of its receptors (CXCR1 and CXCR2), it exerts neutrophil-activating and angiogenic activities. Here we show that GCP-2/CXCL6 itself is antibacterial. Antibacterial activity against gram-positive and gram-negative pathog